Abstract
The need to maximize agricultural productivity has made pesticides an indispensable part of current times. Farmers are unaware of the lurking consequences of the pesticide exposure, which endanger their health. It also puts the unsuspecting consumers in peril. The pesticides (from organophosphates, organochlorine, and carbamate class) disrupt the immune and hormonal signaling, causing recurrent inflammation, which leads to a wide array pathologies, including teratogenicity. Numerous farmers have fallen victim to neural disorders–driven suicides and lungs, prostate/breast cancer–caused untimely deaths. Green revolution which significantly escalated agricultural productivity is backfiring now. It is high time that environmental and agricultural authorities act to restrain the excessive usage of the detrimental chemicals and educate farmers regarding the crisis. This review discusses the biological mechanisms of pesticide-driven pathogenesis (such as the activation or inhibition of caspase, serine protease, acetylcholinesterase) and presents the pesticide-exposure-caused health deterioration in USA, India, and Africa. This holistic and critical review should be an eye-opener for general public, and a guide for researchers.
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References
Abdo W, Hirata A, Sakai H, el-Sawak A, Nikami H, Yanai T (2013) Combined effects of organochlorine pesticides heptachlor and hexachlorobenzene on the promotion stage of hepatocarcinogenesis in rats. Food Chem Toxicol 55:578–585. https://doi.org/10.1016/j.fct.2013.01.035
Ahmadi FA, Linseman DA, Grammatopoulos TN et al (2003) The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem 87:914–921. https://doi.org/10.1046/j.1471-4159.2003.02068.x
Aktar MW, Sengupta D, Chowdhury A (2009) Impact of pesticides use in agriculture: their benefits and hazards. Interdiscip Toxicol 2:1–12. https://doi.org/10.2478/v10102-009-0001-7
Atlas SA (2007) The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J Manag Care Pharm 13:9–20. https://doi.org/10.18553/jmcp.2007.13.s8-b.9
Aung T, Bisognano JD, Morgan MA (2010) Allergic respiratory disease as a potential co-morbidity for hypertension. Cardiol J 17:443–447
Banerjee I, Tripathi S, As R, Sengupta P (2014) Pesticide use pattern among farmers in a rural district of West Bengal, India. J Nat Sci Biol Med 5:313. https://doi.org/10.4103/0976-9668.136173
Bates GW, Legro RS (2013) Longterm management of Polycystic Ovarian Syndrome (PCOS). Mol Cell Endocrinol 373:91–97. https://doi.org/10.1016/j.mce.2012.10.029
Beecham JE, Seneff S (2016) Is there a link between autism and glyphosate-formulated herbicides? J Autism 3:1. https://doi.org/10.7243/2054-992X-3-1
Behere PB, Bhise MC (2009) Farmers’ suicide: across culture. Indian J Psychiatry 51:242–243. https://doi.org/10.4103/0019-5545.58286
Blakemore J, Naftolin F (2016) Aromatase: contributions to physiology and disease in women and men. Physiology (Bethesda) 31:258–269. https://doi.org/10.1152/physiol.00054.2015
Brain RA, Solomon KR (2009) Comparison of the hazards posed to amphibians by the glyphosate spray control program versus the chemical and physical activities of coca production in Colombia. J Toxicol Environ Health A 72:937–948
Burow KR, Shelton JL, Dubrovsky NM (2008) Regional nitrate and pesticide trends in ground water in the eastern San Joaquin Valley, California. J Environ Qual 37:S249–S263. https://doi.org/10.2134/jeq2007.0061
Cao S, Liu P, Zhu H, Gong H, Yao J, Sun Y, Geng G, Wang T, Feng S, Han M, Zhou J, Xu Y (2015) Extracellular acidification acts as a key modulator of neutrophil apoptosis and functions. PLoS One 10:e0137221. https://doi.org/10.1371/journal.pone.0137221
Carmichael SL, Yang W, Roberts E, Kegley SE, Brown TJ, English PB, Lammer EJ, Shaw GM (2016) Residential agricultural pesticide exposures and risks of selected birth defects among offspring in the San Joaquin Valley of California. Birth Defects Res Part A Clin Mol Teratol 106:27–35. https://doi.org/10.1002/bdra.23459
Casida JE (2010) Pest toxicology: the primary mechanisms of pesticide action. In: Hayes’ handbook of pesticide toxicology, pp 103–117
Chitra GA, Muraleedharan VR, Swaminathan T, Veeraraghavan D (2006) Use of pesticides and its impact on health of farmers in South India. Int J Occup Environ Health 12:228–233. https://doi.org/10.1179/oeh.2006.12.3.228
Chowdhury AN, Banerjee S, Brahma A, Weiss MG (2007) Pesticide practices and suicide among farmers of the sundarban region in India. Food Nutr Bull 28:S381–S391
Christiansen SC, Schatz M, Yang S-J et al (2016) Hypertension and asthma: a comorbid relationship. J Allergy Clin Immunol Pract 4:76–81. https://doi.org/10.1016/j.jaip.2015.07.009
Cocciadiferro L, Miceli V, Granata OM, Carruba G (2016) Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells. J Steroid Biochem Mol Biol 172:222–230. https://doi.org/10.1016/j.jsbmb.2016.05.023
Cohen PG (2001) Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypotheses 56:702–708. https://doi.org/10.1054/mehy.2000.1169
Colle D, Farina M, Ceccatelli S, Raciti M (2018) Paraquat and maneb exposure alters rat neural stem cell proliferation by inducing oxidative stress: new insights on pesticide-induced neurodevelopmental toxicity. Neurotox Res 34:1–14
Colović MB, Krstić DZ, Lazarević-Pašti TD et al (2013) Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11:315–335. https://doi.org/10.2174/1570159X11311030006
Costa LG, Giordano G, Guizzetti M, Vitalone A (2008) Neurotoxicity of pesticides: a brief review. Front Biosci 13:1240–1249. https://doi.org/10.2741/2758
Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860–867. https://doi.org/10.1038/nature01322
Crisan D, Carr J (2000) Angiotensin I-converting enzyme: genotype and disease associations. J Mol Diagn 2:105–115. https://doi.org/10.1016/S1525-1578(10)60624-1
Crosnoe-Shipley LE, Elkelany OO, Rahnema CD, Kim ED (2015) Treatment of hypogonadotropic male hypogonadism: case-based scenarios. World J Nephrol 4:245–253. https://doi.org/10.5527/wjn.v4.i2.245
Damalas C, Koutroubas S (2017) Farmers’ training on pesticide use is associated with elevated safety behavior. Toxics 5:19. https://doi.org/10.3390/toxics5030019
Demura M, Martin RM, Shozu M, Sebastian S, Takayama K, Hsu WT, Schultz RA, Neely K, Bryant M, Mendonca BB, Hanaki K, Kanzaki S, Rhoads DB, Misra M, Bulun SE (2007) Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene. Hum Mol Genet 16:2529–2541. https://doi.org/10.1093/hmg/ddm145
Denkyirah EK, Okoffo ED, Adu DT, Aziz AA, Ofori A, Denkyirah EK (2016) Modeling Ghanaian cocoa farmers’ decision to use pesticide and frequency of application: the case of Brong Ahafo Region. Springerplus 5. https://doi.org/10.1186/s40064-016-2779-z
Diamanti-Kandarakis E, Bourguignon J-P, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC (2009) Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30:293–342. https://doi.org/10.1210/er.2009-0002
Do DC, Zhao Y, Gao P (2016) Cockroach allergen exposure and risk of asthma. Allergy 71:463–474. https://doi.org/10.1111/all.12827
Dongre AR, Deshmukh PR (2012) Farmers’ suicides in the Vidarbha region of Maharashtra, India: a qualitative exploration of their causes. J Inj Violence Res 4:2–6. https://doi.org/10.5249/jivr.v4i1.68
Drenjančević-Perić I, Jelaković B, Lombard JH, Kunert MP, Kibel A, Gros M (2011) High-salt diet and hypertension: focus on the renin-angiotensin system. Kidney Blood Press Res 34:1–11. https://doi.org/10.1159/000320387
Eddleston M, Buckley NA, Eyer P, Dawson AH (2008) Management of acute organophosphorus pesticide poisoning. Lancet (London, England) 371:597–607. https://doi.org/10.1016/S0140-6736(07)61202-1
Egbuta C, Lo J, Ghosh D (2014) Mechanism of inhibition of estrogen biosynthesis by azole fungicides. Endocrinology 155:4622–4628. https://doi.org/10.1210/en.2014-1561
Engel LS (2005) Pesticide use and breast cancer risk among farmers’ wives in the agricultural health study. Am J Epidemiol 161:121–135. https://doi.org/10.1093/aje/kwi022
Faglia G, Arosio M, Porretti S (2000) Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up? J Endocrinol Investig 23:721–723. https://doi.org/10.1007/BF03345059
Fommei E, Turci R, Ripoli A, Balzan S, Bianchi F, Morelli L, Coi A (2017) Evidence for persistent organochlorine pollutants in the human adrenal cortex. J Appl Toxicol 37:1091–1097. https://doi.org/10.1002/jat.3460
Gallegos CE, Baier CJ, Bartos M, Bras C, Domínguez S, Mónaco N, Gumilar F, Giménez MS, Minetti A (2018) Perinatal glyphosate-based herbicide exposure in rats alters brain antioxidant status, glutamate and acetylcholine metabolism and affects recognition memory. Neurotox Res 34:363–374. https://doi.org/10.1007/s12640-018-9894-2
García-Fernández R, Perbandt M, Rehders D, Ziegelmüller P, Piganeau N, Hahn U, Betzel C, Chávez MÁ, Redecke L (2015) Three-dimensional structure of a Kunitz-type inhibitor in complex with an elastase-like enzyme. J Biol Chem 290:14154–14165. https://doi.org/10.1074/jbc.M115.647586
Gasteiger E, Gattiker A, Hoogland C et al (2003) ExPASy: the proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 31:3784–3788. https://doi.org/10.1093/nar/gkg563
Gessl A, Lemmens-Gruber R, Kautzky-Willer A (2012) Thyroid disorders. Handb Exp Pharmacol:361–386. https://doi.org/10.1007/978-3-642-30726-3_17
Gewin V (2008) Pesticide suspected in bee deaths banned. Front Ecol Environ 6:294
Giácoman-Vallejos G, Lizarraga-Castro I, Ponce-Caballero C, González-Sánchez A, Hernández-Núñez E (2018) Presence of DDT and lindane in a karstic groundwater aquifer in Yucatan, Mexico. Groundw Monit Remediat 38:68–78. https://doi.org/10.1111/gwmr.12267
Gohara DW, Di Cera E (2011) Allostery in trypsin-like proteases suggests new therapeutic strategies. Trends Biotechnol 29:577–585. https://doi.org/10.1016/j.tibtech.2011.06.001
Goldner WS, Sandler DP, Yu F, Hoppin JA, Kamel F, LeVan TD (2010) Pesticide use and thyroid disease among women in the Agricultural Health Study. Am J Epidemiol 171:455–464. https://doi.org/10.1093/aje/kwp404
Goldner WS, Sandler DP, Yu F, Shostrom V, Hoppin JA, Kamel F, LeVan TD (2013) Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. J Occup Environ Med 55:1171–1178. https://doi.org/10.1097/JOM.0b013e31829b290b
Gonzales PH, Mezzomo LC, Ferreira NP, Roehe AV, Kohek MBF, Oliveira MC (2015) Aromatase P450 expression in human pituitary adenomas. Neuropathology 35:16–23. https://doi.org/10.1111/neup.12145
Gupta RC, Sachana M, Mukherjee IM, et al (2018) Organophosphates and carbamates. In: Veterinary toxicology: basic and clinical principles, Third edn. Pp 495–508. https://doi.org/10.1371/journal.pgen.1007751
Hefetz-Sela S, Scherer PE (2013) Adipocytes: impact on tumor growth and potential sites for therapeutic intervention. Pharmacol Ther 138:197–210. https://doi.org/10.1016/j.pharmthera.2013.01.008
Ho S-M (2003) Estrogen, progesterone and epithelial ovarian cancer. Reprod Biol Endocrinol 1:73. https://doi.org/10.1186/1477-7827-1-73
Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15:279–290. https://doi.org/10.1007/s10911-010-9187-8
Hovnanian A (2013) Netherton syndrome: skin inflammation and allergy by loss of protease inhibition. Cell Tissue Res 351:289–300. https://doi.org/10.1007/s00441-013-1558-1
Huang G, London J (2012) Mapping cumulative environmental effects, social vulnerability, and health in the San Joaquin Valley, California. Am J Public Health 102:830–832. https://doi.org/10.2105/AJPH.2011.300466
Hwang H, Zhang J, Chung KA et al (2010) Glycoproteomics in neurodegenerative diseases. Mass Spectrom Rev 29:79–125. https://doi.org/10.1002/mas.20221
Iravanian S, Dudley SC (2008) The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias. Heart Rhythm 5:S12–S17. https://doi.org/10.1016/j.hrthm.2008.02.025
Izawa M, Inoue M, Osaki M, Ito H, Harada T, Terakawa N, Ikeguchi M (2008) Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer. Gastric Cancer 11:103–110. https://doi.org/10.1007/s10120-008-0463-x
Jallow MFA, Awadh DG, Albaho MS et al (2017) Pesticide knowledge and safety practices among farm workers in Kuwait: results of a survey. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph14040340
Jenny L, Ajjan R, King R, Thiel S, Schroeder V (2015) Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control. Clin Exp Immunol 180:227–232. https://doi.org/10.1111/cei.12574
Jiang X (2014) Harnessing the immune system for the treatment of breast cancer. J Zhejiang Univ Sci B 15:1–15. https://doi.org/10.1631/jzus.B1300264
Jirásková-Vaníčková J, Ettrich R, Vorlová B et al (2011) Inhibition of human serine racemase, an emerging target for medicinal chemistry. Curr Drug Targets 12:1037–1055. https://doi.org/10.2174/138945011795677755
Kennedy J, King L (2014) The political economy of farmers’ suicides in India: indebted cash-crop farmers with marginal landholdings explain state-level variation in suicide rates. Glob Health 10:16. https://doi.org/10.1186/1744-8603-10-16
Kesavachandran CN, Fareed M, Pathak MK, et al (2009) Adverse health effects of pesticides in agrarian populations of developing countries. Rev Environ Contam Toxicol 200:33–52
Khush GS (2001) Green revolution: the way forward. Nat Rev Genet 2:815–822. https://doi.org/10.1038/35093585
Landgren O, Kyle RA, Hoppin JA, Beane Freeman LE, Cerhan JR, Katzmann JA, Rajkumar SV, Alavanja MC (2009) Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study. Blood 113:6386–6391. https://doi.org/10.1182/blood-2009-02-203471
Levitt T (2011) The film that stood up to banana giant {D}ole over pesticide poisoning (and won). Ecologist [online]
Li W-G, Xu T-L (2015) Acid-sensing ion channels: a novel therapeutic target for pain and anxiety. Curr Pharm Des 21:885–894
Li Q, Kobayashi M, Kawada T (2015) Carbamate pesticide-induced apoptosis in human T lymphocytes. Int J Environ Res Public Health 12:3633–3645. https://doi.org/10.3390/ijerph120403633
Li M-H, Leng T-D, Feng X-C, Yang T, Simon RP, Xiong ZG (2016) Modulation of acid-sensing Ion channel 1a by intracellular pH and its role in ischemic stroke. J Biol Chem 291:18370–18383. https://doi.org/10.1074/jbc.M115.713636
Lionetto MG, Caricato R, Calisi A, Giordano ME, Schettino T (2013) Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives. Biomed Res Int 2013:321213–321218. https://doi.org/10.1155/2013/321213
Marrs TC, Rice P, Vale JA (2006) The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 25:297–323. https://doi.org/10.2165/00139709-200625040-00009
Mathew P, Jose A, Alex RG, Mohan VR (2015) Chronic pesticide exposure: health effects among pesticide sprayers in Southern India. Indian J Occup Environ Med 19:95–101. https://doi.org/10.4103/0019-5278.165334
Meany DL, Chan DW (2011) Aberrant glycosylation associated with enzymes as cancer biomarkers. Clin Proteomics 8:7. https://doi.org/10.1186/1559-0275-8-7
Mehedintu C, Plotogea MN, Ionescu S, Antonovici M (2014) Endometriosis still a challenge. J Med Life 7:349–357
Metwalley KA, Farghaly HS (2013) Aromatase excess syndrome presenting with prepubertal gynecomastia in an Egyptian child with type 1 neurofibromatosis. Indian J Hum Genet 19:472–474. https://doi.org/10.4103/0971-6866.124379
Mohanty MK, Behera BK, Jena SK, Srikanth S, Mogane C, Samal S, Behera AA (2013) Knowledge attitude and practice of pesticide use among agricultural workers in Puducherry, South India. J Forensic Legal Med 20:1028–1031. https://doi.org/10.1016/j.jflm.2013.09.030
Naidoo S, London L, Burdorf A, Naidoo R, Kromhout H (2011) Spontaneous miscarriages and infant deaths among female farmers in rural South Africa. Scand J Work Environ Health 37:227–236. https://doi.org/10.5271/sjweh.3133
Navar LG (2014) Physiology: hemodynamics, endothelial function, renin-angiotensin-aldosterone system, sympathetic nervous system. J Am Soc Hypertens 8:519–524. https://doi.org/10.1016/j.jash.2014.05.014
Neupane D, Jørs E, Brandt L (2014) Pesticide use, erythrocyte acetylcholinesterase level and self-reported acute intoxication symptoms among vegetable farmers in Nepal: a cross-sectional study. Environ Health 13:98. https://doi.org/10.1186/1476-069X-13-98
Noris M, Remuzzi G (2013) Overview of complement activation and regulation. Semin Nephrol 33:479–492. https://doi.org/10.1016/j.semnephrol.2013.08.001
Patel S (2017a) A critical review on serine protease: key immune manipulator and pathology mediator. Allergol Immunopathol (Madr) 45:579–591. https://doi.org/10.1016/j.aller.2016.10.011
Patel S (2017b) Inflammasomes, the cardinal pathology mediators are activated by pathogens, allergens and mutagens: a critical review with focus on NLRP3. Biomed Pharmacother 92:819–825. https://doi.org/10.1016/j.biopha.2017.05.126
Patel S (2017c) Stressor-driven extracellular acidosis as tumor inducer via aberrant enzyme activation: a review on the mechanisms and possible prophylaxis. Gene 626:209–214. https://doi.org/10.1016/j.gene.2017.05.043
Patel S (2017d) Disruption of aromatase homeostasis as the cause of a multiplicity of ailments: a comprehensive review. J Steroid Biochem Mol Biol 168:19–25. https://doi.org/10.1016/j.jsbmb.2017.01.009
Patel S (2018) Breast cancer: lesser-known facets and hypotheses. Biomed Pharmacother 98:499–506. https://doi.org/10.1016/J.BIOPHA.2017.12.087
Patel S, Akhtar N (2017) Antimicrobial peptides (AMPs): the quintessential “offense and defense” molecules are more than antimicrobials. Biomed Pharmacother 95:1276–1283. https://doi.org/10.1016/j.biopha.2017.09.042
Patel S, Homaei A, Raju AB, Meher BR (2018) Estrogen: the necessary evil for human health, and ways to tame it. Biomed Pharmacother 102:403–411. https://doi.org/10.1016/j.biopha.2018.03.078
Pathak-Gandhi N, Vaidya ADB (2016) Management of Parkinson’s disease in Ayurveda: medicinal plants and adjuvant measures. J Ethnopharmacol 197:46–51. https://doi.org/10.1016/j.jep.2016.08.020
Pazaiti A, Fentiman IS (2011) Basal phenotype breast cancer: implications for treatment and prognosis. Women's Health (Lond Engl) 7:181–202. https://doi.org/10.2217/whe.11.5
Rajamäki K, Nordström T, Nurmi K, Åkerman KEO, Kovanen PT, Öörni K, Eklund KK (2013) Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome. J Biol Chem 288:13410–13419. https://doi.org/10.1074/jbc.M112.426254
Rastogi S, Tripathi S, Ravishanker D (2010) A study of neurologic symptoms on exposure to organophosphate pesticides in the children of agricultural workers. Indian J Occup Environ Med 14:54. https://doi.org/10.4103/0019-5278.72242
Reeve A, Simcox E, Turnbull D (2014) Ageing and Parkinson’s disease: why is advancing age the biggest risk factor? Ageing Res Rev 14:19–30. https://doi.org/10.1016/j.arr.2014.01.004
Rendón von Osten J, Epomex C, Tinoco-Ojanguren R et al (2004) Effect of pesticide exposure on acetylcholinesterase activity in subsistence farmers from Campeche, Mexico. Arch Environ Health 59:418–425. https://doi.org/10.3200/AEOH.59.8.418-425
Richard SA, Frank EA, D’Souza CJM (2013) Correlation between cholinesterase and paraoxonase 1 activities:case series of pesticide poisoning subjects. Bioimpacts 3:119–122. https://doi.org/10.5681/bi.2013.024
Richardson JR, Roy A, Shalat SL, von Stein RT, Hossain MM, Buckley B, Gearing M, Levey AI, German DC (2014) Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol 71:284–290. https://doi.org/10.1001/jamaneurol.2013.6030
Sands JM, Layton HE (2009) The physiology of urinary concentration: an update. Semin Nephrol 29:178–195. https://doi.org/10.1016/j.semnephrol.2009.03.008
Santin AP, Furlanetto TW (2011) Role of estrogen in thyroid function and growth regulation. J Thyroid Res 2011:875125–875127. https://doi.org/10.4061/2011/875125
Schwalfenberg GK (2012) The alkaline diet: is there evidence that an alkaline pH diet benefits health? J Environ Public Health 2012:727630–727637. https://doi.org/10.1155/2012/727630
Schwartz NA, von Glascoe CA, Torres V, Ramos L, Soria-Delgado C (2015) "Where they (live, work and) spray": pesticide exposure, childhood asthma and environmental justice among Mexican-American farmworkers. Health Place 32:83–92. https://doi.org/10.1016/j.healthplace.2014.12.016
Shakeel MK, George PS, Jose J et al (2010) Pesticides and breast cancer risk: a comparison between developed and developing countries. Asian Pac J Cancer Prev 11:173–180
Silman I, Sussman JL (2008) Acetylcholinesterase: how is structure related to function? Chem Biol Interact 175:3–10. https://doi.org/10.1016/j.cbi.2008.05.035
Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C, Jones M (2002) Aromatase--a brief overview. Annu Rev Physiol 64:93–127. https://doi.org/10.1146/annurev.physiol.64.081601.142703
Sirmans SM, Pate KA (2013) Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 6:1–13. https://doi.org/10.2147/CLEP.S37559
Soh UJK, Dores MR, Chen B, Trejo J (2010) Signal transduction by protease-activated receptors. Br J Pharmacol 160:191–203. https://doi.org/10.1111/j.1476-5381.2010.00705.x
Strelitz J, Engel LS, Keifer MC (2014) Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers. Occup Environ Med 71:842–847. https://doi.org/10.1136/oemed-2014-102315
Sur D, Yap SMS, Demayo CG (2015) Advances in environmental biology. Adv Environ Biol 9:134–142. https://doi.org/10.3390/bs5030384
Taetzsch T, Block ML (2013) Pesticides, microglial NOX2, and Parkinson’s disease. J Biochem Mol Toxicol 27:137–149. https://doi.org/10.1002/jbt.21464
Taghavian F, Vaezi G, Abdollahi M, Malekirad AA (2016) Comparative toxicological study between exposed and non-exposed farmers to organophosphorus pesticides. Cell J 18:89–96
Tammen SA, Friso S, Choi S-W (2013) Epigenetics: the link between nature and nurture. Mol Asp Med 34:753–764. https://doi.org/10.1016/j.mam.2012.07.018
Toe AM, Ouedraogo M, Ouedraogo R, Ilboudo S, Guissou PI (2013) Pilot study on agricultural pesticide poisoning in Burkina Faso. Interdiscip Toxicol 6:185–191. https://doi.org/10.2478/intox-2013-0027
Trivanović D, Jauković A, Krstić J, Nikolić S, Okić Djordjević I, Kukolj T, Obradović H, Mojsilović S, Ilić V, Santibanez JF, Bugarski D (2016) Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1. IUBMB Life 68:190–200. https://doi.org/10.1002/iub.1473
Verdecchia P, Angeli F, Mazzotta G et al (2008) The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag 4:971–981
Verma MK, Miki Y, Abe K, Nagasaki S, Niikawa H, Suzuki S, Kondo T, Sasano H (2012) Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome. Life Sci 91:800–808. https://doi.org/10.1016/j.lfs.2012.08.029
Vicente da MGH, Smith KM (2014) Syntheses and functionalizations of porphyrin macrocycles. Curr Org Synth 11:3–28. https://doi.org/10.2174/15701794113106660083
Wang X-J, Cao Q, Zhang Y, Su X-D (2015) Activation and regulation of caspase-6 and its role in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 55:553–572. https://doi.org/10.1146/annurev-pharmtox-010814-124414
Watabe M, Nakaki T (2007) Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther 323:499–507. https://doi.org/10.1124/jpet.107.127597.and
Wemmie JA, Taugher RJ, Kreple CJ (2013) Acid-sensing ion channels in pain and disease. Nat Rev Neurosci 14:461–471. https://doi.org/10.1038/nrn3529
Williams CB, Yeh ES, Soloff AC et al (2016) Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy. Breast Cancer 2:15025. https://doi.org/10.1038/npjbcancer.2015.25
Wojtukiewicz MZ, Hempel D, Sierko E, Tucker SC, Honn KV (2015) Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis. Cancer Metastasis Rev 34:775–796. https://doi.org/10.1007/s10555-015-9599-4
Wong AKF, Howie J, Petrie JR, Lang CC (2009) AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) 116:607–620. https://doi.org/10.1042/CS20080066
Yatabe J, Yoneda M, Yatabe MS, Watanabe T, Felder RA, Jose PA, Sanada H (2011) Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology 152:1582–1588. https://doi.org/10.1210/en.2010-1070
Zarn JA, Brüschweiler BJ, Schlatter JR (2003a) Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14α-demethylase and aromatase. Environ Health Perspect 111:255–261
Zarn JA, Brüschweiler BJ, Schlatter JR (2003b) Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase. Environ Health Perspect 111:255–261
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Patel, S., Sangeeta, S. Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public. Environ Sci Pollut Res 26, 91–100 (2019). https://doi.org/10.1007/s11356-018-3642-2
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DOI: https://doi.org/10.1007/s11356-018-3642-2