Abstract
Glutathione S-transferases catalyze the nucleophilic addition of glutathione to electrophilic substrates. Glutathione S-conjugate formation, followed by conversion to mercapturates, serves to detoxify potentially harmful xenobiotics. Alternatively, glutathione S-conjugate formation is an important bioactivation mechanism for several classes of compounds (Anders et al., 1988). The nephrotoxicity of several haloalkenes, including chlorotrifluoroethene (CTFE), is attributable to glutathione S- conjugate formation, metabolism of the glutathione S-conjugate to the corresponding cysteine S-conjugate, translocation to the kidney, and bioactivation by cysteine conjugate β-lyase (Figure 1).
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© 1991 Plenum Press, New York
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Hargus, S.J., Fitzsimmons, M.E., Anders, M.W. (1991). Stereochemistry of the Microsomal Glutathione S-Transferase-Catalyzed Addition of Glutathione to Chlorotrifluoroethene in Isolated Rat Hepatocytes. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_34
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_34
Publisher Name: Springer, Boston, MA
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