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Evaluation of Effects of Histochrome and Mexidol on Structural and Functional Characteristics of the Brain in Senescence-Accelerated OXYS Rats by Magnetic Resonance Imaging

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The effects of histochrome and mexidol on the morphology and function of the brain and behavior were studied in senescence-accelerated OXYS and Wistar rats. MRI showed that signs of neurodegenerative changes were present in OXYS rats at the age of 3 months and were pronounced at the age of 12 months. Histochrome (1 mg/kg, 5 days) more effectively than mexidol (4 mg/kg, 7 days) reduced anxiety and increased exploratory activity of 1-yearold OXYS rats. Both drugs improved the morphology and function of the brain. Their effects consisting in correction of diffuse changes in the white matter and reduction of edema were comparable; in addition, histochrome reduced the intensity of demyelinization processes.

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Authors and Affiliations

  1. Pacific Institute of Organic Biochemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia

    I. G. Agafonova & N. P. Mischenko

  2. State Medical University, Vladivostok, Russia

    V. N. Kotel’nikov

  3. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. G. Kolosova

Authors
  1. I. G. Agafonova
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  2. V. N. Kotel’nikov
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  3. N. P. Mischenko
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  4. N. G. Kolosova
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Corresponding author

Correspondence to I. G. Agafonova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 12, pp. 686-690, December, 2010

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Agafonova, I.G., Kotel’nikov, V.N., Mischenko, N.P. et al. Evaluation of Effects of Histochrome and Mexidol on Structural and Functional Characteristics of the Brain in Senescence-Accelerated OXYS Rats by Magnetic Resonance Imaging. Bull Exp Biol Med 150, 739–743 (2011). https://doi.org/10.1007/s10517-011-1238-7

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  • DOI: https://doi.org/10.1007/s10517-011-1238-7

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