A total of 44 rat saphenous nerves were isolated. A pair of stimulating electrodes was positioned distally (at the ankle) to evoke a compound action potential (CAP) which was recorded proximally (in the thigh) through another pair of electrodes. Bone cement was then placed adjacent to the nerve midway between the electrodes and changes in the CAP recorded over a 30-min period. Nerve conduction was completely blocked within 2 min of placing unset acrylic bone cement adjacent to the nerve. The experimental ionomeric cements (IC) also caused a reduction in the nerve conduction although this did not usually occur until the cement had been positioned adjacent to the nerve for over 10 min. Slow-setting IC blocked nerve conduction more quickly than fast-setting IC but there was no apparant difference between the effects of applying materials early or late in the setting reaction. Set ionomeric porous microimplant particles (lonogran®) had no effect on neural function.
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Loescher, A.R., Robinson, P.P. & Brook, I.M. The immediate effects of ionomeric and acrylic bone cements on peripheral nerve function. J Mater Sci: Mater Med 5, 551–556 (1994). https://doi.org/10.1007/BF00124888
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DOI: https://doi.org/10.1007/BF00124888