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Role of Ca++/Calmodulin binding proteins in Aspergillus nidulans cell cycle regulation

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The goal of this review is to summarise the current knowledge concerning the targets of Ca++ / calmodulin that are essential for cell cycle progression in lower eukaryotes. Emphasis is placed on Aspergillus nidulans since this is the only organism to date shown to posses essential Ca++ dependent calmodulin activated enzymes. Two such enzymes are the calmodulin activated protein phosphatase, calcineurin and the calmodulin dependent protein kinase. These proteins, each the product of a unique gene, are required for progression of quiescent spores into the proliferative cycle and also for execution of the nuclear division cycle in exponentially growing germlings.

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  1. Department of Pharmacology, Duke University Medical Center, 27710, Durham, NC, USA

    Nanda N. Nanthakumar, Jennifer S. Dayton & Anthony R. Means

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  1. Nanda N. Nanthakumar
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  2. Jennifer S. Dayton
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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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Nanthakumar, N.N., Dayton, J.S., Means, A.R. (1996). Role of Ca++/Calmodulin binding proteins in Aspergillus nidulans cell cycle regulation. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_21

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