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Molecular Targets of Chemical Mutagens

  • Chapter
Biological Reactive Intermediates IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 283))

Abstract

Most mutagens are biologically active by virtue of their chemical reactivity. The pioneering work of the Millers (reviewed in Miller and Miller, 1974, 1981) and others (Searle, 1984 and references therein) clearly established that most chemical mutagens (or their metabolites) are electrophilic and covalently bind to cellular macromolecules. Proteins were first identified as cellular targets (Miller, 1951), and it was soon recognized that RNA and DNA are also extensively damaged by mutagens (for reviews see: Searle, 1984; Miller and Miller, 1974). Theoretically, every cellular nucleophile is a potential target for damage by electrophilic mutagens.

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Authors and Affiliations

  1. Department of Chemical Biology, Rutgers University College of Pharmacy, Piscataway, NJ, 08855-0789, USA

    Dr. Bradley D. Preston & Rupa Doshi

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  1. Rutgers University, Piscataway, New Jersey, USA

    Charlotte M. Witmer  & Robert R. Snyder  & 

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  3. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    George F. Kalf  & James J. Kocsis  & 

  4. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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© 1991 Plenum Press, New York

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Preston, B.D., Doshi, R. (1991). Molecular Targets of Chemical Mutagens. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_20

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