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Rhinocerebral Mucormycosis: A Retrospective Study

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Mucormycosis is an acute often fatal infection caused by fungi of family mucoracea (Kauffman and Malani Curr Infect Dis Rep 9(6):435–440). The principal pathogens in this family are rhizopus, mucor and absidia species. Mucoracea are found in soil, decaying vegetation and other organic matter. Mucormycosis is a polymorphic disease with diverse clinical manifestation. It is divided into rhinocerebral, pulmonary, cutaneous, cardiac, gastrointestinal and disseminated. Rhinocerebral mucormycosis the most commonest manifestation of mucormycosis is usually a fatal fulminant infection. Rhinocerebral mucormycosis can be further divided into rhino-maxillary and rhino-orbito-cerebral. The disease commonly occur in diabetics who have ketoacidosis but is also seen in severely debilitated or immunosuppressed patients. It has also been reported from otherwise normal individuals. Early diagnosis and treatment is mandatory for a successful management of this infection.

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References

  1. Kauffman CA, Malani AN (2007) Zygomycosis: an emerging fungal infection with new options for management. Curr Infect Dis Rep 9(6):435–440

  2. Leitner C, Hoffmann J, Zerfowski M, Reinert S (2003) Mucormycosis: necrotizing soft tissue lesion of the face. J Oral Maxillofac Surg 61:1354–1358

  3. Roden MM, Zaoutis TE, Buchanan WL et al (2005) Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 41(5):634–653

  4. McNulty JS (1982) Rhinocerebral mucormycosis: predisposing factors. Laryngoscope 92(10):1140–1143

  5. Petrikkos G, Skiada A, Lortholary O et al (2012) Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis 54(Suppl 1):S23–S34

  6. Lanternier F, Sun HY, Ribaud P et al (2012) Mucormycosis in organ and stem cell transplant recipients. Clin Infect Dis 54(11):1–8

  7. Aslani J, Eizadi M, Kardavani B et al (2007) Mucormycosis after kidney transplantations: report of seven cases. Scand J Infect Dis 39(8):703–706

  8. Xia ZK, Wang WL, Yang RY (2013) Slowly progressive cutaneous, rhinofacial and pulmonary mucormycosis caused by mucor irregularis in an immunocompetant woman. Clin Infect Dis 56(7):993–995

  9. Gale GR, Welch AM (1961) Studies of opportunistic fungi: I. Inhibition of Rhizopus oryzae by human serum. Am J Med Sci 241(5):604–612

  10. Ferguson BJ (2000) Mucormycosis of the nose and paranasal sinuses. Otolaryngol Clin North Am 33(2):349–365

  11. Rajagopalan S (2005) Serious infections in elderly patients with diabetes mellitus. Clin Infect Dis 40(7):990–996

  12. Harril WC, Stewart MG, Lee AG, Cernoch P (1996) Chronic rhinocerebral mucormycosis. Laryngoscope 106(10):1292–1297

  13. Walsch TJ, Gamaletsou MN, Mcginnis MR et al (2012) Early clinical and laboratory diagnpsis of invasive pulmonary, extrapulmonary and disseminated mucormycosis. Clinical Inf dis 54(Suppl 1):S55–S60

  14. Spellberg B, Walsh TJ, Kontoyiannis DP et al (2009) Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis 48(12):1743–1751

  15. Strasser MD, Kennedy RJ, Adam RD (1996) Rhinocerebral mucormycosis: therapy with amphotericin B lipid complex. Arch Intern Med 156(3):337–339

  16. van Burik JA, Hare RS, Solomon HF et al (2006) Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin Infect Dis 42:e61–e65

  17. Shah PD, Peters KR, Reuman PD (1997) Recovery from rhinocerebral mucormycosis with carotid artery occlusion: a pediatric case and review of the literature. Pediatr Infect Dis J 16(1):68–71

  18. Weprin BE, Hall WA, Goodman J, Adams GL (1998) Long-term survival in rhinocerebral mucormycosis: case report. J Neurosurg 88(3):570–575

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Correspondence to Jyoti Shailesh Kolekar.

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Kolekar, J.S. Rhinocerebral Mucormycosis: A Retrospective Study. Indian J Otolaryngol Head Neck Surg 67, 93–96 (2015). https://doi.org/10.1007/s12070-014-0804-5

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  • DOI: https://doi.org/10.1007/s12070-014-0804-5

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