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Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action

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Coordination Compounds: Synthesis and Medical Application

Part of the book series: Structure and Bonding ((STRUCTURE,volume 67))

Abstract

An overview is presented of platinum amine compounds, used as antitumor drugs. The history of the discovery is briefly described, including a discussion of the synthesis of platinum amine coordination compounds. Attention is given to the relationship between biological activity and structure of the compounds, especially to the nature of the ligands coordinated to platinum. The primary biological event appears to be the interaction with nucleic acids, and therefore the major part of the review is deals with studies of the binding interactions of platinum amine compounds (active and inactive ones) to nucleic acids and nucleic acid fragments. Studies on mononucleic acid fragments have made clear that a strong preference exists for binding at guanine-N7 sites. Studies on oligonucleotides have shown that, when two neighboring guanines are present, chelation of the cis-Pt(NH3)2 unit is strongly favored above all other possibilities. However, binding at neighboring AG-units also occurs readily. Studies on DNA (in vivo and in vitro) have shown that similar bindings occur in DNA and oligonucleotides, and that the DNA is distorted in a similar manner to double-stranded oligonucleotides.

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Authors and Affiliations

  1. Department of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300, RA Leiden, The Netherlands

    Jan Reedijk

  2. Medical Biological Laboratory, TNO, 2280, AA Rijswijk, The Netherlands

    Anne Marie J. Fichtinger-Schepman

  3. Department of Clinical Oncology, Leiden University, The Netherlands

    Allan T. van Oosterom

  4. Biochemical Laboratory, Leiden University, The Netherlands

    Piet van de Putte

Authors
  1. Jan Reedijk
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  2. Anne Marie J. Fichtinger-Schepman
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  3. Allan T. van Oosterom
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  4. Piet van de Putte
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© 1987 Springer-Verlag

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Reedijk, J., Fichtinger-Schepman, A.M.J., van Oosterom, A.T., van de Putte, P. (1987). Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action. In: Coordination Compounds: Synthesis and Medical Application. Structure and Bonding, vol 67. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-17881-3_2

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  • DOI: https://doi.org/10.1007/3-540-17881-3_2

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  • Print ISBN: 978-3-540-17881-1

  • Online ISBN: 978-3-540-47897-3

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