Abstract
Aldehydehydrogenase is a NAD(P)-dependent enzyme with wide distribution virtually in all animal tissues (Vasiliou and Marselos, 1989; Lindahl, 1992). Different consti- tutiveexpressed ALDHs are found in liver, stomach, brain, kidney, skin and eye (Vasil and Marselos, 1989; Pappas et al., 1997). In general, ALDHs are located especially in org with a high content of epithelial cells. An increased interest has been shown r the last years for aldehyde dehydrogenase-3 (ALDH3) activity in the cornea where h higher constitutive specific activity is detected compared to the liver cells (Boesct al., 1996). High levels of ALDH3 activity occurs in the cornea from baboon, cow, hn, opossum, pig and sheep (King and Holmes, 1997). The same study reports also tpresence of ALDH1 as the 1-2% of human lens soluble protein. Furthermore, retina and real pigment epithelial (RPE) cells have been shown to play an important protective role fthe photosensitive cells of the eye against photo- and chemical toxicity.
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References
Boesch, J.S., Lee, C. and Lindahl, R.G.: Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J. Biol. Chem. 271 (1996) 5150–5157.
Bridges, C.D.B.: Retinoids in photosensitive systems. In: The retinoids, Vol 2. Sporn, M.B., Roberts, A.B. and Goodman, D.S., (Eds.), Academic Press, Orlando, FL, (1984) 126–176.
Davis, A., Bernstein, P., Bok, D., Turner, J., Nachtigal, M. and Hunt, R.: A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest. Ophthalmol. Vis. Sci. 36 (1995) 955–964.
De Vito, M.J., Thomas, T., Martin, E., Umbreit, T. and Gallo, M.: Anti-estrogenic action of 2,3,7,8-tetrachlo-rodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice. Toxicol Appl. Pharmacol. 113 (1992) 284–292.
Dunn, K.C., Aotaki-Keen, A.E., Putkey, F.R. and Hjelmeland, L.M.: ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp. Eye Res. 62 (1996) 155–169.
Habig, W.H., Pabst, M.J. and Jakoby, W.B.: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130–7139.
Hunt, R.C. and Davis, A.A.: Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J. Cellular Physiol. 145 (1990) 187–199.
Karageorgou, M., Vasiliou, V, Nebert, D.W. and Marselos, M.: Ligands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthrene. Biochem. Pharmacol. 50 (1995) 2113–2117.
King, G. and Holmes, R.: Human corneal and lens aldehyde dehydrogenases. Adv. Exp. Med. Biol. 414 (1997) 19–27.
Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M.G., Heyman, R.A. and Glass, C.K.: Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371 (1994)528–531.
Leng, X., Blanco, J., Tsai, S.Y., Ozato, K., O’Malley B.W. and Tsai, M.J.: Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements. J. Biol. Chem. 269 (1994)31436–31442.
Lindahl, R.: Aldehyde dehydrogenases and their role in carcinogenesis. CRC Crit. Rev. Biochem. Mol. Biol. 27 (1992)283–335.
Marselos, M.: Genetic variation of drug metabolizing enzymes in the Wistar rat. Acta Pharmacol. Toxicol. 39 (1976)186–197.
Marselos, M., Strom, S.C. and Michalopoulos G.: Effect of phénobarbital and 3-methylcholanthrene on the aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes. Chem-Biol. Inter. 62 (1987)75–88.
Marselos, M. and Vasiliou, V.: Effect of various chemicals on the aldehyde dehydrogenase activity of the rat liver cytosol. Chem-Biol. Interact. 79 (1991) 79–89.
Mosmann T.: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic-ity assays. J. Immun. Methods 65 (1983) 55–63.
Pappas, P., Stephanou, P., Karamanakos, P., Vasiliou, V. and Marselos, M.: Ontogenesis and expression of ALDH activity in the skin and the eye of the rat. Adv. Exp. Med. Biol. 414 (1997) 73–80.
Pavlidis, N.A., Pétris, C, Briassoulis, E., Klouvas, G., Psilas, C, Rempapis, J. and Petroutsos, G.: Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients. Cancer 69 (1992) 2961–2964.
Vasiliou, V, and Marselos, M.: Tissue distribution of inducible aldehyde dehydrogenase activity in the rat after treatment with phénobarbital or methylcholanthrene. Pharmacol. Toxicol. 64 (1989) 39–42.
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Pappas, P., Stephanou, P., Sotiropoulou, M., Murphy, C., Salminen, L., Marselos, M. (1999). Effects of Tamoxifen and Toremifene on ALDH1 and ALDH3 in Human Retinal Pigment Epithelial Cells and Rat Liver. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_18
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