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Prostate-Specific Antigen

  • Chapter
Serological Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 11))

Abstract

The single most important development in clinical cancer markers since the early 1970s, when carcinoembryonic antigen (CEA) was approved by the Food and Drug Administration, is the approval of a prostate-specific antigen (PA or PSA) as a cancer-marker test for adenocarcinoma of the prostate in 1985. In fact, whatever CEA can do for gastrointestinal cancer, PSA can do, and do it better, for prostate cancer. The clinical application of PSA in diagnosis, prognosis, and monitoring of prostate cancer is the subject of this chapter. Basic characteristics of this marker of prostate cancer also will be reviewed. Reviews of similar topic are available elsewhere (Wang et al., 1982; Chu, 1985, 1990; Chu and Murphy, 1986; Brawer and Lange, 1989; Catalona et al., 1989; Killian and Chu, 1990). It should be noted that PSA is not a neoantigen of prostate cancer or a prostate cancer specific antigen; rather, it is expressed equally, but exclusively, by normal, benign hyperplastic and cancerous prostate glands (Wang et al., 1979; Papsidero et al., 1981).

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Authors
  1. T. Ming Chu
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

    Stewart Sell

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© 1992 Springer Science+Business Media New York

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Chu, T.M. (1992). Prostate-Specific Antigen. In: Sell, S. (eds) Serological Cancer Markers. Contemporary Biomedicine, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0401-5_5

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  • DOI: https://doi.org/10.1007/978-1-4612-0401-5_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6745-4

  • Online ISBN: 978-1-4612-0401-5

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