Abstract
When one speaks of metabolism in the context of biochemical toxicology, one means a quite different thing than the normal definition of metabolism in the context of the cellular processes of energy production and use. Normal cellular metabolism is used to produce energy or cellular constituents, and generally the substrates for normal metabolic reactions are food molecules. In contrast, the metabolism of toxicants which use toxic materials as their substrates do not produce energy, but instead usually require the input of significant energy. They do not produce anything except safety for the cell.
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Garte, S. (1998). Metabolic Susceptibility Genes — Phase 1. In: Genetic Susceptibility to Cancer. Developments in Oncology, vol 79. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4989-5_7
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DOI: https://doi.org/10.1007/978-1-4615-4989-5_7
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