Abstract
Objective
This article reviews the clinical results that can be obtained after repair of a traumatic peripheral nerve injury in the pediatric population.
Methods
A systematic review of the published literature has been made.
Results
Functional outcome after major nerve injuries is sometimes disappointing in adults. However, children have been reported to experience much better functional results after nerve repair than adults. Moreover, recovery generally is faster in children. The superior capacity of children’s central nervous system to adapt to external or internal environmental changes (neural plasticity) and the shorter recovery distance from the axon repair site to the target muscle are claimed to be crucial determinants of their favorable outcomes. Moreover, even in the pediatric population, it has been demonstrated that functional results are better the younger the patient is, including better clinical results in those injured in early childhood (< 6 years old) than in those injured in adolescence. Other favorable prognostic factors include the type of nerve injury (with complete transections doing less well than crush injuries) and the timing of surgery (with better outcomes after early repairs).
Conclusions
All efforts should be done to repair in a timely and adequate fashion traumatic peripheral nerve injuries in children, as the results are good.
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References
Birch R, Achan P (2000) Peripheral nerve repairs and their results in children. Hand Clin 16:579–595
Waters PM, Bae DS (2012) Traumatic peripheral nerve injuries. In: Pediatric hand and upper limb surgery: a practical guide. Springhouse Publishing Co, U.S.
Sunderland S (1951) A classification of peripheral nerve injuries producing loss of function. Brain J Neurol 74:491–516
Galanakos SP, Zoubos AB, Ignatiadis I, Papakostas I, Gerostathopoulos NE, Soucacos PN (2011) Repair of complete nerve lacerations at the forearm: an outcome study using Rosén-Lundborg protocol. Microsurgery 31:253–262. https://doi.org/10.1002/micr.20845
Chemnitz A, Björkman A, Dahlin LB, Rosén B (2013) Functional outcome thirty years after median and ulnar nerve repair in childhood and adolescence. J Bone Joint Surg Am 95:329–337. https://doi.org/10.2106/JBJS.L.00074
Tajima T, Imai H (1989) Results of median nerve repair in children. Microsurgery 10:145–146
Barrios C, de Pablos J (1991) Surgical management of nerve injuries of the upper extremity in children: a 15-year survey. J Pediatr Orthop 11:641–645
Lundborg G, Rosén B (2001) Sensory relearning after nerve repair. Lancet Lond Engl 358:809–810. https://doi.org/10.1016/S0140-6736(01)06001-9
Atherton DD, Taherzadeh O, Elliot D, Anand P (2008) Age-dependent development of chronic neuropathic pain, allodynia and sensory recovery after upper limb nerve injury in children. J Hand Surg Eur Vol 33:186–191. https://doi.org/10.1177/1753193408087029
Stevenson JH, Zuker RM (1986) Upper limb motor and sensory recovery after multiple proximal nerve injury in children: a long term review in five patients. Br J Plast Surg 39:109–113
Felice KJ, Royden Jones H (1996) Pediatric ulnar mononeuropathy: report of 21 electromyography-documented cases and review of the literature. J Child Neurol 11:116–120. https://doi.org/10.1177/088307389601100211
Mc Donald CM (2015) Electrodiagnosis in pediatrics. In: Alexander MA, Matthews DJ (eds) Pediatric rehabilitation. principles and practice, Fifth edn. Demos Medical Publishing, New York, pp 113–152
Birch R (2011) Surgical disorders of peripheral nerves, 2nd edn. Springer-Verlag, London
Woo A, Bakri K, Moran SL (2015) Management of ulnar nerve injuries. J Hand Surg 40:173–181. https://doi.org/10.1016/j.jhsa.2014.04.038
Ruijs ACJ, Jaquet J-B, Kalmijn S, Giele H, Hovius SER (2005) Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast Reconstr Surg 116:484–494 discussion 495–496
Gaul JS (1982) Intrinsic motor recovery--a long-term study of ulnar nerve repair. J Hand Surg 7:502–508
Lundborg G, Rosén B, Dahlin L et al (2004) Tubular repair of the median or ulnar nerve in the human forearm: a 5-year follow-up. J Hand Surg Edinb Scotl 29:100–107. https://doi.org/10.1016/j.jhsb.2003.09.018
Strickland JW, Idler RS, DelSignore JL (1991) Ulnar nerve repair. In: Gelberman RH (ed) Operative nerve repair and reconstruction. JB Lippincott, Philadelphia, pp 425–436
Bolitho DG, Boustred M, Hudson DA, Hodgetts K (1999) Primary epineural repair of the ulnar nerve in children. J Hand Surg 24:16–20. https://doi.org/10.1053/jhsu.1999.jhsu25a0016
Sakellarides H (1962) A follow-up study of 172 peripheral nerve injuries in the upper extremity in civilians. J Bone Joint Surg Am 44-A:140–148
Berger A, Mailänder P (1991) Advances in peripheral nerve repair in emergency surgery of the hand. World J Surg 15:493–500
Escolar DM, Jones HR (1996) Pediatric radial mononeuropathies: a clinical and electromyographic study of sixteen children with review of the literature. Muscle Nerve 19:876–883. https://doi.org/10.1002/(SICI)1097-4598(199607)19:7<876::AID-MUS10>3.0.CO;2-H
Pollock FH, Drake D, Bovill EG, Day L, Trafton PG (1981) Treatment of radial neuropathy associated with fractures of the humerus. J Bone Joint Surg Am 63:239–243
Amillo S, Mora G (1999) Surgical management of neural injuries associated with elbow fractures in children. J Pediatr Orthop 19:573–577
Bertelli J, Soldado F, Ghizoni MF (2018) Outcomes of radial nerve grafting in children after distal humerus fracture. J Hand Surg. https://doi.org/10.1016/j.jhsa.2018.04.018
Shergill G, Bonney G, Munshi P, Birch R (2001) The radial and posterior interosseous nerves. Results of 260 repairs. J Bone Joint Surg (Br) 83:646–649
Jessing P (1975) Monteggia lesions and their complicating nerve damage. Acta Orthop Scand 46:601–609
Brown JM, Tung THH, Mackinnon SE (2010) Median to radial nerve transfer to restore wrist and finger extension: technical nuances. Neurosurgery 66:75–83; discussion 83. https://doi.org/10.1227/01.NEU.0000354364.13224.C8
Ustün ME, Ogün TC, Büyükmumcu M (2001) Neurotization as an alternative for restoring finger and wrist extension. J Neurosurg 94:795–798. https://doi.org/10.3171/jns.2001.94.5.0795
Jones HR (1986) Compressive neuropathy in childhood: a report of 14 cases. Muscle Nerve 9:720–723. https://doi.org/10.1002/mus.880090807
Trojaborg W (1976) Motor and sensory conduction in the musculocutaneous nerve. J Neurol Neurosurg Psychiatry 39:890–899
Osann E (1910) Beitrag zur Kenntnis der isolierten Lahmung des N. musculo-cutaneus. Dtsch Med Wochenschr 36:832–835
Sunderland S (1968) Nerves and nerve injuriese. Livingstone, Edinburgh, pp 358–396
Babal JC, Mehlman CT, Klein G (2010) Nerve injuries associated with pediatric supracondylar humeral fractures: a meta-analysis. J Pediatr Orthop 30:253–263. https://doi.org/10.1097/BPO.0b013e3181d213a6
Culp RW, Osterman AL, Davidson RS, Skirven T, Bora FW Jr (1990) Neural injuries associated with supracondylar fractures of the humerus in children. J Bone Joint Surg Am 72:1211–1215
Novak CB, Anastakis DJ, Beaton DE, Katz J (2009) Patient-reported outcome after peripheral nerve injury. J Hand Surg 34:281–287. https://doi.org/10.1016/j.jhsa.2008.11.017
Nath RK, Karicherla P, Mahmooduddin F (2010) Shoulder function and anatomy in complete obstetric brachial plexus palsy: long-term improvement after triangle tilt surgery. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg 26:1009–1019. https://doi.org/10.1007/s00381-010-1174-2
Koenigsberger MR, Moessinger AC (1977) Iatrogenic carpal tunnel syndrome in the newborn infant. J Pediatr 91:443–445
Spinner M, Schreiber SN (1969) Anterior interosseous-nerve paralysis as a complication of supracondylar fractures of the humerus in children. J Bone Joint Surg Am 51:1584–1590
Pape KE, Armstrong DL, Fitzhardinge PM (1978) Peripheral median nerve damage secondary to brachial arterial blood gas sampling. - PubMed - NCBI. J Pediatr 93:852–856
Drew SJ, Giddins GE, Birch R (1995) A slowly evolving brachial plexus injury following a proximal humeral fracture in a child. J Hand Surg Edinb Scotl 20:24–25
Berry H, Bril V (1982) Axillary nerve palsy following blunt trauma to the shoulder region: a clinical and electrophysiological review. J Neurol Neurosurg Psychiatry 45:1027–1032
Liveson JA (1984) Nerve lesions associated with shoulder dislocation; an electrodiagnostic study of 11 cases. J Neurol Neurosurg Psychiatry 47:742–744
al-Ghazal SK, McKiernan M, Khan K, McCann J (1994) Results of clinical assessment after primary digital nerve repair. J Hand Surg Edinb Scotl 19:255–257
Chaise F, Friol JP, Gaisne E (1993) Results of emergency repair of wounds of palmar collateral nerves of the fingers. Rev Chir Orthop Reparatrice Appar Mot 79:393–397
Efstathopoulos D, Gerostathopoulos N, Misitzis D, Bouchlis G, Anagnostou S, Daoutis NK (1995) Clinical assessment of primary digital nerve repair. Acta Orthop Scand Suppl 264:45–47
Sriram K, Sakthivel A (1981) Sciatic nerve palsy in the new born. Ann Acad Med Singap 10:472–475
Ouvrier RA, Shield L (1999) Focal lesions of peripheral nerves. In: Ouvrier RA, Mcleod JG, Pollard JD (eds) Peripheral neuropathy in childhood. MacKeith Press, London
Levin KH, Wilbourn AJ, Jones HR (1991) Childhood peroneal neuropathy from bone tumors. Pediatr Neurol 7:308–309
Jones HR, Felice KJ, Gross PT (1993) Pediatric peroneal mononeuropathy: a clinical and electromyographic study. Muscle Nerve 16:1167–1173. https://doi.org/10.1002/mus.880161105
Wang J-C, Chan R, Yang T-F (2014) Delayed onset of peroneal neuropathy after minor ankle torsion in a 9-year-old boy. J Child Neurol 29:843–845. https://doi.org/10.1177/0883073813477688
Hope EE, Bodensteiner JB, Thong N (1985) Neonatal lumbar plexus injury. Arch Neurol 42:94–95
Egel RT, Cueva JP, Adair RL (1995) Posttraumatic childhood lumbosacral plexus neuropathy. Pediatr Neurol 12:62–64
Chiou-Tan FY, Kemp K, Elfenbaum M et al (2001) Lumbosacral plexopathy in gunshot wounds and motor vehicle accidents: comparison of electrophysiologic findings. Am J Phys Med Rehabil 80:280–285 quiz 286–288
Makarov MR, Samchukov ML, Birch JG, Cherkashin AM, Sparagana SP, Delgado MR (2012) Somatosensory evoked potential monitoring of peripheral nerves during external fixation for limb lengthening and correction of deformity in children. J Bone Joint Surg (Br) 94:1421–1426. https://doi.org/10.1302/0301-620X.94B10.28913
Polo A, Zambito A, Aldegheri R, Tinazzi M, Rizzuto N (1999) Nerve conduction changes during lower limb lengthening. Somatosensory evoked potentials (SEPs) and F-wave results. Electromyogr Clin Neurophysiol 39:139–144
Polo A, Aldegheri R, Zambito A, Trivella G, Manganotti P, de Grandis D, Rizzuto N (1997) Lower-limb lengthening in short stature. An electrophysiological and clinical assessment of peripheral nerve function. J Bone Joint Surg (Br) 79:1014–1018
Marquez S, Turley JJ, Peters WJ (1993) Neuropathy in burn patients. Brain J Neurol 116(Pt 2):471–483
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Costales, J.R., Socolovsky, M., Sánchez Lázaro, J.A. et al. Peripheral nerve injuries in the pediatric population: a review of the literature. Part I: traumatic nerve injuries. Childs Nerv Syst 35, 29–35 (2019). https://doi.org/10.1007/s00381-018-3974-8
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DOI: https://doi.org/10.1007/s00381-018-3974-8