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Population-Based Approaches to Alzheimer’s Disease Prevention

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Biomarkers for Alzheimer’s Disease Drug Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1750))

Abstract

Progress in prevention and treatment of Alzheimer’s disease (AD) and dementia is hampered by the restricted understanding of the biological and environmental causes underlying pathophysiology. It is widely accepted that certain genetic factors are associated with AD and a number of lifestyle and other environmental characteristics have also been linked to dementia risk. However, interactions between genes and the environment are not yet well understood, and coordinated global action is required to utilize existing cohorts and other resources effectively and efficiently to identify new avenues for dementia prevention. This chapter provides a brief summary of current research on risk and protective factors and opportunities and challenges in relation to population-based approaches are discussed.

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Acknowledgments

The author would like to thank the following individuals for their valuable contribution to the chapter: Profs Lefkos Middleton (Imperial College London, UK); Miia Kivipelto and Laura Fratiglioni (Karolinska Institutet Stockholm, Sweden); M. Arfan Ikram (Erasmus University Medical Center Rotterdam, The Netherlands); and Pascale Barberger-Gateau and Cécilia Samieri (Inserm U1219 and Bordeaux University, France).

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

    Robert Perneczky

  2. German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

    Robert Perneczky

  3. Neuroepidemiology and Ageing Research Unit, School of Public Health, The Imperial College of Science, Technology and Medicine, London, UK

    Robert Perneczky

  4. West London Mental Health NHS Trust, London, UK

    Robert Perneczky

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  1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

    Robert Perneczky

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Perneczky, R. (2018). Population-Based Approaches to Alzheimer’s Disease Prevention. In: Perneczky, R. (eds) Biomarkers for Alzheimer’s Disease Drug Development. Methods in Molecular Biology, vol 1750. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7704-8_2

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