Abstract
Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, and is defined by progressive stenosis or occlusion within the arteries of the lower extremities. Although PAD is the currently accepted international term for this clinical syndrome (1), historically, other names have been used interchangeably, including peripheral arterial occlusive disease (PAOD), arteriosclerosis obliterans (ASO), lower extremity occlusive disease (LEAD), and peripheral vascular disease (PVD). Widely prevalent, it has been estimated that more than 8.4 million people are afflicted with this disease in the United States (2,3). As with other clinical atherosclerotic syndromes, the etiology of PAD is due to both modifiable (diabetes, smoking, hypertension, and hypercholesterolemia) and nonmodifiable (e.g., age, gender, family history) risk factors.
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Bordeaux, L.M., Reich, L.M., Hirsch, A.T. (2003). The Epidemiology and Natural History of Peripheral Arterial Disease. In: Coffman, J.D., Eberhardt, R.T. (eds) Peripheral Arterial Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-331-6_2
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DOI: https://doi.org/10.1007/978-1-59259-331-6_2
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