Abstract
Nitrosamines are well known carcinogenic compounds that require a metabolic activation to generate electrophilic species able to elicit toxic, mutagenic or carcinogenic damage in cells. This activation process, generally involving an α-Chydroxylation has been shown to be a cytochrome P-450 dependent reaction.
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© 1991 Plenum Press, New York
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Gervasi, P.G., Puccini, P., Longo, V., Lippi, A. (1991). Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine in Hamster. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_33
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_33
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