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Microwave-Enhanced High-Speed Fluorous Synthesis

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Microwave Methods in Organic Synthesis

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 266))

Abstract

Increasing reaction speed and simplifying product purification are two major ways to improve the efficiency of organic synthesis. A new technology for high-speed solution-phase synthesis has been developed by combination of microwave heating and fluorous purification. This review describes different techniques for microwave-enhanced fluorous synthesis and their applications in Pd-catalyzed cross-coupling reactions, free-radical reactions, multicomponent reactions, and compound library synthesis.

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Abbreviations

μw:

microwave

HTS:

high-throughput synthesis

SPOS:

solid-phase organic synthesis

FTI:

Fluorous Technologies, Inc.

Rf n h m :

C n F2 n+1(CH2) m

F-LLE:

fluorous liquid–liquid extractions

F-SPE:

fluorous solid-phase extraction

HPLC:

high-performance liquid chromatography

TLC:

thin-layer chromatography

IR:

infrared spectroscopy

NMR:

nuclear magnetic resonance

LCMS:

liquid chromatography and mass spectrometry

BINAP:

2,2′-bis(diphenylphosphino)-1,1′-binaphthyl

BTF:

benzotrifluoride

MCR:

multicomponent reaction

DOS:

diversity-oriented synthesis

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Acknowledgments

Parts of author's work were supported by National Institutes of General Medical Sciences SBIR Grants (2R44GM062717-02 and 2R44GM067326-02). The Pd-catalyzed microwave reactions were conducted under license to US patent 6,136,157 and European patent No. 0901453 held by Personal Chemistry, now Biotage.

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Authors and Affiliations

  1. Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, 15238, Pittsburgh, PA, USA

    Wei Zhang

Authors
  1. Wei Zhang
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Correspondence to Wei Zhang .

Editor information

Mats Larhed Kristofer Olofssonq

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© 2006 Springer-Verlag Berlin Heidelberg

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Zhang, W. (2006). Microwave-Enhanced High-Speed Fluorous Synthesis. In: Larhed, M., Olofssonq, K. (eds) Microwave Methods in Organic Synthesis. Topics in Current Chemistry, vol 266. Springer, Berlin, Heidelberg . https://doi.org/10.1007/128_045

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