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Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Diabetes mellitus is a metabolic disorder caused by impaired glucose metabolism. Coenzyme Q10 is an endogenous vitamin with significant antioxidant properties.

Aims and objective

The aim of our study is to investigate the protective effect of coenzyme Q10 against streptozotocin-induced diabetic rats.

Materials and methods

Five groups of rats were used as follows: normal control (given normal saline), diabetic control (STZ 50 mg/kg b.w., i.p.), coenzyme Q10-treated diabetic rats (10 mg/kg b.w.), glibenclamide-treated diabetic rats (0.6 mg/kg b.w.) as standard group, and drug alone-treated group (coenzyme Q10 10 mg/kg b.w.). The rats were sacrificed after the study duration of 30 days. Biochemical and antioxidant parameters and histopathological evaluation were carried out in experimental rats.

Results and discussion

The diabetic control group showed significant alterations in biochemical and histological parameters. Coenzyme Q10 was able to bring back the altered parameters to normal levels which were similar to that of the glibenclamide-treated group.

Conclusion

Coenzyme Q10 could, therefore, be used as an adjunct in the management of diabetes.

Antidiabetic activity of conenzyme Q10

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Acknowledgements

The authors are thankful to VIT University for providing the necessary facilities to carry out this research project.

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Authors and Affiliations

  1. School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, 632014, India

    Jerine S. Peter,  Giridharan R, Kadar S. Basha, Udhaya B. Lavinya & Sabina Evan Prince

  2. ACS Medical College and Hospital, Chennai, Tamil Nadu, 600077, India

    Shalini M

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  1. Jerine S. Peter
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  2. Shalini M
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  3. Giridharan R
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  4. Kadar S. Basha
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  6. Sabina Evan Prince
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Correspondence to Sabina Evan Prince.

Ethics declarations

The experiment was carried out under the guidelines of CPCSEA, and the ethical clearance number is VIT/IAEC/11th/October 10th/No. 26.

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The authors declare that they have no conflict of interest.

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Peter, J.S., Shalini M, Giridharan R et al. Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators. Int J Diabetes Dev Ctries 40, 143–152 (2020). https://doi.org/10.1007/s13410-019-00752-z

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  • DOI: https://doi.org/10.1007/s13410-019-00752-z

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