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Bone of Contention: Helicobacter pylori and Osteoporosis—Is There an Association?

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Abstract

Helicobacter pylori (H. pylori) infection is a common disease that can cause chronic gastritis, peptic ulcers, and gastric cancer. Nevertheless, due to its ability to elicit a systemic inflammatory response, it has also been related to several extra-gastric manifestations including endocrine disorders, such as autoimmune thyroid diseases, diabetes mellitus, dyslipidemia, and obesity. H. pylori infection has also been linked to osteoporosis, although currently available data are equivocal. This brief review will focus on the possible association between H. pylori infection and osteoporosis, a silent disease characterized by decreased bone mass that can increase the occurrence of fractures, disability, and mortality.

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Author notes

  1. Konstantinos Papamichael and Garyfallia Papaioannou have contributed equally to this work.

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA, 02215, USA

    Konstantinos Papamichael & Adam S. Cheifetz

  2. North Florida Regional Medical Center, Internal Medicine Residency Program, College of Medicine, University of Central Florida, Gainesville, FL, USA

    Garyfallia Papaioannou

  3. Department of Endocrinology, Harvard Vanguard Medical Associates/Atrius Health, Chestnut Hill, MA, USA

    Marcy A. Cheifetz

Authors
  1. Konstantinos Papamichael
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  2. Garyfallia Papaioannou
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  3. Marcy A. Cheifetz
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  4. Adam S. Cheifetz
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Contributions

K.P. and G.P. wrote the manuscript; A.S.C. and M.A.C. critically revised the manuscript. All the authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Konstantinos Papamichael.

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Conflict of interest

A.S.C has received consulting fees from Abbvie, Janssen, Takeda Pfizer, Amag, and Arena and research support from Miraca. K.P. has received a lecture fee from Mitsubishi Tanabe Pharma. The remaining authors declare no conflict of interest.

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Papamichael, K., Papaioannou, G., Cheifetz, M.A. et al. Bone of Contention: Helicobacter pylori and Osteoporosis—Is There an Association?. Dig Dis Sci 64, 2736–2739 (2019). https://doi.org/10.1007/s10620-019-05775-4

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  • DOI: https://doi.org/10.1007/s10620-019-05775-4

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