Abstract
Background
Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic–pituitary–adrenal (HPA) axis suppression, has limited their use.
Objective
This article reviews the topical steroid prednicarbate through its mechanism of action, clinical efficacy, and adverse events profile.
Methods
Published literature containing the word “prednicarbate” was examined and summarized.
Results
Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis. It has a favorable benefit–risk ratio, low skin atrophy potential, and high anti-inflammatory action.
Conclusion
These characteristics make prednicarbate an ideal alternative agent for children, elderly patients, and those who require long-term intermittent treatment.
Sommaire
Antécédents
Les stéroïdes topiques représentent un choix populaire dans le traitement de divers troubles cutanés. Toutefois, la possibilité d’événements indésirables locaux et systémiques, tels que 1’atrophie cutanée et la suppression de 1’axe hypothalamo-hypophyso-surrénalien, ont limité leur usage.
Objectif
Cette étude souligne le mécanisme d’action, 1’efficacité clinique et le profil des événements indésirables du prednicarbate, un stéroïde topique.
Méthode
Les articles spécialisés publiés contenant le terme ‹prednicarbate› ont été revus et résumés.
Résultats
Le prednicarbate est un dérivé du prednisone, non halogéné et double ester, utilisé dans le traitement des manifestations inflammatoires et pruritiques des dermatoses qui réagissent aux corticostéroïdes, telles que les dermatites atopiques. Le prednicarbate présente un rapport avantage-risque favorable, avec un faible potentiel d’atrophie cutanée et une action anti-inflammatoire puissante.
Conclusion
Grâce à ces caractéristiques, le prednicarbate est un agent alternatif idéal pour les enfants, les personnes âgées et les patients nécessitant un traitement intermittent de longue durée.
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The work was supported in part by Dermik Laboratories.
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Gupta, A.K., Chow, M. Prednicarbate (Dermatop®): Profile of a Corticosteroid. J Cutan Med Surg 8, 244–249 (2004). https://doi.org/10.1007/s10227-004-0120-x
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DOI: https://doi.org/10.1007/s10227-004-0120-x