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The Role of Hydrogen Peroxide as a Signaling Molecule

  • Chapter
Signal Transduction and Cardiac Hypertrophy

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 7))

Summary

Hydrogen peroxide is conventionally regarded as a molecule that is generated in disease conditions and is responsible for inducing significant functional and structural derangement. However, it is becoming increasingly evident that H202 is also expressed in normal healthy tissue and functions as an important signaling molecule. It is involved in complex transcriptional processes that ultimately play a role in inducing cell proliferation or apoptosis. Indeed, it is this unusual dual capacity to serve as a signaling molecule in both promoting and inhibiting cell growth that makes it a particularly interesting focal point for regulatory processes. Ultimately, this results in hydrogen peroxide having an important clinical significance to affect the direction of signaling pathways that will be beneficial or deleterious to the tissue. This paper reviews the present state of our knowledge regarding hydrogen peroxide as a signaling molecule in this context.

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  1. Cell Biology, Laboratory Division of Stroke and Vascular Disease, St. Boniface General Hospital Research Centre and the Dept. of Physiology, University of Manitoba, Winnipeg, Canada

    Michael P. Czubryt & Dr. Grant N. Pierce

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  1. Michael P. Czubryt
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  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director), Larry V. Hryshko PhD (Associate Professor), Elissavet Kardami PhD (Professor) & Pawan K. Singal PhD, DSc (Professor) (Distinguished Professor and Director),  (Associate Professor),  (Professor) &  (Professor)

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Czubryt, M.P., Pierce, G.N. (2003). The Role of Hydrogen Peroxide as a Signaling Molecule. In: Dhalla, N.S., Hryshko, L.V., Kardami, E., Singal, P.K. (eds) Signal Transduction and Cardiac Hypertrophy. Progress in Experimental Cardiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0347-7_19

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