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Biodegradable Composite Scaffold for Bone Tissue Regeneration

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Biomedical Engineering and its Applications in Healthcare

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Abstract

At micro-architectural viewpoint, human bone is composed of polymer ceramic composite having similar mechanical characteristics that can be tailored by synthetic composite materials. To mimic the properties of bone, research on bone substituted analogous biomaterials was initiated by reinforcing active biomolecules within the matrices of biocompatible polymers to formulate suitable bone analogous. The major advantages of the composites over conventional homogeneous materials like metals, ceramics, and polymers are superior mechanical, biological, and other physical properties that can be matched with the requirements of particular applications. Modern technology has not been able to provide a suitable bone substitute that replaces autogenous bone. The availability and suitability of conventional autogenous or homogeneous prosthetic elements to repair severe bone trauma or large defects caused by various bone diseases are critically limited; as a result, profound interest concentrated on application of man-made polymeric composite materials as biodegradable scaffold, which would provide support and a symptomatic, long-term function within the body or in contact with body fluid. In tissue engineering, biodegradable scaffolds play a crucial role, where matrix degradation and tissue in growth are of immense phenomenon for decisive performance of tissue-scaffold system during regenerative process.

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  1. JIS College of Engineering, Kalyani, West Bengal, India

    Sandip Bag

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  1. Department of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya, India

    Sudip Paul

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Bag, S. (2019). Biodegradable Composite Scaffold for Bone Tissue Regeneration. In: Paul, S. (eds) Biomedical Engineering and its Applications in Healthcare. Springer, Singapore. https://doi.org/10.1007/978-981-13-3705-5_27

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