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Hairpin Nanoprobes for Gene Detection

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BioMEMS and Biomedical Nanotechnology

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Abstract

First hypothesized by Crick in 1958 [1], the central of dogma of biology states that DNA begets messengerRNA, which is then translated into protein. The ability to monitor this gene expression process and measure quantitatively the expression levels of mRNA can provide tremendous insight into normal and diseased states of living cells, tissues and animals, and clues to maintaining health and curing diseases. The first demonstration of mRNA being complementary to a gene and responsible for protein translation [2] was made by Hall and Spiegelman using a nucleic acid hybridization assay in which the reconstitution of the double-strandedDNAstructure occurs only between perfect, or near-perfect complementary DNA strands, leading to a method of detecting complementary nucleotide sequences. In many ways this method is the precursor to both polymerase chain reaction (PCR) and other modern hybridization assays.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332

    Philip Santangelo, Nitin Nitin, Leslie LaConte & Gang Bao

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  1. Philip Santangelo
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  2. Nitin Nitin
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  3. Leslie LaConte
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  2. Anderson Cancer Center, University of Texas M.D., Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  5. Texas Alliance for NanoHealth, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  6. Dept. of Electrical Engineering, University of California Riverside, Riverside, California, USA

    Mihrimah Ozkan

  7. Dept. of Bioengineering, University of California, San Diego La Jolla, California, USA

    Michael J. Heller

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Santangelo, P., Nitin, N., LaConte, L., Bao, G. (2006). Hairpin Nanoprobes for Gene Detection. In: Ferrari, M., Ozkan, M., Heller, M.J. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25843-0_12

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  • DOI: https://doi.org/10.1007/978-0-387-25843-0_12

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