Abstract
Progress in development and maturation of the brain has been shown to be paralleled by changes of gangliosides (Rösner, 1982). One generalization of these studies was that predominance of GD3 may characterize mitotically active precursor cells (Dreyfus et al., 1975; Rösner, 1980; 1982; Rösner et al., 1985; Goldmann et al., 1984) and accretion of more complex gangliosides indicates the transition to postmitotic young neurons (Rösner, 1980; 1982). In the present study, performed with chicken and rat embryos, immunohistochemical data obtained with monoclonal antibodies to gangliosides support the above conclusion.
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Abbreviations
- TLC:
-
thin chromatography
- PB:
-
sodium phosphate buffer
- IgG-B:
-
biotirylated antimousa IgG
- IgG-F:
-
fluoresciein-labeled antimouse IgG
- A-F:
-
fluoresciein-labeled avidin
- PGAA:
-
polysialoganglioside-associated antigen
- DRG:
-
dorsal root ganglion
- VR:
-
ventral root
- GH:
-
hexasialoganglioside.
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© 1986 Springer-Verlag Berlin Heidelberg
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Rösner, H., Willibald, C.J., Henke-Fahle, S. (1986). Expression of Ganglioside-Antigens During Neuronal Differentiation Studied by Use of Monoclonal Antibodies. In: Tettamanti, G., Ledeen, R.W., Sandhoff, K., Nagai, Y., Toffano, G. (eds) Gangliosides and Neuronal Plasticity. FIDIA Research Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5309-7_7
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DOI: https://doi.org/10.1007/978-1-4757-5309-7_7
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