Summary
Investigators reporting clinical studies of diazepam tend to be enthusiastic about its effectiveness in controlling anxiety, but two careful double-blind studies on hospitalized patients found diazepam relatively ineffective. This investigation covering an outpatient population of one hundred found that treatment with diazepam was not significantly superior to placebo. Moreover, diazepam treatment was also associated in some patients with the emergence of suicidal thoughts or tendencies and paranoid tendencies in others.
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Carter, C. H.: Diazepam in management of spasticity and related symptoms in brain-damaged patients. West. Med. 4, spec. Suppl. 54–60 (1963).
Cooper, D. C.: Comparative effects of diazepam, chlormezanone, and carisoprodol in musculoskeletal disorders. West. Med. 4, spec. Suppl. 34–39 (1963).
Cromwell, H. A.: Controlled evaluation of psychotherapeutic drug in internal medicine. Clin. Med. 70, 2239–2244 (1963).
Crossfield, R. M., and M. E. Soria: Parenteral use of diazepam. Dis. nerv. Syst. 23, 647–648 (1962).
Doshay, L. J.: Symposium on diazepam: introduction. West. Med. 4, spec. Suppl., 3–4 (1963).
Feldman, P. E.: An analysis of the efficacy of diazepam. J. Neuropsychiat. 3, Suppl. 1, 62–67 (1962).
Frank, J. D., E. H. Nash Jr., A. R. Stone, and S. D. Imber: Immediate and long-term symptomatic course of psychiatric outpatients. Amer. J. Psychiat. 120, 429–439 (1963).
Freedman, N., D. M. Engelhardt, D. Mann, R. Margolis, and S. London: Communication of body complaints and paranoid symptom change under conditions of phenothiazine treatment. J. pers. soc. Psychol. 1, 310–318 (1965).
Glick, B. S.: Effect of altered clinic conditions on reported change in anxiety. J. Neuropsychiat. 5, 291–296 (1964).
Gliedman, L. H., E. H. Nash Jr., S. D. Imber, A. R. Stone, and J. D. Frank: Reduction of symptoms by pharmacologically inert substances and by short-term psychotherapy. A.M.A. Arch. Neurol. Psychiat. 79, 345–351 (1958).
Hankoff, L. D., R. H. Gundlach, H. M. Paley, and L. Rudorfer: Diphenhydramine as an antidepressant: a negative finding. Dis. nerv. Syst. 25, 547 to 553 (1964).
—, L. Rudorfer, and H. M. Paley: A reference study of ataraxics: a two week double blind outpatient evaluation. J. new Drugs 2, 173–178 (1962).
Hare, H. P., Jr.: Comparison of diazepam, chlorpromazine and a placebo in psychiatric practice. J. new Drugs 3, 233–240 (1963).
Hollister, L. E., J. L. Bennett, I. Kimbell Jr., C. Savage, and J. E. Overall: Diazepam in newly admitted schizophrenics. Dis. nerv. Syst. 24, 746–749 (1963).
Kerry, R. J., and F. A. Jenner: A double blind crossover comparison of diazepam (Valium, Ro 5-2807) with chlordiazepoxide (Librium) in the treatment of neurotic anxiety. Psychopharmacologia (Berl.) 3, 302–306 (1962).
Love, J.: Diazepam in treatment of emotional disorders. Dis. nerv. Syst. 24, 674–677 (1963).
Merlis, S., W. J. Turner, and W. Krumholz: A double blind comparison of diazepam, chlordiazepoxide, and chlorpromazine in psychotic patients. J. Neuropsychiat. 3, Suppl. 1, 133–138 (1962).
Phelps, W. M.: Observation of a new drug in cerebral palsy athetoids. West. Med. 4, spec. Suppl. 5–10 (1963).
Pignataro, F. P.: Experience with chemotherapy in refractory psychiatric disorders. Amer. J. Psychiat. 119, 577–579 (1962).
Proctor, R. C.: The improved management of incapacitating anxiety states. J. Neuropsychiat. 3, Suppl. 1, 151–154 (1962).
Randall, L. O., G. A. Heise, W. Schallek, R. E. Bagdon, R. Banziger, A. Boris, R. A. Moe, and W. B. Abrams: Pharmacological and clinical studies on Valium (T. M.)—a new psychotherapeutic agent of the benzodiazepine class. Curr. ther. Res. 3, 405–425 (1961).
Sussex, J. N., P. A. Linton, and C. E. Herlihy: Anxiety and depression in “borderline” schizophrenic states — treatment with Valium, a Librium analog. Psychosomatics 2, 256 (1961).
Vilkin, M. I., and J. B. Lomas: Clinical experience with diazepam in general psychiatric practice. J. Neuropsychiat. 3, Suppl. 1, 139–144 (1963).
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This study was undertaken by the Psychopharmacology Research and Treatment Unit. It was supported in part by a grant from the U.S. Public Health Service (MH 05090).
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Gundlach, R., Engelhardt, D.M., Hankoff, L. et al. A double-blind outpatient study of diazepam (Valium) and placebo. Psychopharmacologia 9, 81–92 (1966). https://doi.org/10.1007/BF00404713
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DOI: https://doi.org/10.1007/BF00404713