Abstract
Peroxisome proliferator xenobiotics (including clofibrate, a hypolipidaemic drug) are a class of non-genotoxic hepatocarcinogen in sensitive species such as the rat and mouse and result in characteristic liver responses including hepatomegaly, peroxisome proliferation and induction of microsomal cytochrome P450IVA1 (P452)-dependent fatty acid hydroxylase.
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© 1991 Plenum Press, New York
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Chinje, E.C., Gibson, G.G. (1991). Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_29
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_29
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4684-5877-0
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