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Phagocytosis of polymer microspheres by macrophages

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New Polymer Materials

Part of the book series: Advances in Polymer Science ((POLYMER,volume 94))

Abstract

This article reviews the phagocytosis of polymer microspheres by macrophages with respect to the size and the surface characteristics of the microspheres. Since few investigations have been carried out using well-characterized polymer microspheres, the authors have emphasized own experimental results. The findings provide useful information on the development of polymer microspheres as carriers for drug delivery systems.

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Abbreviations

PVA:

poly(vinyl alcohol)

PE:

polyethylene

PP:

polypropylene

PTFE:

polytetrafluoroethylene

PET:

poly(ethylene terephthalate)

PMMA:

poly(methyl methacrylate)

PHEG:

poly(N-hydroxyethyl-l-glutamine)

PAAm:

polyacrylamide

CMC:

carboxymethyl cellulose

PVP:

poly(vinyl pyrrolidone)

PLLA:

poly(l-lactic acid)

PDLLA:

poly(d,l-lactic acid)

PGA:

poly(glycolic acid)

PGLA:

copolymer of l-lactic acid and glycolic acid

BSA:

bovine serum albumin

IgG:

bovine immunoglobulin G

FN:

human plasma fibronectin

Cell-OH:

cellulose

Cell-CM:

cellulose having the carboxymethyl group

Cell-SE:

cellulose having the sulfoethyl group

Cell-DEAE:

cellulose having the diethylaminoethyl group

Cell-DEAE(Me):

cellulose having the methyl quanternary salt of DEAE

Cell-NH2 :

cellulose having the primary amino group

Cell-C1 :

cellulose grafted with methyl chain

Cell-C2 :

cellulose grafted with ethyl chain

Cell-C3 :

cellulose grafted with n-propyl chain

Cell-C4 :

cellulose grafted with n-butyl chain

Cell-C6 :

cellulose grafted with n-hexyl chain

Cell-C8 :

cellulose grafted with n-octyl chain

Cell-C10 :

cellulose grafted with n-decyl chain

Cell-C12 :

cellulose grafted with n-dodecyl chain

Cell-C16 :

cellulose grafted with n-hexadecyl chain

Cell-C18 :

cellulose grafted with n-octadecyl chain

Cell-φ:

cellulose grafted with phenyl chain

Cell-â—¯:

cellulose grafted with cyclohexyl chain

Cell-g-BSA:

cellulose grafted with BSA

Cell-g-IgG:

cellulose grafted with IgG

Cell-g-FN:

cellulose grafted with FN

Cell-g-Tuft.:

cellulose grafted with tuftsin

Cell-g-Gel.:

cellulose grafted with gelatin

PBS:

phosphate-buffered saline solution (pH 7.4)

PBS(+):

PBS-containing Ca2+ and Mg2+ ions

CNBr:

cyanogen bromide

FCS:

fetal calf serum

MPS:

mononuclear phagocyte system

Mφ:

macrophage

SEM:

scanning electron microscopy

TEM:

transmission electron microscopy

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  1. Research Center for Medical Polymers and Biomaterials, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Yasuhiko Tabata & Yoshito Ikada

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  1. Yasuhiko Tabata
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Tabata, Y., Ikada, Y. (1990). Phagocytosis of polymer microspheres by macrophages. In: New Polymer Materials. Advances in Polymer Science, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0043062

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  • DOI: https://doi.org/10.1007/BFb0043062

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