Abstract
The use of dietary ω3 fatty acid capsules has been associated with a decrease in plasma triglyceride levels. In addition, populations consuming diets rich in fish appear to have a decreased incidence of cardiovascular disease. Eicosapentaenoic acid (EPA, 20∶5ω3) and docosahexaenoic acid (DHA, 22∶6ω3) are major fatty acids in fish oils. It is believed that fish oils exert their biolotic effect through these fatty acids. Many individuals are currently taking fish oil capsules to lower lipids, increase bleeding time, and possibly decrease cardiovascular risk. These capsules also have been classified as food additives with less stringent controls on content. We assessed the fatty acid, cholesterol, and vitamin A and E content of eight commercially available capcules along with cod liver oil. The content of EPA was found to range from 8.7–26.4% (wt%) with a mean of 17.3% (82.4% of labeled content), and that of DHA from 8.9–17.4% with a mean of 11.5% (90.0% of labeled content) as assessed by capillary column gas-liquid chromatography. The mean content of the polyunsaturated ω3 fatty acids was 31.9%, and that of the ω6 fatty acids was 1.4%. The content of saturated fatty acids was 32,0%, and that of monounsaturated fatty acids was 25.1%. Cholesterol content was low, with a range of 0.7–8.3 mg/g, the α-tocopherol range was 0.62–2.24 mg/g, and the range of retinyl esters was 0.4–298.4 μg/g. Cod liver oil had substantially more retinyl esters (2450.1 μg/g) than did fish oil capsules. Our data serve as an independent guide to fish oil capsule fatty acid content upon single lot analysis, and indicate that these capsules contain as much saturated fat as they contain ω3 fatty acids.
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Abbreviations
- EPA:
-
eicosapentaeonoic acid
- DHA:
-
docosahexaenoic acid
- FID:
-
flame ionization detector
- GC:
-
gas chromatograph
- FAME:
-
fatty acid methyl esters
References
Phillipson, B.E., Rothrock, D.W., Connor, W.E., Harris, W.S., and Illingworth, D.R. (1985)N. Engl. J. Med. 312:1210–1216.
Schacky, C.V., Fisher, S., and Weber, P.C. (1985)J. Clin. Invest. 76:1626–1631.
Simons, L.A., Hickie, J.B., and Balasubramaniam, S. (1985)Atherosclerosis 54:75–88.
Vas Dias, F.W., Gibney, M.J., and Tayler, T.G. (1982)Atherosclerosis 43:245–257.
Fischer, S., and Weber, P.C. (1983)Biochem. Biophys. Res. Commun. 116:1091–1099.
Fischer, S., and Weber, P.C. (1984)Nature, 307:165–168.
Lee, T.H., Hoover, R.L., Williams, J.D., Sperling, R.S., Ravalese, III, J., Spur, B.W., Robinson, D.R., Corey, E.J., Lewis, R.A., and Austen, K.F., (1985)J. Engl. J. Med. 312:1217–1224.
Saynor, R., Verel, D., and Gillott, T. (1984)Atherosclerosis 50:3–10.
Thorngren, M., and Gustafson, A. (1981)Lancet 2:1190–1193.
Nagakaw, Y., Orimo, H., Harsawa, M., Morita, I., Yashiri, K., and Murota, S. (1983)Atherosclerosis 47:71–75.
Lorenz, R., Spengler, U., Drum, J., and Weber, P.C. (1983)Circulation 67:504–511.
Terano, T., Salmon, J.A., and Moncada, S. (1985)Adavances in Prostaglandin, Thromboxane, and Leukotriene Research 15:252–255.
Ackman, R.G. (1988)Chem. Ind. 7:139–145.
Hepburn, F.N., Exler, J., and Weihrauch, J.L. (1986)J. Am. Dietetic Ass. 86:788–793.
LePage, G., and Roy, C.C. (1986)J. Lipid Res. 27:114–117.
Kovacs, M.I.P., Anderson, W.E., and Ackman, R.G. (1979)J. Food Sci. 44:1299–1305.
Bankson, D.D., Russell, R.M., and Sadowski, J.A. (1986)Clin. Chem. 32:35–40.
Taylor, S.L., Lamden, M.P., and Tappel, A.L. (1976)Lipids 11:530–538.
Sobcommitte on the Tenth Edition of the RDA's, Food and Nutrition Board, Commission on Life Sciences National Research Council (NRC) (1990)Recomended Dietary Allowances 10th Edition, National Academy Press, Washington, D.C., pp. 79–82.
Davis, H.R., Bridenstine, R.T., Vesselinovitch, D., and Wissler, R.W. (1987)Arteriosclerosis 7:441–449.
Weiner, B.H., Ockene, I.S., Levine, P.H., Cuenoud, H.F., Fisher, M., Johnson, B.F., Daoud, A.S., Jarmolych, J., Hosmer, D., Johnson, M.H., Natale, A., Vaudreuil, C., and Hoogasian, J.J. (1986)N. Engl. J. Med. 315:841–846.
Exler, J., and Weihrauch, J.L. (1988)USDA 1HNIS PT-103.
Meydani, S.N., Shapiro, A.C., Meydani, M., Maculey, J.B., and Blumber, J.B. (1987)Lipids 22:345–350.
Shapiro, A.C., Meydani, S.N., Meydani, M., Morrow, F., Blumberg, J., Endres, S., and Dinarello, K.A. (1989) inHealth Effects of Fish and Fish Oils, (Chandra, R.L., ed.), pp. 537–546, Arts Biomedical Pub., Newfoundland.
Harris, W.S. (1989)J. Lipid Res. 30:785–807.
Mensink, R.P., and Katan, M.B. (1989)N. Engl. J. Med. 321:436–441.
Abbey, M., Clifton, P., Belling, B., and Nestel, P. (1990)Arteriosclerosis 10:85–94.
Schectman, G., Sushma, K., and Kissebah, A.H. (1990)Atherosclerosis 9:345–354.
Rosenberg, I.H., and Schaefer, E.J. (1988)N. Engl. J. Med. 318:1270–1271.
Grundy, S.M., (1986)N. Engl. J. Med. 314:745–748.
Bonanome, A., and Grundy, S.M. (1988)N. Engl. J. Med. 318:1244–1248.
Ginsberg, H.N., Barr, S.L., Gilbert, A., Karmally, W., Deckelbaum, R., Kaplan, K., Kamakrishnan, R., Holleren, S., Dell, R.B. (1990)N. Engl. J. Med. 322:574–579.
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Chee, K.M., Gong, J.X., Good Rees, D.M. et al. Fatty acid content of marine oil capsules. Lipids 25, 523–528 (1990). https://doi.org/10.1007/BF02537158
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DOI: https://doi.org/10.1007/BF02537158