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B-Cell Promoting Activity of Human Colostrum

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Advances in Mucosal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 371))

Abstract

It is well known that human colostrum and milk contain different factors which provide passive immunization for newborn infants.1–3 However, recently it has been shown that human milk may serve as a mechanism by which active immunity can be transferred to the recipient newborn. Free secretory component (SC), lactoferrin, and S-IgA were described as suppressor factors in human colostrum.4–6 At the same time, clinical data suggest the presence in human colostrum and milk of factors, that enhance Ig production. In this paper we have assessed the effect of human colostrum on B cell function of mouse splenocytes. A high-performance liquid chromatography (HPLC) gel-filtration was employed to identify the fraction that associated with B cell-promoting activity of human colostrum.

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Author information

Authors and Affiliations

  1. Laboratory of Immunology, Ukrainian Institute of Pediatrics, Obstetrics and Gynecology, 252050, Kiev, Ukraine

    Igor I. Slukvin, Valentina V. Pilipenko & Victor P. Chernyshov

  2. Institute for Oncology and Radiology Problems, 252022, Kiev, Ukraine

    Alexey A. Philchenkov

Authors
  1. Igor I. Slukvin
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  2. Valentina V. Pilipenko
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  3. Victor P. Chernyshov
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  4. Alexey A. Philchenkov
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky , Michael W. Russell , Susan Jackson  & Suzanne M. Michalek , ,  & 

  2. Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Helena Tlaskalová-Hogenová  & Jaroslav Šterzl  & 

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© 1995 Springer Science+Business Media New York

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Slukvin, I.I., Pilipenko, V.V., Chernyshov, V.P., Philchenkov, A.A. (1995). B-Cell Promoting Activity of Human Colostrum. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_31

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  • DOI: https://doi.org/10.1007/978-1-4615-1941-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5796-4

  • Online ISBN: 978-1-4615-1941-6

  • eBook Packages: Springer Book Archive

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