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The synthesis and screening of the antimicrobial activity of some novel 3-(furan-2-yl)-1-(aryl)-3-(phenylthio) propan-1-one derivatives

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Abstract

A series of thiophenol adducts (3a–m) were prepared by addition of thiophenol to chalcones (1a–m) in the presence of a catalytic amount of KOt-Bu in solvent free conditions. In addition, the antibacterial and antifungal in vitro properties were tested against some human pathogenic microorganisms by employing the disk diffusion technique. A majority of compounds were remarkably active against several of the microorganisms. Compound 3i was determined to be the most active compound.

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Acknowledgments

The authors are indebted to the Technical Research Council of Turkey (Grant TUBITAK-106T103) for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, 60110, Tokat, Turkey

    Mustafa Ceylan, Meliha Burcu Gürdere & Hayreddin Gezegen

  2. Department of Biology, Faculty of Arts and Sciences, Gaziosmanpasa University, 60250, Tokat, Turkey

    İsa Karaman

Authors
  1. Mustafa Ceylan
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  2. Meliha Burcu Gürdere
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  3. İsa Karaman
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  4. Hayreddin Gezegen
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Correspondence to Mustafa Ceylan.

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Ceylan, M., Gürdere, M.B., Karaman, İ. et al. The synthesis and screening of the antimicrobial activity of some novel 3-(furan-2-yl)-1-(aryl)-3-(phenylthio) propan-1-one derivatives. Med Chem Res 20, 109–115 (2011). https://doi.org/10.1007/s00044-009-9279-4

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  • DOI: https://doi.org/10.1007/s00044-009-9279-4

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