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Sampling and analyte enrichment strategies for ambient mass spectrometry

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Abstract

Ambient mass spectrometry provides great convenience for fast screening, and has showed promising potential in analytical chemistry. However, its relatively low sensitivity seriously restricts its practical utility in trace compound analysis. In this review, we summarize the sampling and analyte enrichment strategies coupled with nine modes of representative ambient mass spectrometry (desorption electrospray ionization, paper vhspray ionization, wooden-tip spray ionization, probe electrospray ionization, coated blade spray ionization, direct analysis in real time, desorption corona beam ionization, dielectric barrier discharge ionization, and atmospheric-pressure solids analysis probe) that have dramatically increased the detection sensitivity. We believe that these advances will promote routine use of ambient mass spectrometry.

Scheme of sampling stretagies for ambient mass spectrometry

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Acknowledgements

The authors are grateful for financial support from the Research and Application of the Common Technology of National Quality Infrastructure (grant no. 2016YFF0201106) and the National Natural Science Foundation of China (grant no. 21305159, 21575007, and 21527809).

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Authors and Affiliations

  1. Food Safety Laboratory, Division of Metrology in Chemistry, National Institute of Metrology, No.18, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China

    Xianjiang Li & Hongmei Li

  2. Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Zhongguancun Street, Beijing, 100871, China

    Xianjiang Li, Wen Ma, Wanpeng Ai, Yu Bai & Huwei Liu

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  1. Xianjiang Li
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Li, X., Ma, W., Li, H. et al. Sampling and analyte enrichment strategies for ambient mass spectrometry. Anal Bioanal Chem 410, 715–724 (2018). https://doi.org/10.1007/s00216-017-0658-2

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