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Regulation of Intracellular Free Calcium

  • Chapter
Molecular Biology of Membrane Transport Disorders

Abstract

It can be argued that the calcium ion is the oldest recognized signal transduction molecule, whether one dates the birth of this recognition with Ringer’s 1883 studies1 on the requirement for extracellular Ca2+ in myocardial contraction, or with Heilbrunn’s much later proposal2 that Ca2+ is the physiological inducer of muscle contraction. Perhaps because of this early focus on calcium’s role in contractility in particular, and in the function of classically “excitable” cells generally (such as Katz and Miledi’s seminal studies on the role of Ca2+ in neurotransmitter release3), the first 100 years of cell calcium research was dominated by efforts to understand how transient changes in intracellular free Ca2+ activity ([Ca2+]i) are achieved and transduced in but two very specialized cell types—muscle and neuron.

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Authors and Affiliations

  1. Department of Biology, The Johns Hopkins University, Baltimore, Maryland, 21218, USA

    William B. Busa

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  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Busa, W.B. (1996). Regulation of Intracellular Free Calcium. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_21

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_21

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  • Print ISBN: 978-1-4612-8446-8

  • Online ISBN: 978-1-4613-1143-0

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