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Changes in Oxidant and Antioxidant Status of Females with Experimental Gestosis under the Effect of GABA Derivatives

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Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition of SOD and glutathione peroxidase in the brain, liver, and uterus of animals with gestosis. Citrocard and saliphene (GABA derivatives) inhibited LPO (reduced MDA concentrations in the studied organs) and activated antioxidant enzymes in experimental gestosis.

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Authors and Affiliations

  1. Department of Pharmacology and Biopharmacy, Faculty for Advanced Medical Training, Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia

    I. N. Tyurenkov, V. N. Perfilova, T. A. Popova, L. B. Ivanova, I. I. Prokofiev, O. V. Gulyaeva & L. I. Stepa

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  1. I. N. Tyurenkov
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  2. V. N. Perfilova
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  3. T. A. Popova
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  4. L. B. Ivanova
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  5. I. I. Prokofiev
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  6. O. V. Gulyaeva
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  7. L. I. Stepa
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Corresponding author

Correspondence to V. N. Perfilova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 340–343, March, 2013

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Tyurenkov, I.N., Perfilova, V.N., Popova, T.A. et al. Changes in Oxidant and Antioxidant Status of Females with Experimental Gestosis under the Effect of GABA Derivatives. Bull Exp Biol Med 155, 363–365 (2013). https://doi.org/10.1007/s10517-013-2154-9

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  • DOI: https://doi.org/10.1007/s10517-013-2154-9

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