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Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

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Abstract

In this work, we proposed a research hypothesis which mainly focuses on the role of gut microbiota, in relation with chronic kidney disease, existing in the village of Uddanam belonging to the State of Andhra Pradesh, India. Earlier studies conducted on various physical and chemical parameters, such as food, water, soil and pesticides, could not find the exact cause of the aetiology of the disease. As there were no physical and chemical causative factors identified, this disease was hence named as mysterious Uddanam kidney nephropathy of unknown origins. There are few scientific pieces of evidence available in the literature, which suggests the role of gut microbiome dysbiosis and its impact on kidney disease. Such kinds of scientific studies which deal with the analysis of microbial communities of the gut region and identification of dysbiosis were not performed in the case of Uddanam kidney nephropathy. Thus, through this paper, we propose a hypothesis to analyse and establish the relationship between the gut dysbiosis and renal failure by performing the metagenomics study between the patients and the normal individuals. To the best of our knowledge, there are no reports available to date on the dysbiosis of the gut microbiome and its impact on Uddanam nephropathy and hence this research hypothesis is thus proposed.

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Acknowledgements

The corresponding author thanks the Institute of Bioinformatics and Computational Biology (IBCB), Visakhapatnam, Andhra Pradesh, India, for its help in securing the news for local incidences of this study. The corresponding is also thankful for Chaitanya Bharathi Institute of Technology (CBIT), Gandipet, Hyderabad, Telangana for providing the facilities to communicate this manuscript.

Funding

Research in YA lab is funded by the Department of Biotechnology (Ministry of Science & Technology, Government of India) and Indian Council of Medical Research.

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Authors and Affiliations

  1. Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad, Telangana, India

    P. V. Parvati Sai Arun & C. Obula Reddy

  2. Institute of Bioinformatics and Computational Biology, Visakhapatnam, Andhra Pradesh, India

    P. V. Parvati Sai Arun

  3. Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

    Yusuf Akhter

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  1. P. V. Parvati Sai Arun
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Correspondence to P. V. Parvati Sai Arun.

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Parvati Sai Arun, P.V., Obula Reddy, C. & Akhter, Y. Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective. SN Compr. Clin. Med. 1, 23–25 (2019). https://doi.org/10.1007/s42399-018-0008-5

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