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Gastric mucosal blood flow and acid secretion in conscious animals measured by heat clearance

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Summary

The heat-clearance technic has been used to assess the effect of histamine, gastrin pentapeptide, antihistamine, and vasopressin on gastric mucosal blood flow and acid secretion in conscious dogs before and after vagotomy. The results suggest that:

  1. 1.

    Mucosal flow is increased with an increase in acid output, but the two processes do not always increase in parallel. At submaximal stimulation secretion can increase without a further rise in mucosal flow.

  2. 2.

    An increase in flow does not necessarily cause an increase in acid output.

  3. 3.

    If flow is decreased sufficiently then basal or stimulated acid secretion cannot continue.

  4. 4.

    Vagotomy has no long-term effect on the ability of the gastric mucosal vasculature to respond to vasoactive agents.

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Author notes

  1. P. R. F. Bell M.B., Ch.B.

    Present address: , 501 Madison St., Denver, Colo

Authors and Affiliations

  1. From the Department of Surgery, Western Infirmary, and Wellcome Surgical Research Laboratory, Glasgow, Scotland

    P. R. F. Bell M.B., Ch.B. & T. Shelley M.Sc., Ph.D.

Authors
  1. P. R. F. Bell M.B., Ch.B.
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  2. T. Shelley M.Sc., Ph.D.
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Bell, P.R.F., Shelley, T. Gastric mucosal blood flow and acid secretion in conscious animals measured by heat clearance. Digest Dis Sci 13, 685–696 (1968). https://doi.org/10.1007/BF02232992

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  • DOI: https://doi.org/10.1007/BF02232992

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