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Glucokinase Gene Expression and Regulation

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Molecular Biology of Diabetes

Summary

Diabetes investigators have been interested in the regulation of glucokinase for years because this enzyme catalyzes the initial step in glucose metabolism by the liver and pancreatic β-cell. However, now that mutations in the glucokinase gene have been associated with early-onset noninsulin-dependent diabetes mellitus, there is increased interest in the mechanisms that enable the gene to be differentially regulated in a cell-specific manner. In this chapter, we provide an overview of our current knowledge of the mechanisms by which the glucokinase gene is regulated and how glucokinase gene mutations might cause the hyperglycemia associated with certain types of diabetes.

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Authors
  1. Mark A. Magnuson
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  2. Kevin D. Niswender
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  3. Cathleen C. Pettepher
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Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Boris Draznin MD, PhD

  2. National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA

    Derek LeRoith MD, PhD

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© 1994 Springer Science+Business Media New York

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Magnuson, M.A., Niswender, K.D., Pettepher, C.C. (1994). Glucokinase Gene Expression and Regulation. In: Draznin, B., LeRoith, D. (eds) Molecular Biology of Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0241-7_7

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  • DOI: https://doi.org/10.1007/978-1-4612-0241-7_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6677-8

  • Online ISBN: 978-1-4612-0241-7

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