Abstract
Organothiocyanates and organonitriles are effective insecticide and fungicide chemicals. Glutathione-S-transferases may play a role in the liberation of HCN from organothiocyanates whereas mixed-function oxidases may play a role in HCN liberation from various organonitriles [Ohkawa et al., 1972].
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References
Butler, A.R. and Glidewell, C. (1987). Recent chemical studies of sodium nitroprusside relevent to its hypotensive action. Chem. Soc. Rev. 16, 361–380.
Devlin, D.J., Smith, R.P., and Thron, C.D. (1989). Cyanide release from nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat. Toxicol. Appl. Pharmacol. 99, 354–356.
Kiese, M. (1974). In Methemoglobinemia: A Comprehensive Treatise, pp. 3–7. CRC Press, Cleveland, Ohio.
Kreye, V.A.W., and Reske, S.N. (1982). Possible site of the in vivo disposition of sodium nitroprusside in the rat. Naunyn-Schmiedeberg’s Arch. Pharmacol. 320, 260–265.
Moldeus, P., Hogberg, J. and Orrenius, S. (1978). In Methods in Enzymology (Eds. P.A. Hoffee and M.E.Jones), Vol. 51, pp. 60–71. Academic Press, New York.
Ohkawa, H., Ohkawa, R., Yamamoto, I., and Casida, J.E. (1972). Enzymatic mechanisms and toxicological significance of hydrogen cyanide liberation from various organothiocyanates and organonitriles in mice and houseflies. Pest. Biochem. and Physiol. 2, 95–112.
Smith, R.P., and Kruszyna, H. (1974). Nitroprusside produces cyanide poisoning via a reaction with hemoglobin. J. Pharmacol. Exp. Therap. 191, 557–563.
Tanka, D. and Gatal, K. (1983). Histochemical detection of thiosulphate sulphurtransferase (rhodanese) activity. Histochemistry 77, 285–288.
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© 1991 Plenum Press, New York
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Elguindi, S., O’Brien, P.J. (1991). Cyanide Liberation and Oxidative Stress by Organothiocyanates, Organonitriles and Nitroprusside in Isolated Hepatocytes. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_30
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_30
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