Skip to main content
SpringerLink
Log in

IL1 Beta Impairs Relational but Not Procedural Rodent Learning in a Water Maze Task

  • Chapter
AIDS, Drugs of Abuse, and the Neuroimmune Axis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 402))

Abstract

The behavioral signs of infectious illness have been well-documented. They typically include anorexia, somnolence, decreased locomotor activity, decreased social and novel stimulus exploration, and decreased sexual behavior (Hart, 1988; Bluthe, Dantzer, and Kelley, 1991; 1992). It is thought that sickness behavior represents an organized set of responses that conserves metabolic energy, making it available for the febrile response (Hart, 1988; Dantzer, Bluthe, Kent, & Kelley, 1992). Proinflammatory cytokines secreted by activated macrophages and other immunocompetent cells appear to mediate sickness (Bluthe, Dantzer,& Kelley, 1991; Crestani, Seguy, & Dantzer, 1991; Cunningham & DeSouza, 1993; Spadaro & Dunn, 1990; Kent, Bluthe, Dantzer, Hardwick, Kelley, Rothwell, & Vannice, 1992; Masotto, Caspani, Grazia deSimone, Mengozzi, Scatturni, Sironi, Carenzi, & Ghezzi, 1992).Among these cytokines, interleukin-1-beta (IL1β) represents a major ascending communication link between the peripheral immune system and the central nervous system (e.g., Hall, O’Grady, & Menzies, 1992; Komaki, Arimura, and Koves, 1992).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aubert, A., Vega, C., Dantzer, R., and Goodall, G. (1995). Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain,Behavior and Immunity, 9(2), 129–148.

    Article  CAS  Google Scholar 

  • Ban, E., Haour, F., & Lenstra, R. (1992). Brain interleukin 1 gene expression induced by peripheral lipopolysac-charide administration. Cytokine, 4, 48–54.

    Article  PubMed  CAS  Google Scholar 

  • Bellinger, F.P., Madamba, S., & Siggins, G.R. (1993). Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Res, 628, 227–234.

    Article  PubMed  CAS  Google Scholar 

  • Betancur, C., Lledo, A., Borrell, J., & Guaza, C. (1994). Corticosteroid regulation of IL-1 receptors in the mouse hippocampus: effects of glucocorticoid treatment, stress, and adrenalectomy. Neuroendocrinology, 59, 120–128.

    Article  PubMed  CAS  Google Scholar 

  • Bluthe, R.M., Dantzer, R., & Kelley, K.W. (1989). CRF is not involved in the behavioral effects of peripherally injected interleukin-1 in the rat. Neuroscience Research Communications, 5, 149–154.

    CAS  Google Scholar 

  • Bluthe, R.M., Dantzer, R., & Kelley, K.W. (1992). Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res, 573, 318–320.

    Article  PubMed  CAS  Google Scholar 

  • Bluthe, R.M., Dantzer, R., & Kelley, K.W. (1991). Interleukin-1 mediates behavioral but not metabolic effects of tumor necrosis factor a in mice. European Journal of Pharmacology, 209, 281–283.

    Article  PubMed  CAS  Google Scholar 

  • Brandeis, R., Brandys, Y., & Yehuda, S. (1989). The use of the Morris water maze in the study of memory and learning. International Journal of Neuroscience, 48, 29–69.

    Article  PubMed  CAS  Google Scholar 

  • Bret-Dibat, J.. Bluthe, R., Kent, S., Kelley, K.W., and Dantzer, R. (1995). Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism. Brain,Behavior,and Immunity, 9(3); 242–246.

    Article  PubMed  CAS  Google Scholar 

  • Crestani, F., Seguy, F., and Dantzer, R. (1991). Behavioral effects of peripherally injected interleukin-1: role of prostaglandins. Brain Research, 542, 330–335.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, E.T. and De Souza, E.B. (1993). Interleukin 1 receptors in the brain and endocrine tissues. Immunology Today, 14(4), 171–176.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, E.T.J., Wada, E., Carter, D.B., Tracey, D.E., Battey, J.F., & De Souza, E.B. (1991). Localization of interleukin-1 receptor messenger RNA in murine hippocampus. Endocrinology, 128, 2666–2668.

    Article  PubMed  CAS  Google Scholar 

  • de Kloet, E.R., Oitzl, M.S., & Schobitz, B. (1994). Cytokines and the brain corticosteroid receptor balance: relevance to pathophysiology of neuroendocrine-immune communication. Psvchoneuroendocrinology, 19, 121–134.

    Article  Google Scholar 

  • Dantzer, R., Bluthe, R., Kent, S. and Kelley, K.W. (1992). Behavioral effects of cytokines. In N.J. Rothwell and R.D. Dantzer (Eds.) Interleukin-1 in the brain. Pergamon Press: Tarrytown, NY.

    Google Scholar 

  • Dinarello, C.A. (1991). Interleukin-I and interleukin-1 antagonism. Blood, 77(8): 1627–1652.

    PubMed  CAS  Google Scholar 

  • Dunn, A.J. (1989). Psychoneuroimmunology for the psychoneuroendocrinologist: A review of animal studies of nervous system-immune system interactions. Psychoneuroendocrinology, 14(4); 251–274.

    Article  PubMed  CAS  Google Scholar 

  • Eichenbaum, H., Matthews, P., Cohen, N.J. (1989). Further studies of hippocampal representation during odor discrimination learning. Behavioral Neuroscience, 103: 1207–1216.

    Article  PubMed  CAS  Google Scholar 

  • Fent, K., Zbinden, G. (1987). Toxicity of interferon and interleukin. TIPS, 8, 100–104.

    CAS  Google Scholar 

  • Fordyce, D.E. & Wehner, J.M. (1993). Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Res, 619, 111–119.

    Article  PubMed  CAS  Google Scholar 

  • Gibertini, M., Newton, C., Friedman, H., Klein, T.W. (1995). Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-ß. Brain,Behavior and Immunity, 9(2), 1113–128.

    Article  Google Scholar 

  • Gottschall, P.E., Komaki, G., and Arimura, A. (1992). Interleukin-1 activation of the central nervous system. In N.J. Rothwell and R.D. Dantzer (Eds.) Interleukin-1 In the Brain. Pergamon Press: Tarrytown, NY.

    Google Scholar 

  • Gutierrez, E.G., Banks, W.A., & Kastin, A.J. (1993). Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. JNeuroimmunol, 47, 169–176.

    Article  CAS  Google Scholar 

  • Hall, N.R.S., O’Grady, M.P. and Menzies, R.A. (1992). Cytokines and the central nervous system: links with mental disorders. in R. Kvetnansky, McCarty, R., and Axelrod, J. (Eds.) Stress: Neuroendocrine and Molecular Approaches. Gordon and Breach Science Publishers: New York.

    Google Scholar 

  • Hart, B. L. (1988). Biological basis of the behavior of sick animals. Neuroscience and Biobehavioral Reviews, 12; 123–137.

    Article  PubMed  CAS  Google Scholar 

  • Katsuki, H., Nakai, S., Hirai, Y., Akaji, K., Kiso, Y., & Satoh, M. (1990). Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur J Pharmacol, 181, 323–326.

    Article  PubMed  CAS  Google Scholar 

  • Kent, S., Bluthe, R.M., Dantzer, R., Hardwick, A.J., Kelley, K.W., Rothwell, N.J., & Vannice, J.L. (1992). Different receptor mechanisms mediate the pyrogenic and behavioral effects of Interleukin 1. Proc Natl Acad Sci USA, 89, 9117–9120.

    Article  PubMed  CAS  Google Scholar 

  • Komaki, G., Arimura, A., & Koves, K. (1992). Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis. Am JPhysiol, 262, E246 - E251.

    CAS  Google Scholar 

  • Linthorst, A.C., Flachskamm, C., Holsboer, F., & Reul, J.M. (1994). Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature. Endocrinology, 135, 520–532.

    Article  PubMed  CAS  Google Scholar 

  • Masotto, C., Caspani, G., Grazia deSimone, M., Mengozzi, M., Scatturni, M., Sironi, M., Carenzi, A., and Ghezzi, P. (1992). Evidence for a different sensitivity to various central effects of interleukin- I in mice. Brain Research Bulletin, 28(2), 161–165.

    Article  PubMed  CAS  Google Scholar 

  • Messing, R.B., Kieven, M.S., & Sparber, S.B. (1986). Delaying reinforcement in an autoshaping task generates adjunctive and superstitious behaviors. Behavioral Processes, 13; 327–338.

    Article  Google Scholar 

  • McDonald, R.J. and White, N.M. (1993). A triple dissociation of memory systems: Hippocampus, amygdala, and dorsal striatum. Behavioral Neuroscience, 107 (1); 3–22.

    Article  PubMed  CAS  Google Scholar 

  • McNamara, R.K. & Skelton, R.W. (1993). The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res Brain Res Rev, 18, 33–49.

    Article  PubMed  CAS  Google Scholar 

  • Morganti-Kosssmann, M.C., Kossmann, T., & Wahl, S.M. (1992). Cytokines and neuropathology. Trends Pharmacol Sci, 13, 286–291.

    Article  Google Scholar 

  • Morris, R.G.M. (1981). Spatial localization does not require the presence of local cues. Leaning and Motivation, 12: 239–260.

    Article  Google Scholar 

  • Oitzl, M.S., van Oers, H., Schobitz, B., & de Kloet, E.R. (1993). Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning. Brain Res, 613, 160–163.

    Article  PubMed  CAS  Google Scholar 

  • Plata-Salaman, C.R. & ffrench-Mullen, J.M. (1992). Interleukin-1 beta depresses calcium currents in CAI hippocampal neurons at pathophysiological concentrations. Brain Res Bull, 29, 221–223.

    Article  PubMed  CAS  Google Scholar 

  • Plata-Salaman, C.R. & ffrench-Mullen, J.M. (1994). Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C. Eur JPharmacol, 266, 1–10.

    CAS  Google Scholar 

  • Rada, P., Mark, G.P., Vitek, M.P., Mangano, R.M., Blume, A.J., Beer, B., & Hoebel, B.G. (1991). Interleukin-I beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res, 550, 287–290.

    Article  PubMed  CAS  Google Scholar 

  • Schacter, D.L. (1985). Multiple forms of memory in humans and animals. In N.M. weinberger, J.L. McGaugh, and G. Lynch (Eds.) Memory Systems of the Brain. Guilford Press: New York.

    Google Scholar 

  • Schobitz, B., Sutanto, W., Carey, M.P., Holsboer, F., & de Kloet, E.R. (1994). Endotoxin and interleukin 1 decrease the affinity of hippocampal mineralocorticoid (type I) receptor in parallel to activation of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology, 60, 124–133.

    Article  PubMed  CAS  Google Scholar 

  • Smith, A., Tyrrell, D., Coyle, K., and Higgins, P. (1988). Effects of interferon alpha in man: a preliminary report. Psychopharmacology, 96, 414–416.

    Article  PubMed  CAS  Google Scholar 

  • Spadaro, F., and Dunn, A.J. (1990). Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment. Brain, Behavior,and Immunity, 4, 308–322.

    Article  CAS  Google Scholar 

  • Sparber, S.B., Bollweg, G.L., & Messing, R.B. (1991). Food deprivation enhances both autoshaping and autoshaping impairment by a latent inhibition procedure. Behavioral Processes, 23; 59–74.

    Article  Google Scholar 

  • Squire, L.R. (1992). Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans Psychological Review, 99(2); 195–231.

    Article  PubMed  CAS  Google Scholar 

  • Squire, L.R., Knowlton, B., & Musen, G. (1993). The structure and organization of memory. Annual Review ofPsycholog, 44; 453–495.

    Article  CAS  Google Scholar 

  • Squire, L.R. & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253; 1380–1385.

    Article  PubMed  CAS  Google Scholar 

  • Takao, T., Tracey, D.E., Mitchell, W.M., & De Souza, E.B. (1990). Interleukin-1 receptors in mouse brain: characterization and neuronal localization. Endocrinology, 127, 3070–3078.

    Article  PubMed  CAS  Google Scholar 

  • Upchurch, M. and Wehner, J. M. (1988). Differences between inbred strains of mice in Morris water maze performance. Behavior Genetics, 18(1), 55–68.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, Y., Klein, T.W., & Friedman, H. (1993). Legionella and macrophages. In B.S. Zwilling and T.K. Eisenstein (Eds.) Macrophage-Pathogen Interaction. pp. 329–348, Marcel Dekker, Inc., New York, NY

    Google Scholar 

  • Yamamoto, Y., Klein, T.W., Newton, C.A., & Friedman, H. (1992). Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection. J. Immunol, 148, 584–589.

    PubMed  CAS  Google Scholar 

  • Yamamoto, Y., Klein, T.W., Newton, C.A., Widen, R., & Friedman, H. (1988). Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect Immun, 56, 370–375.

    PubMed  CAS  Google Scholar 

  • Zalcman, S., Green-Johnson, J.M., Murray, L., Nance, D.M., Dyck, D., Anisman, H.. & Greenberg, A.H. (1994). Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res, 643, 40–49.

    Article  PubMed  CAS  Google Scholar 

  • Zola-Morgan, S. & Squire, L.R. (1993). Neuroanatomy of memory. Annual Review of Neuroscience, 16: 547–463.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Midwest Research Institute, 425 Volker Blvd., Kansas City, Missouri, 64110, USA

    Michael Gibertini

Authors
  1. Michael Gibertini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Herman Friedman

  2. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  3. Emory University, Atlanta, Georgia, USA

    John Madden

  4. Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA

    Burt M. Sharp

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Gibertini, M. (1996). IL1 Beta Impairs Relational but Not Procedural Rodent Learning in a Water Maze Task. In: Friedman, H., Eisenstein, T.K., Madden, J., Sharp, B.M. (eds) AIDS, Drugs of Abuse, and the Neuroimmune Axis. Advances in Experimental Medicine and Biology, vol 402. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0407-4_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0407-4_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8038-2

  • Online ISBN: 978-1-4613-0407-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation