Abstract
N-Acetyl-p-benzoquinone imine (NAPQI) is the putativereactive metabolite implicated in acetaminophenhepatotoxicity (Crocoran et al., Dahlin et al., Albano et al., and Rundgren et al.) which is a highly reactive electrophile as well as an oxidant (Rundgren et al.). Toxicity in isolated hepatocytes has been attibuted to the alkylation and/or oxidation of protein thiol groups (Albano et al. and Rundgren et al.).
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Abbreviations
- DEDC:
-
diethyldithiocarbamate
- DS:
-
disulfiram
- DTT:
-
dithiothreitol
- NAPQI:
-
N-Acetyl-p-Benzoquinone Imine
- GSH:
-
reduced glutathione
- GSSG:
-
oxidised glutathione
- Hepes:
-
4-(2-hydroxyethyl)-1-piperazine-ethane-sulphonic acid
- HPLC:
-
high performance liquid chromatography
- FAB:
-
fast atom bombardment
Reference
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© 1991 Plenum Press, New York
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Lauriault, V.V., O’Brien, P.J. (1991). The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_38
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_38
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