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The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis

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Abstract

The aim of this paper is to compare the effect of nebulized magnesium sulfate to nebulized salbutamol and salbutamol/magnesium sulfate on successful discharge from the emergency department. A total of 56 infants were included in this double-blinded, prospective study. Infants were grouped according to the nebulized treatment they received: group 1—salbutamol/normal saline, group 2—magnesium sulfate and normal saline, and group 3—salbutamol plus magnesium sulfate. Heart beat, bronchiolitis, clinical severity scores (CSS), and oxygen saturation of the patients were determined before and after nebulization (0, 1, 4 h). The patients were monitored for adverse reactions. Post-treatment mean CSS results were significantly lower than pre-treatment scores in all groups at 4 h with no significant difference within groups. CSS scores were lower in the salbutamol/magnesium sulfate group when compared with the magnesium sulfate and salbutamol groups (3.4 (2.4–4.3), 4.7 (3.8–5.7), 4.0 (3.2–4.3)). CSS were significantly lower than those from the magnesium sulfate group. Conclusion: Nebulized magnesium sulfate plus salbutamol may have additive effects for improving the short-term CSS.

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Abbreviations

CSS:

Clinical severity scores

SaO2 :

Oxygen saturation

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Conflict of interest

None of the authors have conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Pulmonology, Erciyes University Faculty of Medicine, Pediatric Pulmonology Unit, Kayseri, 38000, Turkey

    Mehmet Kose

  2. Department of Pediatric Emergency Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Mehmet Adnan Ozturk

  3. Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Hakan Poyrazoğlu, Tuba Elmas, Duygu Ekinci, Filiz Tubas, Tuba Kurt & Mehmet Akif Goktas

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  1. Mehmet Kose
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  2. Mehmet Adnan Ozturk
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  3. Hakan Poyrazoğlu
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  4. Tuba Elmas
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  5. Duygu Ekinci
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  6. Filiz Tubas
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  7. Tuba Kurt
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  8. Mehmet Akif Goktas
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Correspondence to Mehmet Kose.

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Communicated by Peter de Winter

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Kose, M., Ozturk, M.A., Poyrazoğlu, H. et al. The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis. Eur J Pediatr 173, 1157–1160 (2014). https://doi.org/10.1007/s00431-014-2309-3

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  • DOI: https://doi.org/10.1007/s00431-014-2309-3

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