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Dietary Coumarins

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Book cover Handbook of Dietary Phytochemicals

Abstract

Dietary phytochemicals are bioactive components of plant-based foods (phyto-foods), e.g., fruits, vegetables, grains, and tea. Their regular and adequate intake may offer protection from major chronic diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases. Phyto-foods like apples, blueberries, broccoli, cherries, soybeans, and walnuts contain bioactive phytochemicals of various chemical classes, in addition to usual micronutrients and fibers. One of such major groups of phytochemicals found in plant-based food items are naturally occurring coumarins, which belong to the chemical class of 1-benzopyran derivatives. Plants from the families Apiaceae, Asteraceae, and Rutaceae are three major sources of naturally occurring coumarins. Some commonly consumed coumarin-containing phyto-foods include carrots, celery, parsnip, strawberries, citrus fruits, apricots, and cherries, as well as spices like cinnamon and fennels. This chapter presents a coverage primarily on most common coumarins that occur in food plants and their contributions to human health and wellbeing.

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References

  • Alizadeh MN, Rashidi M, Muhammadnejad A, Zanjani TM, Ziai SA (2018) Antitumor effects of umbelliprenin in a mouse model of colorectal cancer. Iran J Pharm Res 17:976–985

    CAS  Google Scholar 

  • An J, Yang H, Zhang Q, Liu CC, Zhao JJ, Zhang LL, Chen B (2016) Natural products for treatment of osteoporosis: the effects and mechanisms on promoting osteoblast-mediated bone formation. Life Sci 147:46–58

    Article  CAS  PubMed  Google Scholar 

  • Anesyan ET, Nersesyan ZM, Parkhomenko AY (2007) Chemical composition of the aboveground part of Coriandrum sativum. Khim-Farm Zh 41:30–34

    Google Scholar 

  • Anwar F, Al-Abbasi FA, Bhatt PC, Ahmad A, Sethi N, Kumar V (2015) Umbelliferone beta-D-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-kappa B. Toxicol Res 4:1308–1323

    Article  CAS  Google Scholar 

  • Awad AS, Al-Rifai AA, El-Meligy RM, Alafeefy AM, Zain ME (2015) New activities for isolated compounds from Convolvulus austro-aegyptiacus as anti-ulcerogenic, anti-helicobacter pylori and their mimic synthesis using bio-guided fractionation. Phytother Res 29:1311–1316

    Article  CAS  Google Scholar 

  • Baleni R, Bekker Z, Walubo A, Du Plessis JB (2015) Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol-induced hepatotoxicity after paracetamol overdose in rats. Toxicol Rep 2:677–684

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ballin NZ, Sorensen AT (2014) Coumarin content in cinnamon containing food products on the Danish market. Food Control 38:198–203

    Article  CAS  Google Scholar 

  • Bansal M, Singh N, Pal S, Dev I, Ansari KM (2018) Chemopreventive role of dietary phytochemicals in colorectal cancer. Adv Mol Toxicol 12:69–121

    Article  Google Scholar 

  • Bao YX, Meng XL, Liu FN, Wang F, Tang JH, Wang HY, Xie GH (2018) Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Mol Med Rep 17:4561–4566

    CAS  PubMed  Google Scholar 

  • Bianchi N, Borgatti M, Gambari R, Lampronti I (2009) Use of angelicin and of its structural analogues for the treatment of thalassemia. Official Gazette of the United States Patent and Trademark Office Patents, US patent number. US 07572827

    Google Scholar 

  • Boix-Vilanova J, Corral-Magana O, Martin-Santiago A, Escalas J (2018) Folliculotropic mycosis fungoides in a pediatric patient with response to psoralen-ultraviolet-a phototherapy. Photodermatol Photoimmunol Photomed. https://doi.org/10.1111/phpp.12414

    Article  Google Scholar 

  • Bonamonte D, Foti C, Lionetti N, Rigano L, Angelini G (2010) Photoallergic contact dermatitis to 8-methoxypsoralen in Ficus carica. Contact Dermatitis 62:343–348

    Article  CAS  PubMed  Google Scholar 

  • Brass D, Fouweather T, Stocken DD, Macdonald C, Wilkinson MJ, Lloyd J, Farr PM, Reynolds NJ, Hampton PJ (2018) An observer-blinded randomised controlled pilot trial comparing localized immersion psoralen-ultraviolet a with localized narrowband ultraviolet B for the treatment of palmar hand eczema. Br J Dermatol 179:63–71

    Article  CAS  PubMed  Google Scholar 

  • Budzisz E, Brzezinska E, Krajewska U, Rozalski M (2003) Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues. Eur J Med Chem 38:597–603

    Article  CAS  PubMed  Google Scholar 

  • Budzynska B, Skalicka-Wozniak K, Kruk-Slomka M, Wydrzynska-Kuzma M, Biala G (2016) In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone. Psychopharmacology 233:2289–2300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cai Y, Sun W, Zhang XX, Lin YD, Chen H, Li H (2018) Osthole prevents acetaminophen-induced liver injury in mice. Acta Pharmacol Sin 39:74–84

    Article  CAS  PubMed  Google Scholar 

  • Cao YJ, He X, Wang N, He LC (2013) Effects of imperatorin, the active component from radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K, 1C hypertensive rats. Phytomedicine 20:1048–1054

    Article  CAS  PubMed  Google Scholar 

  • Cao YJ, Liu JH, Wang QO, Liu MH, Cheng Y, Zhang XX, Lin TW, Zhu ZL (2017) Antidepressive-like effect of imperatorin from Angelica dahurica in prenatally stressed offspring through 5-hydroxytryptamine system. Neuroreport 28:426–433

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chan YY, Li CH, Shen YC, Wu TS (2010) Anti-inflammatory principles from the stem and root barks of Citrus medica. Chem Pharm Bull 58:61–65

    Article  CAS  Google Scholar 

  • Chang WC, Wu SC, Xu KD, Liao BC, Wu JF, Cheng AS (2015) Protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. Molecules 20:2786–2801

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chavez DSA, Frattani FS, Assafim M, de Almeida AP, Zingali RB, Costa SS (2011) Phenolic chemical composition of Petroselinum crispum extract and its effect on haemostasis. Nat Prod Commun 6:961–964

    Google Scholar 

  • Chen T, Guo QQ, Wang HM, Zhang HX, Wang CM, Zhang P, Meng SS, Li YM, Ji H, Yan TH (2015) Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-kappa B pathways in vivo and in vitro. Free Radic Res 49:1459–1468

    Article  CAS  PubMed  Google Scholar 

  • Chen YC, Zhang QF, Liu HZ, Lu CJ, Liang CL, Qiu FF, Han L, Dai ZH (2018a) Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells. Front Immunol 9:Article number: 2092. https://doi.org/10.3389/fimmu.2018.02092

  • Chen J-Y, Zhuang T-X, Chen J, Peng L (2018b) Effect of osthole on radiotherapy of transplanted human nasopharyngeal carcinoma in nude mice and relevant mechanism. Chin J Biol 31:479–484

    Google Scholar 

  • Chen WL, Li JJ, Sun ZP, Wu CY, Ma J, Wang JY, Liu S, Han XH (2018c) Comparative, pharmacokinetics of six coumarins in normal and breast cancer bone-metastatic mice after oral administration of Wenshen Zhuanggu formula. J Ethnopharmacol 224:36–44

    Article  CAS  PubMed  Google Scholar 

  • Chen G, Xu Q, Dai M, Liu X (2019) Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-kappa B and JNK signaling pathways. Biochem Biophys Res Commun 509:329–334

    Article  CAS  PubMed  Google Scholar 

  • Cheng L, Wang Z, Jiang C, Zhang S (2013) Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats. J Clin Otorhinolaryngol Head Neck Surg 27:1310–1312

    CAS  Google Scholar 

  • Cherng J-M, Chiang W, Chiang L-C (2008) Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chem 106:944–950

    Article  CAS  Google Scholar 

  • Chiang CY, Lee CC, Fan CK, Huang HM, Chiang BL, Lee YL (2017) Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function. Cell Mol Immunol 14:935–947

    Article  CAS  PubMed Central  Google Scholar 

  • Cho H-J, Jeong S-G, Park J-E, Han J-A, Kang H-R, Lee D, Song MJ (2013) Antiviral activity of angelicin against gamma herpes viruses. Antivir Res 100:75–83

    Article  CAS  PubMed  Google Scholar 

  • Choi WS, Jang DY, Nam SW, Park BS, Lee HS, Lee SE (2012) Antiulcerogenic activity of Scoparone on HCl/ethanol-induced gastritis in rats. J Korean Soc Appl Biol Chem 55:159–163

    Article  CAS  Google Scholar 

  • Choi RY, Ham JR, Lee MK (2016) Esculetin prevents non-alcoholic fatty liver in diabetic mice fed high-fat diet. Chem Biol Interact 260:13–21

    Article  CAS  PubMed  Google Scholar 

  • Choi RY, Ham JR, Lee HI, Cho HW, Choi MS, Park SK, Lee J, Kim MJ, Seo KI, Lee MK (2017) Scopoletin supplementation ameliorates steatosis and inflammation in diabetic mice. Phytother Res 31:1795–1804

    Article  CAS  PubMed  Google Scholar 

  • Chowdhury AA, Gawali NB, Shinde P, Munshi R (2018) Imperatorin ameliorates lipopolysaccharide induced memory deficit by mitigating proinflammatory cytokines, oxidative stress and modulating brain-derived neurotropic factor. Cytokine 110:78–86

    Article  CAS  PubMed  Google Scholar 

  • Detsi A, Kontogiorgis C, Hadjipavlou-Litina D (2017) Coumarin derivatives: an updated patent review (2015–2016). Expert Opin Ther Pat 27:1201–1226

    Article  CAS  PubMed  Google Scholar 

  • Dhalwal K, Shinde VM, Mahadik KR (2008) Efficient and sensitive method for quantitative determination and validation of umbelliferone, carvone and myristicin in Anethum graveolens and Carum carvi seed. Chromatographia 67:163–167

    Article  CAS  Google Scholar 

  • Dillard CJ, German JB (2000) Phytochemicals: nutraceuticals and human health. J Sci Food Agric 80:1744–1756

    Article  CAS  Google Scholar 

  • Dong L, Xu WW, Li H, Bi KH (2018) In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediate apoptosis, cell cycle arrest, and inhibition of cancer cell migration. Oncol Rep 39:597–602

    CAS  PubMed  Google Scholar 

  • Dou C, Chen Y, Ding N, Li N, Jiang H, Zhao C, Kang F, Cao Z, Quan H, Luo F, Xu J, Dong S (2016) Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis. Osteoporos Int 27:2335–2344

    Article  CAS  PubMed  Google Scholar 

  • Dugrand A, Olry A, Duval T, Hehn A, Froelicher Y, Bourgaud F (2013) Coumarin and furanocoumarin quantitation in Citrus peel via ultraperformance liquid chromatography coupled with mass spectrometry (UPLC-MS). J Agric Food Chem 61:10677–10684

    Article  CAS  PubMed  Google Scholar 

  • Fan Y, Li Z, Chi T-Y, Zhao J-S, Yu X-H (2006) Inhibitory effect of Scoparone on inflammatory mediator in asthmatic Guinea pig model. J China Med Univ 35:132–133

    CAS  Google Scholar 

  • Feng LL, Sun Y, Song PP, Xu LS, Wu XX, Wu XF, Shen Y, Sun Y, Kong LD, Wu XD, Xu Q (2019) Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. Br J Pharmacol 176:317–333

    Article  CAS  PubMed  Google Scholar 

  • Fu B, Su Y, Ma X, Mu CY, Yu FS (2018) Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts. J Pharmacol Sci 137:110–115

    Article  CAS  PubMed  Google Scholar 

  • Fuhr U (1998) Drug interactions with grapefruit juice. Drug Saf 18:251–272

    Article  CAS  PubMed  Google Scholar 

  • Gan JX, Qian WC, Lin S (2018) Umbelliferone alleviates myocardial ischemia: the role of inflammation and apoptosis. Inflammation 41:464–473

    Article  CAS  PubMed  Google Scholar 

  • Gao XG, Wang CY, Ning CQ, Liu KK, Wang XY, Liu ZH, Sun HJ, Ma XD, Sun PY, Meng Q (2018) Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor. Food Funct 9:2684–2694

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Argaez AN, Apan TOR, Delgado HP, Velazquez G, Martinez-Vazquez M (2000) Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med 66:279–281

    Article  CAS  PubMed  Google Scholar 

  • Garg SK, Gupta SR, Sharma ND (1980) Celerin, a new coumarin from Apium graveolens. Planta Med 38:186–188

    Article  CAS  Google Scholar 

  • Garud MS, Kulkarni YA (2017) Attenuation of renal damage in type I diabetic rats by umbelliferone – a coumarin derivative. Pharmacol Rep 69:1263–1269

    Article  CAS  PubMed  Google Scholar 

  • Ge L, Cui Y, Cheng K, Han J (2018) Isopsoralen enhanced osteogenesis by targeting AhR/Era. Molecules 23:2600. https://doi.org/10.3390/molecules23102600

    Article  CAS  PubMed Central  Google Scholar 

  • Germoush MO, Othman SI, Al-Qaraawi MA, Al-Harbi HM, Hussein OE, Al-Basher G, Alotaibi MF, Elgebaly HA, Sandhu MA, Allam AA, Mahmoud AM (2018) Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats. Biomed Pharmacother 102:392–402

    Article  CAS  PubMed  Google Scholar 

  • Ghanbarabadi M, Iranshahi M, Amoueian S, Mehri S, Motamedshariaty VS, Mohajeri SA (2016) Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: experimental study and histopathological evaluation. Neurosci Lett 623:13–21

    Article  CAS  PubMed  Google Scholar 

  • Ham JR, Lee HI, Choi RY, Sim MO, Choi MS, Kwon EY, Yun KW, Kim MJ, Lee MK (2016) Anti-obesity and anti-hepatosteatosis effects of dietary scopoletin in high-fat diet fed mice. J Funct Foods 25:433–446

    Article  CAS  Google Scholar 

  • Han HS, Jeon H, Kang SC (2018) Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice. Heliyon 4:Article Number: e00577. https://doi.org/10.1016/j.heliyon.2018.e00577

    Article  Google Scholar 

  • Hashemzaei M, SadeghiBonjar MA, Tabrizian K, Iranshahi M, Iranshahi M, Iranshahy M, Rezaee R (2015) Evaluation of the analgesic effect of umbelliprenin and umbelliprenin-morphine co-administration on the acute, chronic and neuropathic pain. Indian J Pharm Educ Res 49:121–125

    Article  CAS  Google Scholar 

  • Hassanein EHM, Mohamed WR, Shalkami AGS, Khalaf MM, Hemeida RAM (2018) Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P(38)MAPK/NF-kappa B, and apoptosis signaling pathways. Food Chem Toxicol 116:152–160

    Article  CAS  PubMed  Google Scholar 

  • He W, Chen WW, Zhou YM, Tian YT, Liao F (2013) Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. Cell Mol Neurobiol 33:715–722

    Article  CAS  PubMed  Google Scholar 

  • He GY, Troberg J, Lv X, Xia YL, Zhu LL, Ning J, Gem GB, Finel M, Yang L (2018) Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation. Xenobiotica 48:109–116

    Article  CAS  PubMed  Google Scholar 

  • Huang K, Wu GF, Zhou J, Peng SM (2018) Combination therapy with BMP-2 and psoralen enhances fracture healing in ovariectomized mice. Exp Ther Med 16:1655–1662

    PubMed  PubMed Central  Google Scholar 

  • Hung WL, Suh JH, Wang Y (2017) Chemistry and health effects of furanocoumarins in grapefruit. J Food Drug Anal 25:71–83

    Article  CAS  PubMed  Google Scholar 

  • Igase M, Okadam Y, Igase K, Ochi H, Okuyama S, Furukawa Y, Ohyahi Y (2018) Auraptene in the peels of Citrus kawachiensis (kawachibankan) contributes to the preservation of cognitive function: a randomized, placebo-controlled, double-blind study in healthy volunteers. J Prev Alzheimers Dis 5:197–201

    CAS  PubMed  Google Scholar 

  • Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H (2009) Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin in vivo. Eur J Cancer Prev 18:412–415

    Article  CAS  PubMed  Google Scholar 

  • Iyer D, Patil UK (2014) Evaluation of antihyperlipidemic and antitumour activities of isolated coumarins from Salvadora indica. Pharm Biol 52:78–85

    Article  CAS  PubMed  Google Scholar 

  • Iyer D, Patil UK (2018) Assessment of antihyperlipidemic and antitumor effect of isolated active phytoconstituents from Apium graveolens L. through bioassay-guided procedures. J Diet Suppl 1–4. https://doi.org/10.1080/19390211.2018.1448921

    Article  PubMed  CAS  Google Scholar 

  • Jagadeesh GS, Meeran MFN, Selvaraj P (2016) Protective effects of 7-hydroxycoumarin on dyslipidemia and cardiac hypertrophy in isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol 30:120–127

    Article  CAS  PubMed  Google Scholar 

  • Jang Y, Han J, Kim SJ, Kim J, Lee MJ, Jeong S, Ryu MJ, Seo KS, Choi SY, Shong M, Lim K, Heo JY, Kweon GR (2015) Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1a degradation. Oncotarget 6:38127–38138

    Article  PubMed  PubMed Central  Google Scholar 

  • Jang JH, Park JE, Han JS (2018) Scopoletin inhibits alpha-glucosidase in vitro and alleviates postprandial hyperglycemia in mice with diabetes. Eur J Pharmacol 834:152–156

    Article  CAS  PubMed  Google Scholar 

  • Jeong NH, Yan EJ, Jin M, Lee JY, Choi YA, Park PH, Lee SR, Kim SU, Shin TY, Kwon TK, Jang YH, Song KS, Kim s H (2018) Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines. Int Immunopharmacol 59:209–216

    Article  CAS  PubMed  Google Scholar 

  • Jin YY, Qian JC, Ju X, Bao XD, Li L, Zheng SQ, Chen X, Xiao ZX, Chen XM, Zhu WW, Li WX, Wu WC, Liang G (2018) Osthole protects against acute lung injury by suppressing NF-kappa B-dependent inflammation. Mediat Inflamm. Article number: 4934592. https://doi.org/10.1155/2018/4934592

    Article  CAS  Google Scholar 

  • Kadakol A, Malek V, Goru SK, Pandey A, Gaikwad AB (2017a) Telmisartan and esculetin combination ameliorates type 2 diabetic cardiomyopathy by reversal of H3, H2A, and H2B histone modifications. Indian J Pharmacol 49:348–356

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kadakol A, Malek V, Goru SK, Pandey A, Sharma N, Gaikwad AB (2017b) Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination. J Funct Foods 35:256–266

    Article  CAS  Google Scholar 

  • Kalaivanan K, Emayavaramban P, Sreeja S, Kalivarathan J, Venkatraman AC (2018a) Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity. Cell Stress Chaperones 23:857–869

    Article  CAS  Google Scholar 

  • Kalaivanan K, Chandrasekaran SP, Nanda D, Ramachandran V, Venkatraman AC (2018b) Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK. Mol Cell Biochem. https://doi.org/10.1007/s11010-018-3432-7

    Article  PubMed  CAS  Google Scholar 

  • Kang JW, Kim DW, Choi JS, Kim YS, Lee SM (2013) Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice. Food Chem Toxicol 57:132–139

    Article  CAS  PubMed  Google Scholar 

  • Kang KS, Lee W, Jung Y, Lee JH, Lee S, Eom DW, Jeon Y, Yoo HH, Jin MJ, Song KI, Kim WJ, Ham J, Kim HJ, Kim SN (2014) Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice. J Agric Food Chem 62:2069–2076

    Article  CAS  PubMed  Google Scholar 

  • Khaghanzadeh N, Samiei A, Ramezani M, Mojtahedi Z, Hosseinzadeh M, Ghaderi A (2014) Umbelliprenin induced production of IFN-gamma and TNF-alpha, and reduced IL-10, IL-4, Foxp3 and TGF-beta in a mouse model of lung cancer. Immunopharmacol Immunotoxicol 36:25–32

    Article  CAS  PubMed  Google Scholar 

  • Khaghanzadeh N, Samiei A, Mojtahedi Z, Ramezani M, Hosseinzadeh M, Ghaderi A (2017) Umbelliprenin induced both anti-inflammatory and regulatory cytokines in C57/BL6 mice. Iran J Basic Med Sci 20:829–834

    PubMed  PubMed Central  Google Scholar 

  • Khairy H, Saleh H, Badr AM, Marie MAS (2018) Therapeutic efficacy of osthole against dinitrobenzene sulphonic acid induced-colitis in rats. Biomed Pharmacother 100:42–51

    Article  CAS  PubMed  Google Scholar 

  • Kim MJ, Sim MO, Lee HI, Ham JR, Seo KI, Lee MK (2014) Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPAR alpha, and SREBP-1c in rats. Alcohol 48:707–715

    Article  CAS  PubMed  Google Scholar 

  • Kim YR, Park BK, Kim YH, Shim I, Kang IC, Lee MY (2018a) Antidepressant effect of Fraxinus rhynchophylla Hance extract in a mouse model of chronic stress-induced depression. Biomed Res Int. Article number: 8249563. https://doi.org/10.1155/2018/8249563

    Google Scholar 

  • Kim WK, Byun WS, Chung HJ, Oh J, Park HJ, Choi JS, Lee SK (2018b) Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. Biochem Pharmacol 152:71–83

    Article  CAS  PubMed  Google Scholar 

  • Kimura Y, Sumiyoshi M, Sakanak M, Taniguchi M, Baba K (2013) In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furanocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol 89:1216–1225

    Article  CAS  PubMed  Google Scholar 

  • Kleiner HE, Vulimiri SV, Starost MF, Reed MJ, Di Giovanni J (2002) Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice. Carcinogenesis 23:1667–1675

    Article  CAS  PubMed  Google Scholar 

  • Ko JH, Nam D, Um JY, Jung SH, Ahn KS (2018) Bergamottin inhibits adipogenesis in 3T3-L1 cells and weight regulation in diet-induced obese mice. Am J Chin Med 46:601–615

    Article  CAS  PubMed  Google Scholar 

  • Krushna GS, Shivaranjani VL, Umamaheswari J, Srinivasulu C, Hussain SA, Kareem MA, Reddy VD, Ali D, Lokhande KB, Swamy KV, Kodidhela LD (2017) In vivo and molecular docking studies whole extract and phytocompounds of Aegle marmelos fruit protective effects against isoproterenol-induced myocardial infraction in rats. Biomed Pharmacother 91:880–889

    Article  CAS  PubMed  Google Scholar 

  • Krzyzanowska J, Czubacka A, Oleszek W (2010) Dietary phytochemicals and human health. Adv Exp Med Biol 698:74–98

    Article  CAS  PubMed  Google Scholar 

  • Kumatia EK, Annan K, Dickson RA, Mensah AY, Amponash IK, Appiah AA, Tung NH, Edoh DA, Habtemariam S (2017) Antiinflammatory and analgesic effects in rodent models of ethanol extract of Clausena anisata roots and their chemical constituents. Nat Prod Commun 12:67–72

    PubMed  Google Scholar 

  • Lacy A, O’Kennedy R (2004) Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Curr Pharm Des 10:3797–3811

    Article  CAS  PubMed  Google Scholar 

  • Lagunas-Herrera H, Tortoriello J, Herrera-Ruiz M, Martinez-Henandez GB, Zamilpa A, Santamaria LA, Lorenzana MG, Lombardo-Earl G, Jumenez-Ferrer E (2019) Acute and chronic antihypertensive effect of fractions, tiliroside and scopoletin from Malva parviflora. Biol Pharm Bull 42:18–25

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Yang J, Jeon J, Jeong HS, Lee J, Sung J (2018) Hepatoprotective effect of esculetin on ethanol-induced liver injury in human HepG2 cells and C57BL/6J mice. J Funct Foods 40:536–543

    Article  CAS  Google Scholar 

  • Leema G, Tamizhselvi R (2018) Protective effect of Scopoletin against cerulein-induced acute pancreatitis and associated lung injury in mice. Pancreas 47:577–585

    Article  CAS  PubMed  Google Scholar 

  • Li D, Wu L (2017) Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. Exp Ther Med 14:874–880

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li WF, Wang Y, Wang XM, He ZH, Liu F, Zhi WB, Zhang HL, Niu XF (2016a) Esculin attenuates endotoxin shock induced by lipopolysaccharide in mouse and NO production in vitro through inhibition of NF-kappa B activation. Eur J Pharmacol 791:726–734

    Article  CAS  PubMed  Google Scholar 

  • Li XJ, Zhu Z, Han SL, Zhang ZL (2016b) Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-kappa B signaling pathways in osteoprotegerin knockout mice. Int J Mol Med 38:1661–1672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Li XF, Li ZK, Zhang L, Liu YG, Ding H, Yin SY (2017a) Isofraxidin, a coumarin component improves high-fat diet induced hepatic lipid homeostasis disorder and macrophage inflammation in mice. Food Funct 8:2886–2896

    Article  CAS  PubMed  Google Scholar 

  • Li XM, Yang Q, Li XB, Cheng Q, Zhang K, Han J, Zhao JN, Liu G, Zhao MG (2017b) Estrogen-like neuroprotection of isopsoralen against spinal cord injury through estrogen receptor ER alpha. Metab Brian Dis 32:259–265

    Article  CAS  Google Scholar 

  • Li WF, Wang Y, Wang XM, Zhang HL, He ZH, Zhi WB, Liu F, Niu XF (2017c) Gastroprotective effect of esculin on ethanol-induced lesion in mice. Fundam Clin Pharmacol 31:174–184

    Article  CAS  PubMed  Google Scholar 

  • Li SH, Gao P, Wang LT, Yan YH, Xia Y, Song J, Li HY, Yang JX (2017d) Osthole stimulated neural stem cells differentiation into neurons in an Alzheimer’s disease cell model via upregulation of microRNA-9 and rescued the functional impairment of hippocampal neurons in APP/PS1 transgenic mice. Front Neurosci. Article number: 340. https://doi.org/10.3389/fnins.2017.00340

  • Li FM, Li QH, Huang XQ, Wang YT, Ge CM, Qi Y, Guo W, Sun HT (2017e) Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-kappa B-mitogen-activated protein kinase signalling. Exp Ther Med 14:2385–2391

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li YL, Li YQ, Shi FG, Wang LN, Li LS, Yang DL (2018a) Osthole attenuates right ventricular remodeling via decreased myocardial apoptosis and inflammation in monocrotaline-induced rats. Eur J Pharmacol 818:525–533

    Article  CAS  PubMed  Google Scholar 

  • Li XT, Yu CB, Hu Y, Xia XY, Liao Y, Zhang J, Chen HW, Lu WL, Zhou W, Song ZC (2018b) New application of psoralen and angelicin on periodontitis with anti-bacterial, anti-inflammatory and osteogenesis effects. Front Cell Infec Microbiol 8:Article number: 178. https://doi.org/10.3389/fcimb.2018.00178

    Article  CAS  Google Scholar 

  • Li H, Meng D, Zhang X, Yuan D (2019) Effect of psoralen on the expression of PPARgamma, osteocalcin, and trabecular bone area in rabbits with steroid-induced avascular necrosis of the femoral head. J Orthop Surg Res 14:11 pages. https://doi.org/10.1186/s13018-018-1054-0

    Article  Google Scholar 

  • Lima V, Silva CB, Mafezoli J, Bezerra MM, Moraes MO, Mourao GSMM, Silva JN, Oliveira MCF (2006) Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia 77:574–578

    Article  CAS  PubMed  Google Scholar 

  • Lin QC, Wang WD, Li X, Lun JH, Shao TG (2017) Ameliorative effect of esculetin against streptozotocin-induced experimental dementia via activation of Nrf2/HO-1 axis and suppression of NF-kappa B. Lat Am J Pharm 36:399–407

    CAS  Google Scholar 

  • Liu X, Zhao XX (2017) Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-beta/Smad signaling pathway. Biomed Pharmacother 93:57–61

    Article  CAS  PubMed  Google Scholar 

  • Liu A, Shen Y, Du Y, Chen J, Pei F, Fu W, Qiao J (2018a) Esculin prevents lipopolysaccharide/D-galactosamine-induced acute liver injury in mice. Microb Pathog 125:418–422

    Article  CAS  PubMed  Google Scholar 

  • Liu MJ, Wang RH, Li Y, Bai D, Pan JH, Liu H, Wang SJ, Wu JY, Sun G, Miao Q, Ju DH, Liu LM (2018b) Effect of esculetin on bone metabolism in overiectomized rats. J Tradit Med 38:896–903

    Article  Google Scholar 

  • Liu JC, Zhou L, Wang F, Cheng ZQ, Rong C (2018c) Osthole decreases collagen I/III contents and their ratio in TGF-beta 1-overexpressed mouse cardiac fibroblasts through regulating the TGF-beta/Smad signaling pathway. Chin J Nat Prod 16:321–329

    Google Scholar 

  • Liu MJ, Zhang GH, Zheng CG, Song M, Liu FL, Hunag XT, Bai SS, Huang XA, Lin CZ, Zhu CC, Hu YJ, Mi SQ, Liu CH (2018d) Activating pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice. Br J Pharmacol 175:3563–3580

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Long HY (2016) Esculetin attenuates th2 and th17 responses in an ovalbumin-induced asthmatic mouse model. Inflammation 39:735–743

    Article  CAS  Google Scholar 

  • Lu HH, Zhang LH, Liu DH, Tang PF, Song FX (2014) Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci 14:641–647

    Article  PubMed  PubMed Central  Google Scholar 

  • Luo F, Zhou R, Lei H, Mou Y, Zhang P, Sun Y, Chen T, He L, Yan TH (2016) Umbelliferone attenuates lipopolysaccharide-induced acute lung injury linked with regulation of TLRs-MyD88 and RIP140/NF-kappa B signaling pathways. RSC Adv 6:97503–97511

    Article  CAS  Google Scholar 

  • Luo HB, Fan ZK, Xiang DK, Jiang ZW, Zhang WB, Gao LF, Feng C (2018) The protective effect of umbelliferone ameliorates myocardial injury following ischemia-reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-gamma. Mol Med Rep 17:3404–3410

    CAS  PubMed  Google Scholar 

  • Luszczki JJ, Andres-Mach M, Glensk M, Skalicka-Wosniak K (2010) Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study. Pharmacol Rep 62:1231–1236

    Article  CAS  PubMed  Google Scholar 

  • Mahmoud AM, Germoush MO, Alotaibi MF, Hussein OE (2017) Possible involvement of Nrf2 and PPAR gamma up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity. Biomed Pharmacother 86:297–306

    Article  CAS  PubMed  Google Scholar 

  • Majumdar B, De A, Ghosh S, Sil A, Sarda A, Lahiri K, Chatterjee G, Das S (2018) “Turban PUVAsol:” a simple, novel, effective, and safe treatment option for advanced and refractory cases of alopecia areata. Int J Trichol 10:124–128

    Article  Google Scholar 

  • Malik J, Karan M, Vasisht K (2016) Attenuating effect of bioactive coumarins from Convolvulus pluricaulis on scopolamine-induced amnesia in mice. Nat Prod Res 30:578–582

    Article  CAS  PubMed  Google Scholar 

  • Martin-Aragon S, Villar A, Benedi J (2016) Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status. Prog Neuro-Psychopharmacol Biol Psychiatry 65. https://doi.org/10.1016/j.pnpbp.2015.08.007

    Article  PubMed  CAS  Google Scholar 

  • Mateeva V, Etugov D, Mateev G (2018) Efficacy of systemic PUVA (psoralen plus ultraviolet light-a) in Bulgarian patients with mycosis fungoides. C R Acad Bulgare Sci 71:1549–1556

    Google Scholar 

  • Melough MM, Cho E, Chun OK (2018) Furocoumarins: a review of biochemical activities, dietary sources and intake, and potential health risks. Food Chem Toxicol 113:99–107

    Article  CAS  PubMed  Google Scholar 

  • Miyake Y, Murakami A, Sugiyama Y, Isobe M, Koshimizu K, Ohigashi H (1999) Identification of coumarins from lemon fruit (Citrus limon) as inhibitors of in vitro tumor promotion and superoxide and nitric oxide generation. J Agric Food Chem 47:3151–3157

    Article  CAS  PubMed  Google Scholar 

  • Miyazawa M, Tougo H, Ishihara M (2001) Inhibition of acetylcholinesterase activity by essential oil from Citrus paradisi. Nat Prod Lett 15:205–210

    Article  CAS  PubMed  Google Scholar 

  • Mohamed MR, Emam MA, Hassan NS, Mogadem AI (2014) Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression. Environ Toxicol Pharmacol 38:531–541

    Article  CAS  PubMed  Google Scholar 

  • Murakami A, Kuki W, Takahashi Y, Yonei H, Nakamura Y, Koshimizu K (1997) Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes. Jpn J Cancer Res 88:443–452

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naaz F, Abdin MZ, Javed S (2014) Protective effect of esculin against prooxidant aflatoxin B-1-induced nephrotoxicity in mice. Mycotoxin Res 30:25–32

    Article  CAS  PubMed  Google Scholar 

  • Nagao K, Yamano N, Shirouchui B, Inoue N, Murakami S, Sasaki T, Yanagita T (2010) Effects of Citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo. J Agric Food Chem 58:9028–9032

    Article  CAS  PubMed  Google Scholar 

  • Najda A, Dyduch J, Swica K, Kaplan M, Paplinski R, Sachadyn-Krol M, Klimek K (2015) Identification and profile of furanocoumarins from the ribbed celery (Apium graveolens L Var. Dulce Mill/Pers.). Food Sci Technol Res 21:67–75

    Article  CAS  Google Scholar 

  • Naowaboot J, Somparn N, Saentaweesuk S, Pannangpetch P (2015) Improves an impaired glucose and lipid metabolism in high-fat diet/streptozotocin-induced type 2 diabetic rats. Phytother Res 29:1388–1395

    Article  CAS  PubMed  Google Scholar 

  • Niu XF, Xing W, Li WF, Fan T, Hu H, Li YM (2012) Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-alpha production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway. Int Immunopharmacol 14:164–171

    Article  CAS  PubMed  Google Scholar 

  • Niu N, Li BL, Hu Y, Li XB, Li J, Zhang HQ (2014) Protective effects of scoparone against lipopolysaccharide-induced acute lung injury. Int Immunol 23:127–133

    CAS  Google Scholar 

  • Niu XF, Wang Y, Li WF, Zhang HL, Wang XM, Mu QL, He ZH, Yao H (2015a) Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-alpha and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway. Int Immunopathol 29:779–786

    CAS  Google Scholar 

  • Niu XF, Wang Y, Li WF, Mu QL, Li HN, Yao H, Zhang HL (2015b) Protective effects of isofraxidin against lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol 24:432–439

    Article  CAS  PubMed  Google Scholar 

  • Obidoa O, Obasi SC (1991) Coumarin compounds in cassava diets: 2 health implications of scopoletin in gari. Plant Foods Hum Nutr 41:283–289

    Article  CAS  PubMed  Google Scholar 

  • Oketch-Rabah H, Mwangia J, Lisgartenb J, Mberuc E (2000) A new antiplasmodial coumarin from Toddalia asiatica roots. Fitoterapia 71:636–640

    Article  CAS  PubMed  Google Scholar 

  • Okuyama S, Semba T, Toyoda N, Epifano F, Genovese S, Fiorito S, Taddeo VA, Sawamoto A, Nakajima M, Furukawa Y (2016) Auraptene and other prenyloxyphenylpropanoids suppress microglial activation and dopaminergic neuronal cell death in a lipopolysaccharide-induced model of Parkinson’s disease. Int J Mol Sci 17:Article number: 1716. https://doi.org/10.3390/ijms17101716

    Article  CAS  Google Scholar 

  • Okuyama S, Nakashima T, Nakamura K, Shinoka W, Kotani M, Sawamoto A, Nakajima M, Furukawa Y (2018) Inhibitory effects of auraptene and naringin on astroglial activation, tau hyperphosphorylation, and suppression of neurogenesis in the hippocampus of streptozotocin-induced hyperglycemic mice. Antioxidants 7:Article number: 109. https://doi.org/10.3390/antiox7080109

    Article  CAS  Google Scholar 

  • Osman WNW, Lau SF, Mohamed S (2017) Scopoletin-standardiuzed Morinda Elliptica leaf extract supressed inflammation and cartilage degredation to alleviate osteoarthritis: a preclinical study. Phytother Res 31:1954–1961

    Article  CAS  Google Scholar 

  • Ouyang JY, Jiang HJ, Fang H, Cui WB, Cai DZ (2017) Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin 1 signaling. Mol Med Rep 16:9636–9644

    Article  CAS  PubMed  Google Scholar 

  • Ozcelik B, Kusmenoglu S, Turkoz S, Abbasoglu U (2004) Antimicrobial activities of plantys from the Apiaceae. Pharm Biol 42:526–528

    Article  Google Scholar 

  • Pan R, Dai Y, Gao XH, Xia YF (2009) Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis. Int Immunopharmacol 9:859–869

    Article  CAS  PubMed  Google Scholar 

  • Pandey A, Raj P, Goru SK, Kadakol A, Malek V, Sharma N, Gaikwad AB (2017) Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway. Pharmacol Rep 69:666–672

    Article  CAS  PubMed  Google Scholar 

  • Pandy V, Vijeepallam K (2017) Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models. Exp Anim 66:417–423

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patil JR, Jayaprakasha GK, Kim J, Murthy KNC, Chetti MB, Nam SY, Patil BS (2013) 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med 79:219–226

    Article  CAS  PubMed  Google Scholar 

  • Pattanayak SP, Bose P, Sunita P, Siddique MUM, Lapenna A (2018) Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways. Biomed Pharmacother 108:297–308

    Article  CAS  PubMed  Google Scholar 

  • Peterson S, Lampe JW, Bannler TK, Gross-Steinmeyer K, Eaton DL (2006) Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B-1. Food Chem Toxicol 44:1474–1484

    Article  CAS  PubMed  Google Scholar 

  • Prince M, Li Y, Childers A, Ltoh K, Yamamoto M, Kleiner HE (2009) Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. Toxicol Lett 185:180–186

    Article  CAS  PubMed  Google Scholar 

  • Probst YC, Guan VX, Kent K (2017) Dietary phytochemical intake from foods and health outcomes: a systematic review protocol and preliminary scoping. BMJ Open 7:e013337

    Article  PubMed  PubMed Central  Google Scholar 

  • Qi SP, Yu JC (2016) Protective effect of esculin in hyperoxic lung injury in neonatal rats. Lat Am J Pharm 35:1177–1181

    CAS  Google Scholar 

  • Qin TT, Fang F, Song MT, Li RP, Ma ZQ, Ma SP (2017) Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway. Behav Brain Res 317:147–156

    Article  CAS  PubMed  Google Scholar 

  • Rashidi M, Khalilnezhad A, Amani D, Jamshidi H, Muhammadnejad A, Bazi A, Ziai SA (2018) Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice. J Cell Physiol 233:8908–8918

    Article  CAS  PubMed  Google Scholar 

  • Rauf A, Khan R, Khan H, Pervez S, Pirzada AS (2014) In vivo antinociceptive and anti-inflammatory activities of umbelliferone isolated from Potentilla evestita. Nat Prod Res 28:1371–1374

    Article  CAS  PubMed  Google Scholar 

  • Razavi BM, Arasteh E, Imenshahidi M, Iranshahi M (2015) Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration. Iran J Basic Med Sci 18:153–158

    PubMed  PubMed Central  Google Scholar 

  • Rouaiguia-Bouakkaz S, Amira-Guebailia H, Riviere C, Delaunay JC, Waffo-Teguo P, Merillon JM (2013) Identification and quantification of Furanocoumarins in stem bark and wood of eight Algerian varieties of Ficus carica by RP-HPLC-DAD and RP-HPLC-DAD-MS. Nat Prod Commun 8:485–486

    CAS  PubMed  Google Scholar 

  • Runkel M, Moeller A, Tegtmeier M, Willigmann I, Legrum W (1997) Detection of scopolin in the grapefruit (Citrus paradisi MACF.). Fresen J Anal Chem 359:516–520

    Article  CAS  Google Scholar 

  • Rzodkiewicz P, Gasinska E, Gajewski M, Bujalska-Zadrozny M, Szukiewicz D, Maslinski S (2016) Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis. Reumatologia 54:161–164

    Article  PubMed  PubMed Central  Google Scholar 

  • Sarker S, Nahar L (2007) Chemistry for pharmacy students: general, organic and natural product chemistry, eBook ISBN 9781118687536. Wiley, Hoboken

    Book  Google Scholar 

  • Sarker SD, Nahar L (2017) Progress in the chemistry of organic natural products. In: Kinghorn AD, Falk H, Kobayashi J, Gibbons S (eds) Progress in the chemistry of naturally occurring coumarins, vol 106. Springer, Cham, pp 241–304

    Google Scholar 

  • Sarker SD, Nahar L (2018) Computational Phytochemistry. Elsevier, Amsterdam

    Book  Google Scholar 

  • Sekiguchi H, Takabyashi F, Irie K, Murakami A (2012) Auraptene attenuates gastritis via reduction of helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice. J Med Food 15:658–663

    Article  CAS  PubMed  Google Scholar 

  • Selvasundaram R, Manoharan S, Buddhan R, Neelakandan M, Naidu RM (2018) Chemopreventive potential of esculetin in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. Mol Cell Biochem 448:145–153

    Article  CAS  PubMed  Google Scholar 

  • Shalaby NMM, Abd-Alla HI, Ahmed HH, Basoudan N (2011) Protective effect of Citrus sinensis and Citrus aurantifolia against osteoporosis and their phytochemical constituents. J Med Plant Res 5:579–588

    CAS  Google Scholar 

  • Sharma SH, Thulasingam S, Chellappan DR, Chinnaswamy P, Nagarajan S (2017) Morin and esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2-dimethylhydrazine. Eur J Pharmacol 796:20–31

    Article  CAS  PubMed  Google Scholar 

  • Shirsath N, Wagner K, Tanermann S, Schlederer M, Ringel C, Kenner L, Brune B, Wolf P (2018) 8-Methoxypsoralen plus ultraviolet a reduces the psoriatic response to imiquimod in a murine model. Acta Derm Venereol 98:576–584

    Article  CAS  PubMed  Google Scholar 

  • Shokoohinia Y, Bazargan S, Miraghaee S, Javadirad E, Farahani F, Hosseinzadeh L (2017) Safety assessment of osthole isolated from Prangos ferulacea: acute and subchronic toxicities and modulation of cytochrome P450. Jundishapur J Nat Pharm Prod 12:Article number: e63764. https://doi.org/10.5812/jjnpp.63764

    Article  CAS  Google Scholar 

  • Sim MO, Lee HI, Ham JR, Seo KI, Kim MJ, Lee MK (2015) Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats. Nutr Res Pract 9:364–369

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singh G, Bhatti R, Mannan R, Singh D, Kesavan A, Singh P (2018) Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice. Inflammopharmacology. https://doi.org/10.1007/s10787-018-0486-9

    Article  CAS  PubMed  Google Scholar 

  • Skalicka-Wozniak K, Zagaja M, Glowniak K, Luszczki JJ (2014) Purification and anticonvulsant activity of xanthotoxin (8-methoxypsoralen). Cent Eur J Biol 9:431–436

    CAS  Google Scholar 

  • Skalicka-Wozniak K, Budzynska B, Biala G, Boguszewska-Czubara A (2018) Scopolamine-induced memory impairment is alleviated by xanthotoxin: role of acetylcholinesterase and oxidative stress processes. ACS Chem Neurosci 9:1184–1194

    Article  CAS  PubMed  Google Scholar 

  • Song Y, Wang XC, Qin SK, Zhou SH, Li JL, Gao Y (2018) Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep 17:7395–7402

    CAS  PubMed  Google Scholar 

  • Stavri M, Gibbons S (2005) The antimycobacterial constituents of Dill (Anethum graveolens). Phytother Res 19:938–941

    Article  CAS  PubMed  Google Scholar 

  • Su Q, Tao WW, Wang HQ, Chen YY, Huang H, Chen G (2016) Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats. IUBMB Life 68:403–409

    Article  CAS  PubMed  Google Scholar 

  • Subramaniam SR, Ellis EM (2013) Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson’s disease. J Neurosci Res 91:453–461

    Article  CAS  PubMed  Google Scholar 

  • Subramaniam SR, Ellis EM (2016) Umbelliferone and esculetin protect against N-nitrosodiethylamine- induced hepatotoxicity in rats. Cell Biol Int 40:761–769

    Article  CAS  PubMed  Google Scholar 

  • Sun JJ, Chi GF, Soromou LW, Chen N, Guan MF, Wu QC, Wang DC, Li HY (2012) Preventative effect of imperatorin on acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol 14:369–374

    Article  CAS  PubMed  Google Scholar 

  • Sun W, Cai Y, Zhang XX, Chen H, Lin YD, Li H (2017) Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin 38:1120–1128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun XY, Sun LL, Qi H, Gao Q, Wang GX, Wei NN, Wang K (2018) Antipruritic effect of natural coumarin osthole through selective inhibition of thermosensitive TRPV3 channel in the skin. Mol Pharmacol 94:1164–1173

    Article  CAS  PubMed  Google Scholar 

  • Tabana YM, Hassan LEA, Ahamed MBK, Dahham SS, Iqbal MA, Saeed MAA, Khan MSS, Sandai D, Majid ASA, Oon CE, Majid AMSA (2016) Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. Microvasc Res 107:17–33

    Article  CAS  PubMed  Google Scholar 

  • Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T, Murakami S, Kawada T (2011) Auraptene regulates gene expression involved in lipid metabolism through PPARa activation in diabetic obese mice. Mol Nutr Food Res 55:1791–1797

    Article  CAS  PubMed  Google Scholar 

  • Tao WW, Zuo T, Ma CH, Long HY (2016) Suppressing receptor-interacting protein 140: a new sight for esculetin to treat myocardial ischemia/reperfusion injury. RSC Adv 6:112117–112128

    Article  CAS  Google Scholar 

  • Tao ZY, Gao P, Yan YH, Li HY, Song J, Yang JX (2017) Osthole enhances the therapeutic efficiency of stem cell transplantation in neuroendoscopy caused traumatic brain injury. Biol Pharm Bull 40:1043–1054

    Article  CAS  PubMed  Google Scholar 

  • Tatum JH, Berry RE (1977) 6,7-Dimethoxycoumarin in peels of Citrus. Phytochemistry 16:1091–1092

    Article  CAS  Google Scholar 

  • Ulubelen A, Ertugrul L, Birman H, Yigit R, Erseven G, Olgac V (1994) Antifertility effects of some coumarins isolated from Ruta chalepensis and R. chalepensis var latifolia in rodents. Phytother Res 8:233–236

    Article  CAS  Google Scholar 

  • Vakili T, Iranshai M, Arab H, Riahi B, Roshan NM, Karimi G (2017) Safety evaluation of auraptene in rats in acute and subacute toxicity studies. Regul Toxicol Pharmacol 91:159–164

    Article  CAS  PubMed  Google Scholar 

  • Vieyra-Garcia P, Crouch JD, O’Malley JT, Seger EW, Yang CH, Teague JE, Vromans AM, Gehad A, Win TS, Thet S, Yu Z, Lowry EL, Na J-I, Rook AH, Wolf P, Clark RA (2019) Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma. JCI Insight 4. https://doi.org/10.1172/jci.insight.124233

  • Volnukhin VA, Samsonov VA, Kravtsova IV, Tsaregorodtseva EE, Lukashina TV, Val EV (2006) Efficiency of PUVA bath therapy in psoriatic patients. Vestn Dermatol Venerol 5:56–61

    Google Scholar 

  • Wagstaff DJ (1991) Dietary exposure to furanocoumarins. Regul Toxicol Pharmacol 14:261–272

    Article  CAS  PubMed  Google Scholar 

  • Wan CF, Wei YY, Ma JG, Geng XY (2018) Protective effects of scoparone against ischemia-reperfusion-induced myocardial injury. Mol Med Rep 18:1752–1760

    CAS  PubMed  Google Scholar 

  • Wang YH, Avula B, Nanayakkara NP, Zhao J, Khan IA (2013) Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States. J Agric Food Chem 8(61):4470–4476

    Article  CAS  Google Scholar 

  • Wang YH, Liu YH, He GR, Lv Y, Du GH (2015a) Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats. BMC Complement Altern Med 15:Article no. 402. https://doi.org/10.1186/s12906-015-0817-y

  • Wang XX, Li RP, Wang X, Fu Q, Ma SP (2015b) Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome. Neurosci Lett 600:182–187

    Article  CAS  PubMed  Google Scholar 

  • Wang F, Li J, Li G, Bai M, Huang Q (2017a) Angelicin inhibits liver cancer growth in vitro and in vivo. Mol Med Rep 16:5441–5449

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Li S-F, Wang T, Sun C-H, Wang L, Huang M-J, Chen J, Zheng S-W, Wang N, Zhang Y-J, Chen T-Y (2017b) Isopsoralen-mediated suppression of bone marrow adiposity and attenuation of the adipogenic commitment of bone marrow-derived mesenchymal stem cells. Int J Mol Med 39:527–538

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang JJ, Fu YH, Wei ZK, He XX, Shi MY, Kou JH, Zhou ES, Liu WJ, Yang ZT, Guo CM (2017c) Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model. Respir Physiol Neurobiol 239:64–69

    Article  CAS  PubMed  Google Scholar 

  • Wang P, Ying J, Luo C, Jin X, Zhang SX, Xu TT, Zhang L, Mi M, Chen D, Tong PJ, Jin HT (2017d) Osthole promotes bone fracture healing through activation of BMP signaling in chondrocytes. Int J Biol Sci 13:996–1007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Wang G, Gong L, Sun GW, Shi B, Bao HH, Duan Y (2018a) Isopsoralen regulates PPAR-/WNT to inhibit oxidative stress in osteoporosis. Mol Med Rep 17:1125–1131

    CAS  PubMed  Google Scholar 

  • Wang Y, Zhang H, Jiang J-M, Zheng D, Chen Y-Y, Wan S-J, Tan H-S, Tang L-M, Xu H-X (2018b) Hepatotoxicity induced by psoralen and isopsoralen from fructus psoraleae: Wistar rats are more vulnerable than ICR mice. Food Chem Toxicol 125:133–140

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Huang SS, Xin X, Ren Y, Weng GB, Wang P (2019a) The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110 gamma catalytic subunit of PI3K gamma. Acta Pharma 69:111–119

    Article  CAS  Google Scholar 

  • Wang D, Wang X, Tong W, Cui Y, Li X, Sun H (2019b) Umbelliferone alleviates lipopolysaccharide-induced inflammatory responses in acute lung injury by down-regulating tlr4/myd88/nf-kappab signaling. Inflammation. https://doi.org/10.1007/s10753-018-00953-4

    Article  CAS  PubMed  Google Scholar 

  • Wang CL, Al-Ani MK, Sha YQ, Chi QJ, Dong NG, Yang L, Xu K (2019c) Psoralen protects chondrocytes, exhibits anti-inflammatory effects on synoviocytes, and attenuates monosodium lodoacetate-induced osteoarthritis. Int J Biol Sci 15:229–238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei DZ, Guo XY, Lin LN, Lin MX, Gong YQ, Ying BY, Huang MY (2016) Effects of angelicin on ovalbumin (OVA)-induced airway inflammation in a mouse model of asthma. Inflammation 39:1876–1882

    Article  CAS  PubMed  Google Scholar 

  • Wijerathne CUB, Seo CS, Song JW, Park HS, Moon O-S, Won YS, Kwon HJ, Son HY (2017) Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. Int Immunopharmacol 49:67–76

    Article  CAS  PubMed  Google Scholar 

  • Witaicenis A, Luchini AC, Hiruma-Lima CA, Felisbino SL, Justulin LA, Garrido-Mesa N, Utrilla P, Di Stasi LC (2014) Mechanism and effect of esculetin in an experimental animal model of inflammatory bowel disease. Eur J Inflamm 11:433–446

    Article  Google Scholar 

  • Wu HJ, Wu HB, Zhao YQ, Chen LJ, Zou HZ (2016) Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion. Oncol Rep 36:324–332

    Article  CAS  PubMed  Google Scholar 

  • Wu CY, Sun ZP, Guo BF, Ye YY, Han XH, Qin YN, Liu S (2017) Osthole inhibits bone metastasis of breast cancer. Oncotarget 8:58480–58493

    PubMed  PubMed Central  Google Scholar 

  • Wu JG, Yang Y, Xun N, Zeng LJ, Li ZY, Yang W, Liang YB, Ma ZF, Tang H (2018a) Osthole attenuates myocardial ischemia/reperfusion injury in rats by inhibiting apoptosis and inflammation. Am J Transl Res 10:1109–1116

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wu XX, Wang XX, Ren XS, Chen DY, Han YY, Zhang J (2018b) Effects of psoralen, a traditional Chinese medicine, on relapse and bone remodeling after orthodontic tooth movement in rats. Int J Clin Exp Med 11:3587–3595

    Google Scholar 

  • Xia Q, Wei LY, Zhang Y, Kong HT, Shi YP, Wang X, Chen XQ, Han LW, Liu KC (2018) Psoralen induces developmental toxicity in zebrafish embryos/larvae through oxidative stress, apoptosis, and energy metabolism disorder. Front Pharmacol 9:Article number 1457. https://doi.org/10.3389/fphar.2018.01457

    Article  CAS  PubMed  Google Scholar 

  • Xian Z-M, Wang C-Y, Piao Y-H, Li J-F, Jiang J-Z, Zhao Y-Z, Li L-C, Piao H, Yan G-H (2018) Effects of imperatorin on airway remodelling in asthmatic mice through TGF-beta1/Smad3 and PI3K/Akt signaling pathways. Chin Pharmacol Bull 34:1719–1724

    Google Scholar 

  • Xiao JJ, Zhao WJ, Zhang XT, Zhao WL, Wang XX, Yin SH, Jiang F, Zhao YX, Chen FN, Li SL (2015) Bergapten promotes bone marrow stromal cell differentiation into osteoblasts in vitro and in vivo. Mol Cell Biochem 409:113–122

    Article  CAS  PubMed  Google Scholar 

  • Xie ZX, Wen T, Zhang ZC, Huang KY, Wu TS, Liu JH, Wang XK (2018) Immunomodulatory effects of bergapten attenuates D-galactose-induced aging model in Balb/c mice. Int J Pharmacol 14:936–944

    Article  Google Scholar 

  • Xu RG, Liu Z, Hou JD, Huang T, Yang M (2018) Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. Cell Mol Biol Lett 23:Article number: 19. https://doi.org/10.1186/s11658-018-0086-0

    Article  CAS  PubMed Central  Google Scholar 

  • Yan YH, Kong L, Xia Y, Liang WB, Wang LT, Song J, Yao YJ, Lin Y, Yang JX (2018) Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury. Brain Behav Immun 67:118–129

    Article  CAS  PubMed  Google Scholar 

  • Yang L (2013) Use of total coumarins of cnidium fruit in preparing medicaments for treating psoriasis. Patent number: US 08518460, Official Gazette of the United States Patent and Trademark Office Patents

    Google Scholar 

  • Yang M, Teng GP, Li GJ, Huang T, Xu RG (2018a) Effectiveness of osthole on uric acid crystal-induced acute gouty arthritis through the inhibition of NLRP3 inflammasome. Int J Pharmacol 14:1169–1178

    Article  Google Scholar 

  • Yang Y, Zheng KD, Mei WJ, Wang YD, Yu CQ, Yu BW, Deng SB, Hu JH (2018b) Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model. Biochem Biophys Res Commun 496:763–769

    Article  CAS  PubMed  Google Scholar 

  • Yao YF, Zhao XQ, Xin JX, Wu YQ, Li HB (2018a) Coumarins improved type 2 diabetes induced by high-fat diet and streptozotocin in mice via antioxidation. Can J Physiol Pharmacol 96:765–771

    Article  CAS  PubMed  Google Scholar 

  • Yao F, Zhang LR, Jiang GR, Liu M, Liang GQ, Yuan Q (2018b) Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor-B and vascular endothelial growth factor. Oncol Lett 16:4471–4479

    PubMed  PubMed Central  Google Scholar 

  • Yao L, Yang YX, He GH, Ou CQ, Wang L, Liu KX (2018c) Global proteomics deciphered novel-function of osthole against pulmonary arterial hypertension. Sci Rep 8:Article number: 5556. https://doi.org/10.1038/s41598-018-23775-8

    Article  CAS  Google Scholar 

  • Yao Y, Wang Y, Kong L, Chen Y, Yang J (2019) Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer’s disease. Life Sci 217:16–24

    Article  CAS  PubMed  Google Scholar 

  • Ye XD, Ouyang H, Zhong LY, Li TE, Rao XY, Feng YL, Yang WL (2016) Rapid and sensitive LC-MS/MS method for the determination of auraptene in rat plasma and its application in a pharmacokinetic and bioavailability study in rats. Genet Mol Res 15:Article number: 15028786. https://doi.org/10.4238/gmr.15028786

    Article  CAS  Google Scholar 

  • Yin JN, Wang HQ, Lu GY (2018) Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant. Biosci Rep 38:Article number: BSR20180444. https://doi.org/10.1042/BSR20180444

    Article  Google Scholar 

  • Yoo A, Narayan VP, Hong EY, Whang WK, Park T (2017) Scopoletin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver. Sci Rep 7:Article number: 2251. https://doi.org/10.1038/s41598-017-02416-6

    Article  CAS  Google Scholar 

  • Yordi EG, Matos MJ, Martinez AP, Tornes AC, Santana L, Molina E, Uriarte E (2017) In silico genotoxicity of coumarins: application of the phenol-explorer food database to functional food science. Food Funct 8:2958–2966

    Article  Google Scholar 

  • Yu XA, Azietaku JT, Li J, An MR, He J, Hao J, Cao J, Chang YX (2016) The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J 10:Article number: 62. https://doi.org/10.1186/s13065-016-0212-x

    Article  CAS  Google Scholar 

  • Yu KV, Shimorova YE, Boyko NN, Pisarev DI, Zhilyakova ET, Novikov OO (2017) HPLC analysis of hydro-ethanolic extracts from Pastinaca sativa L. fruits. Res J Pharm Biol Chem Sci 8:705–712

    Google Scholar 

  • Yuan XM, Bi YN, Yan ZM, Pu WL, Li YH, Zhou K (2016) Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. Biomed Res Int. Article no. 6869452. https://doi.org/10.1155/2016/6869452

    Google Scholar 

  • Zhang TZ, Wang SM (2015) Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-kappa B pathways. Inflammation 38:1529–1536

    Article  CAS  Google Scholar 

  • Zhang Y, Cao YJ, Duan HJ, Wang HY, He LC (2012) Imperatorin prevents cardiac hypertrophy and the transition to heart via NO-dependent mechanisms in mice. Fitoterapia 83:60–66

    Article  CAS  PubMed  Google Scholar 

  • Zhang ZR, Leung WN, Li G, Kong SK, Lu X, Wong YM, Chan CW (2017a) Osthole enhances osteogenesis in osteoblasts by elevating transcription factor osterix via cAMP/CREB signaling in vitro and in vivo. Nutrients 9:Article number: 588. https://doi.org/10.3390/nu9060588

    Article  CAS  Google Scholar 

  • Zhang XX, Li WC, Abdurehman A, Cheng T, Peng P (2017b) Imperatorin possesses notable anti-inflammatory activity in vitro and in vivo through inhibition of the NF-kappa B pathway. Mol Med Rep 16:8619–8616

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang J, Wen Q, Xu X, Chen L, Feng Y-L, Yang S-L, Luo Y, Tan T (2018a) In vivo metabolism of three coumarins from Chimonanthi Radix based on UHPLC-QTOF-MS/MS. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China J Chin Mater Med 43:4330–4338

    Google Scholar 

  • Zhang SP, Huang Q, Cai XX, Jiang S, Xu N, Zhou Q, Cao XY, Hultstrom M, Tian J, Lai EY (2018b) Osthole ameliorates renal fibrosis in mice by suppressing fibroblast activation and epithelial-mesenchymal transition. Front Physiol 9:Article number: 1650. https://doi.org/10.3389/fphys.2018.01650

    Article  PubMed Central  Google Scholar 

  • Zhang J-M, Yi Z-X, Lin S-Q, Wang Y-M, Wei M, Sun LB, Zou X-N (2018c) Effect of osthole on p38 MAPK signaling related pathway of rat model with inflammatory radicular pain induce by nucleus pulposus in the spinal horn. Chin Pharmacol Bull 34:237–242

    CAS  Google Scholar 

  • Zhao XL, Chen LF, Wang Z (2017) Aesculin modulates bone metabolism by suppressing receptor activator of NF-kappa B ligand (RANKL)-induced osteoclastogenesis and transduction signals. Biochem Biophys Res Commun 488:15–21

    Article  CAS  PubMed  Google Scholar 

  • Zhao Y-X, Wang M, Dong W-T, Li Y (2018a) Pharmacokinetics, bioavailability and metabolism of scopoletin in dog by ultra-high-performance liquid chromatography combined with linear ion trap-orbitrap tandem mass spectrometry. Biomed Chromatogr 33:e4436. https://doi.org/10.1002/bmc.4436

    Article  CAS  PubMed  Google Scholar 

  • Zhao D, Wang Q, Zhao Y, Zhang H, Sha N, Tang D, Liu S, Lu S, Shi Q, Zhang Y, Dong Y, Wang Y, Shu B (2018b) The naturally derived small compound osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice. Menopause 25:1459–1469

    Article  PubMed  Google Scholar 

  • Zhao X, Wang F, Zhou RJ, Zhu ZY, Xie ML (2018c) PPAR alpha/gamma antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. Inflammopharmacology 26:425–433

    Article  CAS  PubMed  Google Scholar 

  • Zheng L, Yang L, Wang Z, Chen C, Su Y (2015) Protective effect of esculin in adjuvant-induced arthritic (AIA) rats via attenuating pro-inflammatory cytokines and oxidative stress. Cell Mol Biol 61:1–5

    CAS  PubMed  Google Scholar 

  • Zheng SY, Ma Y, Guo Y, Wang LN, Pan YL (2018) Osthole promote differentiation and inhibit proliferation of osteoblast by activating wnt signaling and endoplasmic reticulum stress. Pharmacogn Mag 14:641–646

    Article  CAS  Google Scholar 

  • Zhou Y, Wang J, Yang WD, Qi XW, Lan L, Luo L, Yin ZM (2017) Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge. Int J Pharmacol 48:159–168

    CAS  Google Scholar 

  • Zhou W-B, Zhang X-X, Cai Y, Sun W, Li H (2018) Osthole prevents tamoxifen-induced liver injury in mice. Acta Pharmacol Sin. https://doi.org/10.1038/s41401-018-0171-y

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Zhu LP, Nang C, Luo F, Pan H, Zhang K, Liu J, Zhou R, Gao J, Chang XY, He H, Qiu Y, Wang JL, Long HY, Liu Y, Yan TH (2016) Esculetin attenuates lipopolysaccharide (LPS)-induced neuroinflammatory processes and depressive-like behavior in mice. Physiol Behav 163:184–192

    Article  CAS  PubMed  Google Scholar 

  • Zhu XY, Gu JP, Qian HX (2018a) Esculetin attenuates the growth of lung cancer by downregulating Wnt targeted genes and suppressing NF-kappa B. Arch Bronchoneumol 54:128–133

    Google Scholar 

  • Zhu XB, Li ZZ, Li TT, Long F, Lv YS, Liu L, Liu XF, Zhan QM (2018b) Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. Biomed Pharmacother 102:502–209

    Article  CAS  PubMed  Google Scholar 

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  1. Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK

    Satyajit D. Sarker & Lutfun Nahar

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  1. Institute of Chinese Medical Sciences, University of Macau Institute of Chinese Medical Sciences, Macau, Macao

    Jianbo Xiao

  2. School of Pharmacy & Biomolecular Sci., Liverpool John Moores University School of Pharmacy & Biomolecular Sci., Liverpool, UK

    Satyajit D. Sarker

  3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University Faculty of Pharmaceutical Sciences, Tokushima, Japan

    Yoshinori Asakawa

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Sarker, S.D., Nahar, L. (2020). Dietary Coumarins. In: Xiao, J., Sarker, S., Asakawa, Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. https://doi.org/10.1007/978-981-13-1745-3_37-1

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