Skip to main content

Advertisement

SpringerLink
Log in

Hits and misses in research trends to monitor contaminants in foods

  • Review
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Monitoring of chemicals of toxicological concern in food is commonly needed for many purposes, which include (in part) food safety, regulatory enforcement, risk assessment, international food trade, label claims, environmental protection, industry needs, academic research, and consumer confidence. Chemicals of current concern include a variety of toxins, pesticides, veterinary drugs, growth promoters, environmental contaminants, toxic metals, allergens, endocrine disruptors, genetically modified organisms, melamine, acrylamide, furans, nitrosamines, food additives, packaging components, and miscellaneous other chemicals. In light of past crises, the potential harm from known or unknown chemicals not currently monitored are a source of additional concern by the food industry, regulators, scientists, and consumers. As global food trade has expanded and detection techniques have improved, chemical contaminant analysis of foods has also increased in importance and activity. This critical review article is aimed to highlight current trends in the literature, including neglected research needs, on the analysis of chemicals of toxicological concern in foods.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Hudson JA, Frewer LJ, Jones G, Brereton PA, Whittingham MJ, Stewart G. The agri-food chain and antimicrobial resistance: a review. Trends Food Sci Technol. 2017;69:131–47.

    Article  CAS  Google Scholar 

  2. World Trade Organization. International trade statistics 2015. www.wto.org/english/res_e/statis_e/its2015_e/its15_toc_e.htm. Accessed Feb 2018.

  3. US Central Intelligence Agency. The world factbook 2017. www.cia.gov/library/publications/the-world-factbook/. Accessed Feb 2018.

  4. Randall E. Food, risk and politics: scare, scandal and crisis - insights into the risk politics of food safety. Manchester: Manchester University Press; 2009. 272 pp

    Book  Google Scholar 

  5. De Brabander HF, Vanden Bussche J, Verbeke W, Vanhaecke L. The economics of residue analysis. Trends Anal Chem. 2011;30:1088–94.

    Article  CAS  Google Scholar 

  6. Clarivate Analytics. Web of science. clarivate.com/products/web-of-science. Accessed Feb 2018.

  7. US Food and Drug Administration. Contaminants and adulteration. www.fda.gov/Food/FoodborneIllnessContaminants. Accessed Feb 2018.

  8. Borchers A, Teuber SS, Keen CL, Gershwin ME. Food safety. Clin Rev Allergy Immunol. 2010;39:95–141.

    Article  CAS  PubMed  Google Scholar 

  9. Krska R, Becalski A, Braekevelt E, Koerner T, Cao XL, Dabeka R, et al. Challenges and trends in the determination of selected chemical contaminants and allergens in food. Anal Bioanal Chem. 2012;402:139–62.

    Article  CAS  PubMed  Google Scholar 

  10. Amelin VG, Lavrukhina OI. Food safety assurance using methods of chemical analysis. J Anal Chem. 2017;72:1–46.

    Article  CAS  Google Scholar 

  11. Purcaro G, Moret S, Conte LS. Overview on polycyclic aromatic hydrocarbons: occurrence, legislation and innovative determination in foods. Talanta. 2013;105:292–305.

    Article  CAS  PubMed  Google Scholar 

  12. Cruz R, Cunha SC, Marques A, Casal S. Polybrominated diphenyl ethers and metabolites—an analytical review on seafood occurrence. Trends Anal Chem. 2017;87:129–44.

    Article  CAS  Google Scholar 

  13. Pietron WJ, Malagocki P. Quantification of polybrominated diphenyl ethers (PBDEs) in food. A review. Talanta. 2017;167:411–27.

    Article  CAS  PubMed  Google Scholar 

  14. Fromme H, Becher G, Hilger B, Volkel W. Brominated flame retardants—exposure and risk assessment for the general population. Int J Hyg Environ Health. 2016;219:1–23.

    Article  CAS  PubMed  Google Scholar 

  15. Nicolas J, Hoogenboom RLAP, Hendricksen PJM, Bodero M, Bovee TFH, Rietjens IMCM, et al. Marine biotoxins and associated outbreaks following seafood consumption: prevention and surveillance in the 21st century. Global Food Secur Agric Policy Econ Environ. 2017;15:11–21.

    Article  Google Scholar 

  16. Rodriguez I, Vieytes MR, Alfonso A. Analytical challenges for regulated marine toxins. Detection methods. Curr Opin Food Sci. 2017;18:29–36.

    Article  Google Scholar 

  17. Gomes T, Albergamo A, Costa R, Mondello L, Dugo G. Potential use of proteomics in shellfish aquaculture: from assessment of environmental toxicity to evaluation of seafood quality and safety. Curr Org Chem. 2017;21:402–25.

    Article  CAS  Google Scholar 

  18. Biji KB, Ravishankar CN, Venkateswarlu R, Mohan CO, Gopal TKS. Biogenic amines in seafood: a review. J Food Sci Technol. 2016;53:2210–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Wright SL, Kelly FJ. Plastic and human health: a micro issue? Environ Sci Technol. 2017;51:6634–47.

    Article  CAS  PubMed  Google Scholar 

  20. Hahladakis JN, Velis CA, Weber R, Iacovidou E, Purnell P. An overview of chemical additives present in plastics: migration, release, fate and environmental impact during their use, disposal and recycling. J Hazard Mater. 2018;344:179–99.

    Article  CAS  PubMed  Google Scholar 

  21. Bouwmeester H, Hollman PCH, Peters RJB. Potential health impact of environmentally released micro- and nanoplastics in the human food production chain: experiences from nanotoxicology. Environ Sci Technol. 2015;49:8932–47.

    Article  CAS  PubMed  Google Scholar 

  22. Mattarozzi M, Suman M, Cascio C, Calestani D, Weigel S, Undas A, et al. Analytical approaches for the characterization and quantification of nanoparticles in food and beverages. Anal Bioanal Chem. 2017;409:63–80.

    Article  CAS  PubMed  Google Scholar 

  23. Pico Y, Alfarham A, Barcelo D. Analysis of emerging contaminants and nanomaterials in plant materials following uptake from soils. Trends Anal Chem. 2017;94:173–89.

    Article  CAS  Google Scholar 

  24. Guo HY, He LL, Xing BS. Applications of surface-enhanced Raman spectroscopy in the analysis of nanoparticles in the environment. Environ Sci-Nano. 2017;4:2093–107.

    Article  CAS  Google Scholar 

  25. Arulandhu AJ, van Dijk JP, Dobnik D, Holst-Jensen A, Shi JX, Zel J, et al. DNA enrichment approaches to identify unauthorized genetically modified organisms (GMOs). Anal Bioanal Chem. 2016;408:4575–93.

    Article  CAS  PubMed  Google Scholar 

  26. Lin CH, Pan TM. Perspectives on genetically modified crops and food detection. J Food Drug Anal. 2016;24:1–8.

    Article  PubMed  Google Scholar 

  27. Arugula MA, Zhang YY, Simonian AL. Biosensors as 21st century technology for detecting genetically modified organisms in food and feed. Anal Chem. 2014;86:119–29.

    Article  CAS  PubMed  Google Scholar 

  28. Alves RC, Barroso MF, Gonzalez-Garcia MB, Oliveira MBPP, Delerue-Matos C. New trends in food allergens detection: toward biosensing strategies. Crit Rev Food Sci Nutr. 2016;56:2304–19.

    Article  CAS  PubMed  Google Scholar 

  29. Prado M, Ortea I, Vial S, Rivas J, Calo-Mata P, Barros-Valazques J. Advanced DNA- and protein-based methods for detection and investigation of food allergens. Crit Rev Food Sci Nutr. 2016;56:2511–42.

    Article  CAS  PubMed  Google Scholar 

  30. Chiou JC, Leung AHH, Lee HW, Wong WT. Rapid testing methods for food contaminants and toxicants. J Integr Agric. 2015;14:2243–64.

    Article  CAS  Google Scholar 

  31. Crews C. The determination of N-nitrosamines in food. Qual Assur Safety Crops Foods. 2010;2:2–12.

    Article  CAS  Google Scholar 

  32. Iwaoka K. The current limits for radionuclides in food in Japan. Health Phys. 2016;111:417–8.

    Article  CAS  Google Scholar 

  33. Kolacinska K, Trojanowicz M. Application of flow analysis in determination of selected radionuclides. Talanta. 2014;125:131–45.

    Article  CAS  PubMed  Google Scholar 

  34. Maxwell SL, Culligan BK, Kelsey-Wall A, Shaw PJ. Rapid determination of actinides in emergency food samples. J Radioanal Nucl Chem. 2012;292:339–47.

    Article  CAS  Google Scholar 

  35. Iammarino M, Marino R, Albenzio M. How meaty? Detection and quantification of adulterants, foreign proteins and food additives in meat products. Int J Food Sci Technol. 2017;52:851–63.

    Article  CAS  Google Scholar 

  36. Maffini MV, Alger HM, Olson ED, Neltner TG. Looking back to look forward: a review of FDA's food additives safety assessment and recommendations for modernizing its program. Compr Rev Food Sci Food Saf. 2013;12:439–53.

    Article  Google Scholar 

  37. Sanchis Y, Yusa V, Coscolla C. Analytical strategies for organic food packaging contaminants. J Chromatogr A. 2017;1490:22–46.

    Article  CAS  PubMed  Google Scholar 

  38. Yang T, Huang HF, Zhu F, Lin QL, Zhang L, Liu JW. Recent progresses in nanobiosensing for food safety analysis. Sensors. 2016;16:1118.

    Article  CAS  Google Scholar 

  39. Mantovani A. Endocrine disrupters and the safety of food chains. Horm Res Paediatr. 2016;86:279–88.

    Article  CAS  PubMed  Google Scholar 

  40. Careghini A, Mastorgio AF, Saponaro S, Sezenna E. Bisphenol a, nonylphenols, benzophenones, and benzotriazoles in soils, groundwater, surface water, sediments, and food: a review. Environ Sci Pollut Res. 2015;22:5711–41.

    Article  CAS  Google Scholar 

  41. Harunarashid NZIH, Lim LH, Harunsani MH. Phthalate sample preparation methods and analysis in food and food packaging: a review. Food Anal Methods. 2017;10:3790–814.

    Article  Google Scholar 

  42. Brambilla G, D’Hollander W, Oliaei F, Stahl T, Weber R. Pathways and factors for food safety and food security at PFOS contaminated sites within a problem based learning approach. Chemosphere. 2015;129:192–202.

    Article  CAS  PubMed  Google Scholar 

  43. Domingo JL, Nadal M. Per- and polyfluoroalkyl substances (PFASs) in food and human dietary intake: a review of the recent scientific literature. J Agric Food Chem. 2017;65:533–43.

    Article  CAS  PubMed  Google Scholar 

  44. Trojanowicz M, Koc M. Recent developments in methods for analysis of perfluorinated persistent pollutants. Microchim Acta. 2013;180:957–71.

    Article  CAS  Google Scholar 

  45. Naughton DP, Nepusz T, Petroczi A. Network analysis: a promising tool for food safety. Curr Opin Food Sci. 2015;6:44–8.

    Article  Google Scholar 

  46. Alves A, Kucharska A, Erratico C, Xu F, Den Hond E, Koppen G, et al. Human biomonitoring of emerging pollutants through non-invasive matrices: state of the art and future potential. Anal Bioanal Chem. 2014;406:4063–88.

    Article  CAS  PubMed  Google Scholar 

  47. Farre M, Barcelo D. Analysis of emerging contaminants in food. Trends Anal Chem. 2013;43:240–53.

    Article  CAS  Google Scholar 

  48. Habe TT, Morlock GE. Miniaturization of instrumental planar chromatography with focus on mass spectrometry. Chromatographia. 2016;79:797–810.

    Article  CAS  Google Scholar 

  49. Morlock GE. Miniaturized planar chromatography using office peripherals – office chromatography. J Chromatogr A. 2015;1382:87–96.

    Article  CAS  PubMed  Google Scholar 

  50. Liu JM, Liu CC, Fang GZ, Wang S. Advanced analytical methods and sample preparation for ion chromatography techniques. RSC Adv. 2015;72:58713–26.

    Article  CAS  Google Scholar 

  51. Cutillas V, Martínez Galera M, Rajski Ł, Fernández-Alba AR. Evaluation of supercritical fluid chromatography coupled to tandem mass spectrometry for pesticide residues in food. J Chromatogr A. 2018;1545:67–74.

    Article  CAS  PubMed  Google Scholar 

  52. Fujito Y, Hayakawa Y, Izumi Y, Bamba T. Importance of optimizing chromatographic conditions and mass spectrometric parameters for supercritical fluid chromatography/mass spectrometry. J Chromatogr A. 2017;1508:138–47.

    Article  CAS  PubMed  Google Scholar 

  53. Ishibashi M, Izumi Y, Sakai M, Ando T, Fukusaki E, Bamba T. High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography coupled with high-resolution mass spectrometry. J Agric Food Chem. 2015;63:4457–63.

    Article  CAS  PubMed  Google Scholar 

  54. Ishibashi M, Ando T, Sakai M, Matsubara A, Uchikata T, Fukusaki E, et al. High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A. 2012;1266:143–8.

    Article  CAS  PubMed  Google Scholar 

  55. Garrido Frenich A, Romero-Gonzalez R, del Mar Aguilera-Ruiz M. Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS. Trends Anal Chem. 2014;63:158–69.

    Article  CAS  Google Scholar 

  56. Jandera P. Advances in the development of organic polymer monolithic columns and their applications in food analysis—a review. J Chromatogr A. 2013;1313:37–53.

    Article  CAS  PubMed  Google Scholar 

  57. Bernal J, Ares AM, Pol J, Wiedmar SK. Hydrophilic interaction liquid chromatography in food analysis. J Chromatogr A. 2011;42:7438–52.

    Article  CAS  Google Scholar 

  58. Keshet U, Alon T, Fialkov AB, Amirav A. Open probe fast GC-MS—combining ambient sampling ultra-fast separation and in-vacuum ionization for real-time analysis. J Mass Spectrom. 2017;52:417–26.

    Article  CAS  PubMed  Google Scholar 

  59. Seemann B, Alon T, Tsizin S, Fialkov AB, Amirav A. Electron ionization LC-MS with supersonic molecular beams—the concept, benefits and applications. J Mass Spectrom. 2015;50:1252–63.

    Article  CAS  PubMed  Google Scholar 

  60. Amirav A, Gordin A, Poliak M, Fialkov AB. Gas chromatography-mass spectrometry with supersonic molecular beams. J Mass Spectrom. 2008;43:141–63.

    Article  CAS  PubMed  Google Scholar 

  61. Rochat B. From targeted quantification to untargeted metabolomics: why LC-high-resolution-MS will become a key instrument in clinical labs. Trends Anal Chem. 2016;84:151–64.

    Article  CAS  Google Scholar 

  62. Senyuva HZ, Gokmen V, Sarikaya EA. Future perspectives in Orbitrap™-high-resolution mass spectrometry in food analysis: a review. Food Addit Contam A. 2015;32:1568–606.

    Article  CAS  Google Scholar 

  63. Wang J, Chow W, Chang J, Wong JW. Development and validation of a qualitative method for target screening of 448 pesticide residues in fruits and vegetables using UHPLC/ESI Q-Orbitrap based on data-independent acquisition and compound database. J Agric Food Chem. 2017;65:473–93.

    Article  CAS  PubMed  Google Scholar 

  64. Uclés S, Uclés A, Lozano A, Martínez Bueno MJ, Fernández-Alba AR. Shifting the paradigm in gas chromatography mass spectrometry pesticide analysis using high resolution accurate mass spectrometry. J Chromatogr A. 2017;1501:107–16.

    Article  CAS  PubMed  Google Scholar 

  65. Mol HGJ, Tienstra M, Zomer P. Evaluation of gas chromatography - electron ionization—full scan high resolution Orbitrap mass spectrometry for pesticide residue analysis. Anal Chim Acta. 2016;935:161–72.

    Article  CAS  PubMed  Google Scholar 

  66. Barcaru A, Mol HGJ, Tienstra M, Vivó-Truyols G. Bayesian approach to peak deconvolution and library search for high resolution gas chromatography–mass spectrometry. Anal Chim Acta. 2017;983:76–90.

    Article  CAS  PubMed  Google Scholar 

  67. Bylinski H, Gebicki J, Dymerski T, Namiesnik J. Direct analysis of samples of various origin and composition using specific types of mass spectrometry. Crit Rev Anal Chem. 2017;47:340–58.

    Article  CAS  PubMed  Google Scholar 

  68. Guo TY, Yong W, Jin Y, Zhang LY, Liu JH, Wang S, et al. Applications of DART-MS for food quality and safety assurance in food supply chain. Mass Spectrom Rev. 2017;36:161–87.

    Article  CAS  PubMed  Google Scholar 

  69. Kern SE, Lin LA, Fricke FL. Accurate mass fragment library for rapid analysis of pesticides on produce using ambient pressure desorption ionization with high-resolution mass spectrometry. J Am Soc Mass Spectrom. 2014;25:1482–8.

    Article  CAS  PubMed  Google Scholar 

  70. Hernandez-Mesa M, Escourrou A, Monteau F, Le Bizec B, Dervilly-Pinel G. Current applications and perspectives of ion mobility spectrometry to answer chemical food safety issues. Trends Anal Chem. 2017;94:39–53.

    Article  CAS  Google Scholar 

  71. Piras C, Roncada P, Rodrigues PM, Bonizzi L, Soggiu A. Proteomics in food: quality, safety, microbes, and allergens. Proteomics. 2016;16:799–815.

    Article  CAS  PubMed  Google Scholar 

  72. Fagerquist CK. Unlocking the proteomic information encoded in MALDI-TOF-MS data used for microbial identification and characterization. Expert Rev Proteomics. 2017;14:97–107.

    Article  CAS  PubMed  Google Scholar 

  73. Huber I, Pavlovic M, Maggipinto M, Konrad R, Busch U. Interlaboratory proficiency test using MALDI-TOF MS for identification of food-associated bacteria. Food Anal Methods. 2018;11:1068–75.

    Article  Google Scholar 

  74. Wang X, Wang SJ, Cai ZW. The latest developments and applications of mass spectrometry in food-safety and quality analysis. Trends Anal Chem. 2013;52:170–85.

    Article  CAS  Google Scholar 

  75. Golf O, Strittmatter N, Karancsi T, Pringle SD, Speller AVM, Mroz A, et al. Rapid evaporative ionization mass spectrometry imaging platform for direct mapping from bulk tissue and bacterial growth media. Anal Chem. 2015;87:2527–34.

    Article  CAS  PubMed  Google Scholar 

  76. Beach DG, Walsh CM, Cantrell P, Rourke W, O’Brien S, Reeves K, et al. Laser ablation electrospray ionization high-resolution mass spectrometry for regulatory screening of domoic acid in shellfish. Rapid Commun Mass Spectrom. 2016;30:2379–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Raynie DE. Trends in sample preparation. LCGC N Am. 2016;34:174–88.

    CAS  Google Scholar 

  78. Wen YY, Chen L, Li JH, Liu DY, Chen LX. Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis. Trends Anal Chem. 2014;59:26–41.

    Article  CAS  Google Scholar 

  79. Plotka-Wasylka J, Szczepanska N, de la Guardia M, Namiesnik J. Modern trends in solid-phase extraction: new sorbent media. Trends Anal Chem. 2016;77:26–43.

    Article  CAS  Google Scholar 

  80. Arsenault JC. Beginner’s guide to SPE: solid-phase extraction. Milford: Waters Corp; 2012. 212 pp

    Google Scholar 

  81. Andrade-Eiroa A, Canle M, Leroy-Cancellieri V, Cerda V. Solid-phase extraction of organic compounds: a critical review. Trends Anal Chem. 2016;80:655–67.

    Article  CAS  Google Scholar 

  82. De Toffoli AL, Soares Maciel EV, Fumes BH, Lancas FM. The role of graphene-based sorbents in modern sample preparation techniques. J Sep Sci. 2018;41:288–302.

    Article  CAS  PubMed  Google Scholar 

  83. Jakubus A, Paszkiewicz M, Stepnowski P. Carbon nanotubes application in the extraction techniques of pesticides: a review. Crit Rev Anal Chem. 2017;47:76–91.

    Article  CAS  PubMed  Google Scholar 

  84. Herrero Latorre C, Álvarez Méndez J, Barciela García J, García Martín S, Peña Crecente RM. Carbon nanotubes as solid-phase extraction sorbents prior to atomic spectrometric determination of metal species: a review. Anal Chim Acta. 2012;749:16–35.

    Article  CAS  PubMed  Google Scholar 

  85. Herrero-Latorre C, Barciela-García J, García-Martín S, Peña-Crecente RM, Otarola-Jimenez J. Magnetic solid-phase extraction using carbon nanotubes as sorbents: a review. Anal Chim Acta. 2015;892:10–26.

    Article  CAS  PubMed  Google Scholar 

  86. Morris BD, Schriner RB. Development of an automated column solid-phase extraction cleanup of QuEChERS extracts, using zirconia-based sorbent, for pesticide residue analyses by LC-MS/MS. J Agric Food Chem. 2015;63:5107–19.

    Article  CAS  PubMed  Google Scholar 

  87. Khezeli T, Daneshfar A. Development of dispersive micro-solid phase extraction based on micro and nano sorbents. Trends Anal Chem. 2017;89:99–118.

    Article  CAS  Google Scholar 

  88. Bordin DCM, Alves MNR, de Campos EG, De Martinis BS. Disposable pipette tips extraction: fundamentals, applications, and state of the art. J Sep Sci. 2016;39:1168–72.

    Article  CAS  PubMed  Google Scholar 

  89. Anastassiades M, Lehotay SJ, Štajnbaher D, Schenck FJ. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J AOAC Int. 2003;86:412–31.

    CAS  PubMed  Google Scholar 

  90. González-Curbelo MÁ, Socas-Rodríguez B, Herrera-Herrera AV, González-Sálamo J, Hernández-Borges J, Rodríguez-Delgado MÁ. Evolution and applications of the QuEChERS method. Trends Anal Chem. 2015;71:169–85.

    Article  CAS  Google Scholar 

  91. Rejczak T, Tuzimski T. A review of recent developments and trends in the QuEChERS sample preparation approach. Open Chem. 2015;13:980–1010.

    Article  Google Scholar 

  92. Bruzzoniti MC, Checchini L, De Carlo RM, Orlandini S, Rivoira L, Del Bubba M. QuEChERS sample preparation for the determination of pesticides and other organic residues in environmental matrices: a critical review. Anal Bioanal Chem. 2014;406:4089–116.

    Article  CAS  PubMed  Google Scholar 

  93. Steinborn A, Alder L, Spitzke M, Doerk D, Anastassiades M. Development of a QuEChERS-based method for the simultaneous determination of acidic pesticides, their esters, and conjugates following alkaline hydrolysis. J Agric Food Chem. 2017;65:1296–305.

    Article  CAS  PubMed  Google Scholar 

  94. Shao G, Agar J, Giese RW. Cold-induced aqueous acetonitrile phase separation: a salt-free way to begin quick, easy, cheap, effective, rugged, safe. J Chromatogr A. 2017;1506:128–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Arthur CL, Pawliszyn J. Solid-phase microextraction with thermal-desorption using fused-silica optical fibers. Anal Chem. 1990;62:2145–8.

    Article  CAS  Google Scholar 

  96. Reyes-Garcés N, Gionfriddo E, Gómez-Ríos GA, Alam MN, Boyacı E, Bojko B, et al. Advances in solid-phase microextraction and perspective on future directions. Anal Chem. 2018;90:302–60.

    Article  CAS  PubMed  Google Scholar 

  97. Souza-Silva EA, Gionfriddo E, Pawliszyn J. A critical review of the state of the art of solid-phase microextraction of complex matrices II. Food analysis. Trends Anal Chem. 2015;71:236–48.

    Article  CAS  Google Scholar 

  98. Costa R. Newly introduced sample preparation techniques: towards miniaturization. Crit Rev Anal Chem. 2014;44:299–310.

    Article  CAS  PubMed  Google Scholar 

  99. Martín-Calero A, Pino V, Afonso AM. Ionic liquids as a tool for determination of metals and organic compounds in food analysis. Trends Anal Chem. 2011;30:1598–619.

    Article  CAS  Google Scholar 

  100. Trujillo-Rodríguez MJ, Rocío-Bautista P, Pino V, Afonso AM. Ionic liquids in dispersive liquid-liquid microextraction. Trends Anal Chem. 2013;51:87–106.

    Article  CAS  Google Scholar 

  101. Kokosa JM. Advances in solvent-microextraction techniques. Trends Anal Chem. 2013;43:2–13.

    Article  CAS  Google Scholar 

  102. Hernández-Hernández AA, Álvarez-Romero GA, Contreras-López E, Aguilar-Artega K, Castañeda-Ovando A. Food analysis by microextraction methods based on the use of magnetic nanoparticles as supports: recent advances. Food Anal Methods. 2017;10:2974–93.

    Article  Google Scholar 

  103. Bendicho C, Costas-Mora I, Romero V, Lavilla I. Nanoparticle-enhanced liquid-phase microextraction. Trends Anal Chem. 2015;68:78–87.

    Article  CAS  Google Scholar 

  104. Lehotay SJ, Han L, Sapozhnikova Y. Automated mini-column solid-phase extraction cleanup for high-throughput analysis of chemical contaminants in foods by low-pressure gas chromatography–tandem mass spectrometry. Chromatographia. 2016;79:1113–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Raynie DE, Qiu C. The use of extraction technologies in food safety studies. LCGC N Am. 2017;35:158–69.

    Google Scholar 

  106. Lawal A, Tan GH, Alsharif AMA. Recent advances in analysis of pesticides in food and drink samples using LPME techniques coupled to GC-MS and LC-MS: a review. J AOAC Int. 2016;99:1383–94.

    Article  CAS  PubMed  Google Scholar 

  107. Lehotay SJ, Cook JM. Sampling and sample processing in pesticide residue analysis. J Agric Food Chem. 2015;63:4395–404.

    Article  CAS  PubMed  Google Scholar 

  108. Whitaker TB. Sampling foods for mycotoxins. Food Addit Contam. 2006;23:50–61.

    Article  CAS  PubMed  Google Scholar 

  109. Bodnar M, Namieśnik J, Konieczka P. Validation of a sampling procedure. Trends Anal Chem. 2013;51:117–26.

    Article  CAS  Google Scholar 

  110. Riter LS, Lynn KJ, Wujcik CE, Bucholz LM. Interlaboratory assessment of cryomilling sample preparation for residue analysis. J Agric Food Chem. 2015;63:4405–8.

    Article  CAS  PubMed  Google Scholar 

  111. Mandal V, Tandey R. A critical analysis of publication trends from 2005-2015 in microwave assisted extraction of botanicals: how far have come and the road ahead. Trends Anal Chem. 2016;82:100–8.

    Article  CAS  Google Scholar 

  112. Wang H, Ding J, Ren NQ. Recent advances in microwave-assisted extraction of trace organic pollutants from food and environmental samples. Trends Anal Chem. 2016;75:197–208.

    Article  CAS  Google Scholar 

  113. Sun HW, Ge XS, Lv YK, Wang AB. Application of accelerated solvent extraction in the analysis of organic contaminants, bioactive and nutritional compounds in food and feed. J Chromatogr A. 2012;1237:1–23.

    Article  CAS  PubMed  Google Scholar 

  114. Capriotti AL, Cavaliere C, Giansanti P, Gubbiotti R, Samperi R, Lagana A. Recent developments in matrix solid-phase dispersion. J Chromatogr A. 2010;1217:2521–32.

    Article  CAS  PubMed  Google Scholar 

  115. He M, Chen BB, Hu B. Recent developments in stir bar sorptive extraction. Anal Bioanal Chem. 2014;406:2001–26.

    Article  CAS  PubMed  Google Scholar 

  116. Seidi S, Yamini Y. Analytical sonochemistry; developments applications, and hyphenations of ultrasound in sample preparation and analytical techniques. Central Eur J Chem. 2012;10:938–76.

    Google Scholar 

  117. Ma F, Wu R, Li PW, Li Y. Analytical approaches for measuring pesticides, mycotoxins and heavy metals in vegetable oils: a review. Eur J Lipid Sci Technol. 2016;118:339–52.

    Article  CAS  Google Scholar 

  118. Hoogenboom R, Traag W, Fernandes A, Rose M. European developments following incidents with dioxins and PCBs in the food and feed chain. Food Control. 2015;50:670–83.

    Article  CAS  Google Scholar 

  119. Subedi B, Aguilar L, Robinson EM, Hageman KJ, Bjorklund E, Sheesley RJ, et al. Selective pressurized liquid extraction as a sample-preparation technique for persistent organic pollutants and contaminants of emerging concern. Trends Anal Chem. 2015;68:119–32.

    Article  CAS  Google Scholar 

  120. Bylda C, Thiele R, Kobold U, Volmer DA. Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS/MS. Analyst. 2014;139:2265–76.

    Article  CAS  PubMed  Google Scholar 

  121. Han L, Matarrita J, Sapoznikova Y, Lehotay SJ. Evaluation of a recent product to remove lipids and other matrix co-extractives in the analysis of pesticide residues and environmental contaminants in foods. J Chromatogr A. 2016;1449:17–29.

    Article  CAS  PubMed  Google Scholar 

  122. Zhao L, Lucas D, Long D, Richter B, Stevens J. Multi-class multi-residue analysis of veterinary drugs in meat using enhanced matrix removal lipid cleanup and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2018;1549:14–24.

    Article  CAS  PubMed  Google Scholar 

  123. Sellergren B, Ekberg B, Mosbach K. Molecular imprinting of amino-acid derivatives in macroporous polymers–demonstration of substrate-selectivity and enantio-selectivity by chromatographic resolution of racemic mixtures of amino-acid derivatives. J Chromatogr. 1985;347:1–10.

    Article  CAS  Google Scholar 

  124. Ashley J, Shahbazi MA, Kant K, Chidambara VA, Wolff A, Bang DD, et al. Molecularly imprinted polymers for sample preparation and biosensing in food analysis: progress and perspectives. Biosens Bioelectron. 2017;94:606–15.

    Article  CAS  Google Scholar 

  125. Speltini A, Scalabrini A, Maraschi F, Sturini M, Profumo A. Newest applications of molecularly imprinted polymers for extraction of contaminants from environmental and food matrices: a review. Anal Chim Acta. 2017;974:1–26.

    Article  CAS  PubMed  Google Scholar 

  126. Wang PL, Sun XH, Su XO, Wang T. Advancements of molecularly imprinted polymers in the food safety field. Analyst. 2016;141:3540–53.

    Article  CAS  PubMed  Google Scholar 

  127. International Standards Organization. ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories. Mar. 2018 (corrected version), www.iso.org/standard/66912. Accessed Apr 2018.

  128. Valcárel M, Lucena R. Synergistic relationships between analytical chemistry and written standards. Anal Chim Acta. 2013;788:1–7.

    Article  CAS  Google Scholar 

  129. Esbensen KH, Wagner C. Theory of sampling (TOS) versus measurement uncertainty (MU)—a call for integration. Trends Anal Chem. 2014;57:93–106.

    Article  CAS  Google Scholar 

  130. Madeiros de Albano F, Schwengber ten Caten C. Proficiency tests for laboratories: a systematic review. Accred Qual Assur. 2014;19:245–57.

    Article  Google Scholar 

  131. Wise SA. What is novel about certified reference materials? Anal Bioanal Chem. 2018;410:2045–9.

    Article  CAS  PubMed  Google Scholar 

  132. Ferrer C, Lozano A, Uclés S, Valverde A, Fernández-Alba AR. European Union proficiency tests for pesticide residues in fruit and vegetables from 2009 to 2016: overview of the results and main achievements. Food Control. 2017;82:101–13.

    Article  CAS  Google Scholar 

  133. Franceschi P, Giordan M, Wehrens R. Multiple comparisons in mass-spectometry-based—omics technologies. Trends Anal Chem. 2013;50:11–21.

    Article  CAS  Google Scholar 

  134. Ropodi AI, Panagou EZ, G-JE N. Data mining derived from food analyses using non-invasive/non-destructive analytical techniques; determination of food authenticity, quality & safety in tandem with computer science disciplines. Trends Food Sci Technol. 2016;50:11–25.

    Article  CAS  Google Scholar 

  135. Burfield R, Neumann C, Saunders CP. Review and application of functional data analysis to chemical data—the example of the comparison, classification, and database search of forensic ink chromatograms. Chemom Intell Lab Syst. 2015;149:97–106.

    Article  CAS  Google Scholar 

  136. Rodionova OY, Titova AV, Pomerantzev AL. Discriminant analysis is an inappropriate method of authentication. Trends Anal Chem. 2016;78:17–22.

    Article  CAS  Google Scholar 

  137. Andersen JET. On the development of quality assurance. Trends Anal Chem. 2014;60:16–24.

    Article  CAS  Google Scholar 

  138. European Commission Directorate General for Health and Food Safety, Guidance document on analytical quality control and method validation procedures for pesticide residues and analysis in food and feed. SANTE/11813/2017.

  139. Lehotay SJ, Sapozhnikova Y, Mol HGJ. Current issues involving screening and identification of chemical contaminants in foods by mass spectrometry. Trends Anal Chem. 2015;69:62–75.

    Article  CAS  Google Scholar 

  140. Lehotay SJ, Mastovska K, Amirav A, Fialkov AB, Alon T, Martos PA, et al. Identification and confirmation of chemical residues in food by chromatography-mass spectrometry and other techniques. Trends Anal Chem. 2008;27:1070–90.

    Article  CAS  Google Scholar 

  141. Ellison SLR, Hardcastle WA. Causes of error in analytical chemistry: results of web-based survey of proficiency testing participants. Accred Qual Assur. 2012;17:453–64.

    Article  Google Scholar 

  142. Ambrus Á, Zentai A, Sali J, Ficzere I. Hidden contributors to uncertainty and accuracy of results of residue analysis. Accred Qual Assur. 2011;16:3–11.

    Article  Google Scholar 

  143. Kuselman I, Pennechi F, Epstein M, Fajgelj A, Ellison SLR. Monte Carlo simulation of expert judgments on human errors in chemical analysis—a case study of ICP-MS. Talanta. 2014;130:462–9.

    Article  CAS  PubMed  Google Scholar 

  144. Kuselman I, Pennecchi F, Bich W, Hibbert DB. Human being as a part of measuring system influencing measurement results. Accred Qual Assur. 2016;21:421–4.

    Article  Google Scholar 

  145. Kuselman I, Pennecchi F. Human errors and measurement uncertainty. Metrologia. 2015;52:238–43.

    Article  CAS  Google Scholar 

  146. Kovac J. What is an ethical chemist? Chimia. 2017;71:38–43.

    Article  CAS  PubMed  Google Scholar 

  147. Knolhoff AM, Croley TR. Non-targeted screening approaches for contaminants and adulterants in food using liquid chromatography hyphenated to high resolution mass spectrometry. J Chromatogr A. 2016;1428:86–96.

    Article  CAS  PubMed  Google Scholar 

  148. Koster S, Boobis AR, Cubberly R, Hollnagel HM, Richling E, Wildemann T, et al. Application of the TTC concept to unknown substances found in analysis of foods. Food Chem Toxicol. 2011;49:1643–60.

    Article  CAS  PubMed  Google Scholar 

  149. Asnin LD. Peak measurement and calibration in chromatographic analysis. Trends Anal Chem. 2016;81:51–62.

    Article  CAS  Google Scholar 

  150. Van Stee LLP, Brinkman UAT. Peak detection methods for GC × GC: an overview. Trends Anal Chem. 2016;83:1–13.

    Article  CAS  Google Scholar 

  151. Isaacman-VanWertz G, Sueper DT, Aikin KC, Lerner BM, Gilman JB, de Gouw JA, et al. Automated single-ion peak fitting as an efficient approach for analyzing complex chromatographic data. J Chromatogr A. 2017;1529:81–92.

    Article  CAS  PubMed  Google Scholar 

  152. Lehotay SJ. Utility of the summation chromatographic peak integration function to avoid manual reintegrations in the analysis of targeted analytes. LCGC N Am. 2017;35:391–402.

    CAS  Google Scholar 

  153. Andrade JM, Estévez-Pérez MG. Statistical comparison of the slopes of two regression lines: a tutorial. Anal Chim Acta. 2014;838:1–12.

    Article  CAS  PubMed  Google Scholar 

  154. Francq BG, Govaerts BB. Measurement methods comparison with errors-in-variables regressions. From horizontal to vertical OLS regression, review and new perspectives. Chemom Intell Lab Syst. 2014;134:123–39.

    Article  CAS  Google Scholar 

  155. Nanita SC, Kaldon LG. Emerging flow injection mass spectrometry methods for high-throughput quantitative analysis. Anal Bioanal Chem. 2016;408:23–33.

    Article  CAS  PubMed  Google Scholar 

  156. Samarajeewa U, Wei CI, Huang TS, Marshall MR. Application of immunoassay in the food-industry. Crit Rev Food Sci Nutr. 1991;29:403–34.

    Article  CAS  PubMed  Google Scholar 

  157. Li YF, Sun YM, Beier RC, Lei HT, Gee S, Hammock BD, et al. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: a review. Trends Anal Chem. 2017;88:25–40.

    Article  CAS  Google Scholar 

  158. Jha SN, Jaiswal P, Grewal MK, Gupta M, Bhardwaj R. Detection of adulterants and contaminants in liquid foods—a review. Crit Rev Food Sci Nutr. 2016;56:1662–84.

    Article  CAS  PubMed  Google Scholar 

  159. McGrath TF, Elliott CT, Fodey TL. Biosensors for the analysis of microbiological and chemical contaminants in food. Anal Bioanal Chem. 2012;403:75–92.

    Article  CAS  PubMed  Google Scholar 

  160. Liu AP, Anfossi L, Shen L, Li C, Wang XH. Non-competitive immunoassay for low-molecular-weight contaminants detection in food, feed and agricultural products: a mini-review. Trends Food Sci Technol. 2018;71:181–7.

    Article  CAS  Google Scholar 

  161. Yan X, Li HX, Yan Y, Su XG. Developments in pesticide analysis by multi-analyte immunoassays: a review. Anal Methods. 2014;6:3543–54.

    Article  CAS  Google Scholar 

  162. Unger RH, Eisentraut AM, McCall MS, Keller S, Lanz HC, Madison LL. Glucagon antibodies and their use for immunoassay for glucagon. Proc Soc Exp Biol Med. 1959;102:621–3.

    Article  CAS  PubMed  Google Scholar 

  163. Hird SJ, Lau BPY, Schuhmacher R, Krska R. Liquid chromatography-mass spectrometry for the determination of chemical contaminants in food. Trends Anal Chem. 2014;59:59–72.

    Article  CAS  Google Scholar 

  164. Gomaa A, Boye J. Simultaneous detection of multi-allergens in a food matrix using ELISA, multiplex flow cytometry and liquid chromatography mass spectrometry (LC-MS). Food Chem. 2015;175:585–92.

    Article  CAS  PubMed  Google Scholar 

  165. De Medici D, Kuchta T, Knuttson R, Angelov A, Auricchio B, Barbanera M, et al. Rapid methods for quality assurance of foods: the next decade with polymerase chain reaction (PCR)-based food monitoring. Food Anal Methods. 2015;8:255–71.

    Article  Google Scholar 

  166. Goudreau DN, Smith M, EM MC, Ruscito A, Velu R, Callahan J, et al. Aptamer-based sensing techniques for food safety and quality. In: Lu X, editor. Sensing techniques for food safety and quality control. Cambridge: Royal Society of Chemistry; 2017. p. 200–71.

    Chapter  Google Scholar 

  167. Duan N, Wu SJ, Dai SL, Gu HJ, Hao LL, Ye H, et al. Advances in aptasensors for the detection of food contaminants. Analyst. 2016;141:3942–61.

    Article  CAS  PubMed  Google Scholar 

  168. Wegner KD, Tran MV, Massey M, Algar WR. Quantum dots in the analysis of food safety and quality. In: Lu X, editor. Sensing techniques for food safety and quality control. Cambridge: Royal Society of Chemistry; 2017. p. 17–60.

    Chapter  Google Scholar 

  169. Zhou JW, Zou XM, Song SH, Chen GH. Quantum dots applied to methodology on detection of pesticide and veterinary drug residues. J Agric Food Chem. 2018;66:1307–19.

    Article  CAS  PubMed  Google Scholar 

  170. Yaseen T, Sun DW, Cheng JH. Raman imaging for food quality and safety evaluation: fundamentals and applications. Trends Food Sci Technol. 2017;62:177–89.

    Article  CAS  Google Scholar 

  171. Yaseen T, Pu HB, Sun DW. Functionalization techniques for improving SERS substrates and their applications in food safety evaluation: a review of recent research trends. Trends Food Sci Technol. 2018;72:162–74.

    Article  CAS  Google Scholar 

  172. Hao N, Wang K. Recent development of electrochemiluminescence sensors for food analysis. Anal Bioanal Chem. 2016;408:7035–48.

    Article  CAS  PubMed  Google Scholar 

  173. Rotariu L, Lagarde F, Jaffrezic-Renault N, Bala C. Electrochemical biosensors for fast detection of food contaminants trends and perspective. Trends Anal Chem. 2016;79:80–7.

    Article  CAS  Google Scholar 

  174. Reverte L, Prieto-Simon B, Campas M. New advances in electrochemical biosensors for the detection of toxins: nanomaterials, magnetic beads and microfluidic systems. A review. Anal Chim Acta. 2016;908:8–21.

    Article  CAS  PubMed  Google Scholar 

  175. Lehotay SJ, Lu X. Sensing techniques for food safety and quality control. Anal Bioanal Chem. 2018;410:2271–2.

    Article  CAS  Google Scholar 

  176. Soares RG, Ricelli A, Fanelli C, Caputo D, de Cesare G, Chu V, et al. Advances, challenges and opportunities for point-of-needs screening of mycotoxins in foods and feeds. Analyst. 2018;143:1015–35.

    Article  CAS  PubMed  Google Scholar 

  177. Marcinkowska M, Baralkiewicz D. Multielemental speciation analysis by advanced hyphenated technique—HPLC/ICP-MS: a review. Talanta. 2016;161:177–204.

    Article  CAS  PubMed  Google Scholar 

  178. Hajeb P, Sloth JJ, Shakibazadeh S, Mahyudin NA, Afsah-Hejri L. Toxic elements in food: occurrence, binding, and reduction approaches. Compr Rev Food Sci Food Saf. 2014;13:457–72.

    Article  CAS  Google Scholar 

  179. Peng JY, Liu F, Zhou F, Song KL, Zhang C, Ye LH, et al. Challenging applications for multi-element analysis by laser-induced breakdown spectroscopy in agriculture: a review. Trends Anal Chem. 2016;85:260–72.

    Article  CAS  Google Scholar 

  180. Markiewicz-Keszycka M, Cama-Moncunill X, Casado-Gavalda MP, Dixit Y, Cama-Moncunill R, Cullen PJ, et al. Laser-induced breakdown spectroscopy (LIBS) for food analysis: a review. Trends Food Sci Technol. 2017;65:80–93.

    Article  CAS  Google Scholar 

  181. Butcher DJ. Atomic fluorescence spectrometry: a review of advances in instrumentation and novel applications. Appl Spectrosc Rev. 2016;51:397–416.

    Article  CAS  Google Scholar 

  182. Taylor A, Barlow N, Day MP, Hill S, Patriarca M, White M. Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages. J Anal At Spectrom. 2017;32:432–76.

    Article  CAS  Google Scholar 

Download references

Disclaimer

The opinions expressed in this article are those of the authors and do not reflect the views of the US Dept. of Agriculture (USDA). Mention of brand or firm name does not constitute an endorsement by the USDA above others of a similar nature not mentioned.

Funding

This project was supported in part by a subaward from the University of Kentucky Research Foundation (UKRF) in grant no. 3048108028-11-342 from the National Institute for Hometown Security.

Author information

Authors and Affiliations

  1. U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA, 19038, USA

    Steven J. Lehotay & Yibai Chen

  2. Arcadia University, 450 South Easton Road, Glenside, PA, 19038, USA

    Yibai Chen

Authors
  1. Steven J. Lehotay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yibai Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Steven J. Lehotay.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Published in the topical collection Food Safety Analysis with guest editor Steven J. Lehotay.

Electronic supplementary material

ESM 1

(PDF 475 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lehotay, S.J., Chen, Y. Hits and misses in research trends to monitor contaminants in foods. Anal Bioanal Chem 410, 5331–5351 (2018). https://doi.org/10.1007/s00216-018-1195-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-018-1195-3

Keywords

Search

Navigation