Strain Differences II: Nicotine, Anxiolytics, Convulsants, and Amnesics

Abstract

The investigations of Anisman, summarized in Table X, have brought us a long way from the study of simple strain differences in response to amphetamine (and scopolamine) in rodents, but it is to such that we must now return with respect to agents of this kind. Oliverio et al. (1966) reported data on a differential effect of a 2.7 mg/kg dose of scopolamine on avoidance conditioning depending on strain: DBA mice showed a tenfold increase in avoidance responses, whereas merely a threefold increase was found for C3H/He subjects. But the interactive effect depended on original performance level: Well trained mice of both strains showed, by contrast, a similar (and considerable) decrement.