Skip to main content

Endogenous Endophthalmitis from the Prospective of Integration Medicine

  • Chapter
  • First Online:
Integrative Ophthalmology

Part of the book series: Advances in Visual Science and Eye Diseases ((AVSED,volume 3))

Abstract

Endophthalmitis is the acute suppurative inflammation in uvea and retina, with rapid onset, severe symptoms, and poor prognosis. Definite diagnosis and effective treatment on early stage play key roles in the prognosis. As endogenous endophthalmitis originates from suppurative inflammation in other parts of our body with hidden primary lesions, and is found less common in clinical practice, ophthalmologists might easily confuse it with uveitis caused by the immune disease, which not only causes a high misdiagnosis rate, but also delays the best opportunity for diagnosis and treatment. Endogenous endophthalmitis is a focus secondary to systemic infection, requiring ophthalmologists to strengthen the understanding of systemic infection and detailed history taking, to learn that whether the primary lesions exist or not? Where is the primary lesion? Which kind of pathogen causes the infection? How to apply the antibiotics? This section analyzes the cases of endogenous endophthalmitis in Tongren Hospital, and summarizes the experience in etiology, clinical manifestation, diagnosis points, treatment, prognosis, etc. of endogenous endophthalmitis. Ophthalmologists are supposed to take endogenous endophthalmitis from the perspective of integrative medicine, identify endogenous endophthalmitis through the history and pathogen examination, and clarify the cause and pathogens, and thus target the selection of antibiotics, taking the systemic inflammation control into account. Ophthalmologists should strengthen the understanding of endogenous endophthalmitis, make diagnosis at early stage and apply the effective drug timely, and improve the prognosis of endogenous endophthalmitis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Connell PP, O’Neill EC, Fabinyi D, et al. Endogenous endophthalmitis: 10-year experience at a tertiary referral centre. Eye (Lond). 2011;25(1):66–72.

    Article  CAS  Google Scholar 

  2. Jackson TL, Eykyn SJ, Graham EM, et al. Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol. 2003;48(4):403–23.

    Article  PubMed  Google Scholar 

  3. Chung KS, Kim YK, Song YG, et al. Clinical review of endogenous endophthalmitis in Korea: a 14-year review of culture positive cases of two large hospitals. Yonsei Med J. 2011;52(4):630–4.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Binder MI, Chua J, Kaiser PK, et al. Endogenous endophthalmitis: an 18-year review of culture-positive cases at a tertiary care center. Medicine (Baltimore). 2003;82(2):97–105.

    Article  Google Scholar 

  5. Lim HW, Shin JW, Cho HY, et al. Endogenous endophthalmitis in the Korean population: a six-year retrospective study. Retina. 2014;34(3):592–602.

    Article  PubMed  Google Scholar 

  6. Pinna A, Cara F, Zanetti S, et al. Endogenous Rhodotorula minuta and Candida albicans endophthalmitis in an injecting drug user. Br J Ophthalmol. 2001;85(6):759.

    Article  CAS  PubMed  Google Scholar 

  7. Chhablani J. Fungal endophthalmitis. Exp Rev Anti Infect Ther. 2011;9(12):1191–201.

    Article  Google Scholar 

  8. Schiedler V, Scott IU, Flynn HW. Culture-proven endogenous endophthalmitis clinical features and visual acuity outcomes. Am J ophthalmol. 2004;137(4):725–31.

    PubMed  Google Scholar 

  9. Chen KJ, Wu WC, Sun MH, et al. Endogenous fungal endophthalmitis: causative organisms, management strategies, and visual acuity outcomes. Am J Ophthalmol. 2012;154(1):213–4.

    Article  PubMed  Google Scholar 

  10. Arevalo JF, Jap A, Chee SP, et al. Endogenous endophthalmitis in the developing world. Int Ophthalmol Clin. 2010;50(2):173–87.

    Article  PubMed  Google Scholar 

  11. Sridhar J, Flynn HW Jr, Kuriyan AE, et al. Endogenous fungal endophthalmitis: risk factors, clinical features, and treatment outcomes in mold and yeast infections. J Ophthalmic Inflamm Infect. 2013;3(1):60.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kauffman CA, Vazquez JA, Sobel JD, et al. Prospective multicenter surveillance study of funguria in hospitalized patients. The National Institute for Allergy and Infectious Diseases Mycoses Study Group. Clin Infect Dis. 2000;30(1):14–8.

    Article  CAS  PubMed  Google Scholar 

  13. Congrong L, Shaohua P, Dong L, et al. A hospital acquired infection of deep fungus: a clinical investigation and drug resistance. Chin J Nosocomiol. 2002;12(7):485–7.

    Google Scholar 

  14. Pfaller MA, Messer SA, Hollis RJ, et al. Trends in species distribution and susceptibility to fluconazole among blood steam isolates of Candida species in the United states. Diagn Microbiol Infect Dis. 1999;33(4):217–22.

    Article  CAS  PubMed  Google Scholar 

  15. Leibovitch I, Lai T, Raymond G, et al. Endogenous endophthalmitis: a 13-year review at a tertiary hospital in South Australia. Scand J Infect Dis. 2005;37(3):184–9.

    Article  PubMed  Google Scholar 

  16. Wong JS, Chan TK, Lee HM. Endogenous bacterial endophthalmitis. An east Asian experience and a reappraisal of a severe ocular affliction. Ophthalmology. 2000;107(8):1483–91.

    Article  CAS  PubMed  Google Scholar 

  17. Peizeng Y. Clinical uveitis. Beijing: People’s Medical Publishing House; 2004. p. 677–8.

    Google Scholar 

  18. Cornut PL, Chiquet C. Endogenous bacterial endophthalmitis. J Fr Ophthalmol. 2011;34(1):51–7.

    Article  Google Scholar 

  19. Lee JH, Kim JS, Park YH. Diagnosis and treatment of postpartum Candida endophthalmitis. J Obstet Gynaecol Res. 2012;38(9):1220–2.

    Article  PubMed  Google Scholar 

  20. Tanaka M, Kobayashi Y, Takebayashi H, et al. Analysis of predisposing clinical and laboratory findings for the development of endogenous fungal endophthalmitis: a retrospective 12-year study of 79 eyes of 46 patients. Retina. 2001;21(3):203–9.

    Article  CAS  PubMed  Google Scholar 

  21. Okada AA, Johnson RP, Liles WC. Endogenous bacterial endophthalmitis. Report of a 10-year retrospective study. Ophthalmology. 1994;101(5):832–8.

    Article  CAS  PubMed  Google Scholar 

  22. Greenwald MJ, Wohl LG, Sell CH. Metastatic bacterial endophthalmitis: a contemporary reappraisal. Surv Ophthalmol. 1986;31(2):81–101.

    Article  CAS  PubMed  Google Scholar 

  23. Christmas NJ, Smiddy WE. Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers. 1996;27(12):1012–8.

    CAS  PubMed  Google Scholar 

  24. Gallis HA, Drew RH, Pickard WW. Amphotericin B: 30 years of clinical experience. Rev Infect Dis. 1990;12(2):308–29.

    Article  CAS  PubMed  Google Scholar 

  25. Akler ME, Vellend H, McNeely DM, et al. Use of fluconazole in the treatment of candidal endophthalmitis. Clin Infect Dis. 1995;20(3):657–64.

    Article  CAS  PubMed  Google Scholar 

  26. Riddell J 4th, Comer GM, Kauffman CA. Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents. Clin Infect Dis. 2011;52(5):648–53.

    Article  CAS  PubMed  Google Scholar 

  27. Penk A, Pittrow L. Status of fluconazole in the therapy of endogenous Candida endophthalmitis. Mycoses. 1998;2:41–4.

    Google Scholar 

  28. Michal W, Olena W, Wojciech O. Bilateral endogenous fungal endophthalmitis. Int Ophthalmol. 2014;34(2):321–5.

    Article  PubMed  Google Scholar 

  29. Shen X, Xu G. Vitrectomy for endogenous fungal endophthalmitis. Ocul Immunol Inflamm. 2009;17(3):148–52.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Wang, H., Wei, W., Shen, L., Hong, Y. (2020). Endogenous Endophthalmitis from the Prospective of Integration Medicine. In: Wang, N. (eds) Integrative Ophthalmology. Advances in Visual Science and Eye Diseases, vol 3. Springer, Singapore. https://doi.org/10.1007/978-981-13-7896-6_34

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-7896-6_34

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-7895-9

  • Online ISBN: 978-981-13-7896-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics