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Intestinal cell cycle regulation

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-β, which is expressed in the gut epithelium.

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Authors and Affiliations

  1. Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, 77555-0542, USA

    Tien C. Ko

  2. Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas, 77555-0542, USA

    Tien C. Ko, Wade A. Bresnahan & E. Aubrey Thompson

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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Ko, T.C., Bresnahan, W.A., Thompson, E.A. (1997). Intestinal cell cycle regulation. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_4

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7451-0

  • Online ISBN: 978-1-4615-5371-7

  • eBook Packages: Springer Book Archive

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