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Plant Kingdom as Source of Vitamins

  • Living reference work entry
  • First Online:
Handbook of Dietary Phytochemicals

Abstract

A vitamin is an organic substance necessary, in small quantities, for the correct functioning of the metabolism of a living organism. It is an essential nutrient because this substance cannot be synthesized in sufficient quantity by this organism and thus must be provided through the food intake. Each organism has specific needs: a molecule can be a vitamin for one species and not be it for another. It is the case for example of Vitamin C. Some vitamins are water-soluble compounds, including all vitamin Bs (B1, B2, B3, B5, B6, B7, B9, B12) and vitamin C. Others are fat-soluble compounds and encompass vitamins A, D, E, and K. In this chapter, we have chosen to provide an overview of recent literature data only about vitamins provided exclusively or significantly by plant food, in particular vitamins A (as provitaminic carotenoids), B1, B9, C, E, and K1. Vitamins provided by animal food, such as vitamin D or vitamin B12, will be not discussed in this chapter.

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References

  • Abner EL, Schmitt FA, Mendiondo MS et al (2011) Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci 4:158–170

    CAS  PubMed  PubMed Central  Google Scholar 

  • Agarwal A, Shaharyar A, Kumar A et al (2015) Scurvy in pediatric age group – a disease often forgotten? J Clin Orthop Trauma 6:101–107

    PubMed  PubMed Central  Google Scholar 

  • Age-Related Eye Disease Study Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119:1417–1436

    PubMed Central  Google Scholar 

  • Agius F, González-Lamothe R, Caballero JL et al (2003) Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase. Nat Biotechnol 21:177–181

    CAS  PubMed  Google Scholar 

  • Ajjawi I, Rodriguez Milla MA et al (2007) Determination of the genetic, molecular and biochemical basis of the Arabidopsis thaliana thiamin auxotroph th1. Arch Biochem Biophys 459:107–114

    CAS  PubMed  Google Scholar 

  • Akbari S, Rasouli-Ghahroudi AA (2018) Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies. BioMed Res Int 2018:1–8

    Google Scholar 

  • Alagoz Y, Nayak P, Dhami N et al (2018) cis-carotene biosynthesis, evolution and regulation in plants: the emergence of novel signaling metabolites. Arch Biochem Biophys 654:172–184

    CAS  PubMed  Google Scholar 

  • Alapatt P, Guo F, Komanetsky SM et al (2013) Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem 288:1250–1265

    CAS  PubMed  Google Scholar 

  • Al-Khudairy L, Flowers N, Wheelhouse R et al (2017) Vitamin C supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 3:CD011114

    PubMed  Google Scholar 

  • Allenby G, Bocquel MT, Saunders M et al (1993) Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 90:30–34

    CAS  PubMed  PubMed Central  Google Scholar 

  • Amanullah I, Khan YH, Anwar I et al (2019) Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials. Postgrad Med J 95:601–611

    CAS  PubMed  Google Scholar 

  • Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S et al (2013) Two carotenoid oxygenases contribute to mammalian provitamin a metabolism. J Biol Chem 288:34081–34096

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ang A, Pullar JM, Currie MJ, Vissers MCM (2018) Vitamin C and immune cell function in inflammation and cancer. Biochem Soc Trans 46:1147–1159

    CAS  PubMed  PubMed Central  Google Scholar 

  • ANSES (2017) Ciqual, the French food composition database. https://ciqual.anses.fr/. Updated 2017, consulted 1 June 2020

  • Antille C, Tran C, Sorg O et al (2004) Topical beta-carotene is converted to retinyl esters in human skin ex vivo and mouse skin in vivo. Exp Dermatol 13:558–561

    CAS  PubMed  Google Scholar 

  • Anushiravani A, Haddadi N, Pourfarmanbar M et al (2019) Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial. Eur J Gastroenterol Hepatol 31:613–617

    CAS  PubMed  Google Scholar 

  • Ariaey-Nejad MR, Balaghi M, Baker EM et al (1970) Thiamin metabolism in man. Am J Clin Nutr 23:764–778

    CAS  PubMed  Google Scholar 

  • Ashor AW, Lara J, Mathers JC et al (2014) Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. Atherosclerosis 235:9–20

    CAS  PubMed  Google Scholar 

  • Ashor AW, Brown R, Keenan PD et al (2019) Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses. Nutr Res 61:1–12

    CAS  PubMed  Google Scholar 

  • Asson-Batres MA, Norwood CW (2020) Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny. Meth Enzymol 637:341–365

    Google Scholar 

  • Aufreiter S, Gregory JF III, Pfeiffer CM et al (2009) Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid. Am J Clin Nutr 90:116–123

    CAS  PubMed  PubMed Central  Google Scholar 

  • Aune D (2019) Plant foods, antioxidant biomarkers, and the risk of cardiovascular disease, cancer, and mortality: a review of the evidence. Adv Nutr 10:S404–S421

    PubMed  PubMed Central  Google Scholar 

  • Aune D, Keum N, Giovannucci E et al (2018) Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies. Am J Clin Nutr 108:1069–1091

    PubMed  PubMed Central  Google Scholar 

  • Aziz F, Patil P (2015) Role of prophylactic vitamin K in preventing antibiotic induced hypoprothrombinemia. Indian J Pediatr 82:363–367

    PubMed  Google Scholar 

  • Azzi A (2018) Many tocopherols, one vitamin E. Mol Aspects Med 61:92–103

    CAS  PubMed  Google Scholar 

  • Azzi A (2019) Tocopherols, tocotrienols and tocomonoenols: many similar molecules but only one vitamin E. Redox Biol 26:101259

    PubMed  PubMed Central  Google Scholar 

  • Baba Y, Morisawa H, Saito K et al (2016) Intraperitoneal hemorrhage in a pregnant woman with hyperemesis gravidarum: vitamin K deficiency as a possible cause. Case Rep Obstet Gynecol 2016:5384943. https://doi.org/10.1155/2016/5384943

    Article  PubMed  PubMed Central  Google Scholar 

  • Baggott JE, Tamura T (2001) Metabolism of 10-formyldihydrofolate in humans. Biomed Pharmacother 55:454–457

    CAS  PubMed  Google Scholar 

  • Baggott JE, Tamura T (2015) Folate-dependent purine nucleotide biosynthesis in humans. Adv Nutr 6:564–571

    CAS  PubMed  PubMed Central  Google Scholar 

  • Barros AIRNA, Nunes FM, Gonçalves B et al (2011) Effect of cooking on total vitamin C contents and antioxidant activity of sweet chestnuts (Castanea sativa Mill.). Food Chem 128:165–172

    CAS  PubMed  Google Scholar 

  • Basset G, Quinlivan EP, Ziemak MJ et al (2002) Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci USA 99:12489–12494

    CAS  PubMed  PubMed Central  Google Scholar 

  • Basset G, Latimer S, Fatihi A et al (2017) Phylloquinone (vitamin K1): occurrence, biosynthesis and functions. Mini Rev Med Chem 17:1028–1038

    CAS  PubMed  Google Scholar 

  • Batten ML, Imanishi Y, Maeda T et al (2004) Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem 279:10422–10432

    CAS  PubMed  Google Scholar 

  • Bay AR (2008) Beriberi, military medicine, and medical authority in prewar Japan. Japan Rev 20:111–156

    Google Scholar 

  • Bayes J, Agrawal N, Schloss J (2019) The bioavailability of various oral forms of folate supplementation in healthy populations and animal models: a systematic review. J Alternat Complement Med 25:169–180

    Google Scholar 

  • Begley TP (1996) The biosynthesis and degradation of thiamin (vitamin B1). Nat Prod Rep 13:177–185

    CAS  PubMed  Google Scholar 

  • Bendich A, Cohen M (1990) Ascorbic acid safety: analysis of factors affecting iron absorption. Toxicol Lett 51:189–201

    CAS  PubMed  Google Scholar 

  • Berkner KL, Harbeck M, Lingenfelter S et al (1992) Purification and identification of bovine liver gamma-carboxylase. Proc Nat Acad Sci USA 89:6242–6246

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bernstein LH, Gutstein S, Weiner SV (1970) Gamma glutamyl carboxypeptidase (conjugase), the folic acid-releasing enzyme of intestinal mucosa. Am J Clin Nutr 23:919–925

    CAS  PubMed  Google Scholar 

  • Bettendorff L, Lakaye B, Kohn G et al (2014) Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis 29:1069–1082

    CAS  PubMed  Google Scholar 

  • Bhandari SD, Gregory JF III (1990) Inhibition by selected food components of human and porcine intestinal pteroylpolyglutamate hydrolase activity. Am J Clin Nutr 51:87–94

    CAS  PubMed  Google Scholar 

  • Bhatt T, Patel T (2020) Carotenoids: potent to prevent diseases review. Nat Prod Bioprospect 10:109–117

    CAS  PubMed  PubMed Central  Google Scholar 

  • Birringer M, Lorkowski S (2019) Vitamin E: Regulatory role of metabolites. IUBMB Life 71:479–486

    Google Scholar 

  • Blair JA, Pearson AJ, Robb AJ (1975) Autoxidation of 5- methyl -5,6,7,8-tetra hydrofolic acid. J Chem Soc Perkin Trans 2(1):18–21

    Google Scholar 

  • Blaner WS, O’Byrne SM, Wongsiriroj N et al (2009) Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. BBA Mol Cell Biol Lipids 1791:467–473

    CAS  Google Scholar 

  • Bleys J, Miller ER, Pastor-Barriuso R et al (2006) Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am J Clin Nutr 84:880–887

    CAS  PubMed  Google Scholar 

  • Blomhoff R, Blomhoff HK (2006) Overview of retinoid metabolism and function. J Neurobiol 66:606–630

    CAS  PubMed  Google Scholar 

  • Booth SL, Suttie JW (1998) Dietary intake and adequacy of vitamin K. J Nutr 128:785–788

    CAS  PubMed  Google Scholar 

  • Borel P, Lietz G, Goncalves A et al (2013a) CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans. J Nutr 143:448–456

    CAS  PubMed  Google Scholar 

  • Borel P, Preveraud D, Desmarchelier C (2013b) Bioavailability of vitamin E in humans: an update. Nutr Rev 71:319–331

    PubMed  Google Scholar 

  • Borel P, Desmarchelier C, Nowicki M et al (2015) A combination of single-nucleotide polymorphisms is associated with interindividual variability in dietary β-carotene bioavailability in healthy men. J Nutr 145:1740–1747

    CAS  PubMed  Google Scholar 

  • Brand JC, Cherikoff V (1985) The nutritional composition of Australian Aboriginal food plants of the desert regions. In: Wickens GE, Goodin JR, Field DV (eds) Plants for arid lands. Springer, Dordrecht, pp 53–68

    Google Scholar 

  • Breithaupt DE, Bamedi A, Wirt U (2002) Carotenol fatty acid esters: easy substrates for digestive enzymes? Comp Biochem Physiol B 132:721–728

    PubMed  Google Scholar 

  • Brigelius-Flohé R, Traber MG (1999) Vitamin E: function and metabolism. FASEB j 13:1145–1155

    PubMed  Google Scholar 

  • Bril F, Biernacki DM, Kalavalapalli S et al (2019) Role of vitamin E for nonalcoholic steatohepatitis in patients with type 2 diabetes: a randomized controlled trial. Diabetes Care 42:1481–1488

    CAS  PubMed  Google Scholar 

  • Brin M (1962) Erythrocyte transketolase in early thiamine deficiency. Ann NY Acad Sci 98:528–541

    CAS  PubMed  Google Scholar 

  • Brown G (2014) Defects of thiamine transport and metabolism. J Inherit Metab Dis 37:577–585

    CAS  PubMed  Google Scholar 

  • Buettner GR (1993) The pecking order of free radicals and antioxidants: lipid peroxidation, α-tocopherol, and ascorbate. Arch Biochem Biophys 300:535–543

    CAS  PubMed  Google Scholar 

  • Bügel V (2008) Vitamin K and bone health in adult humans. Vit Horm 78:393–416

    Google Scholar 

  • Bureau S, Mouhoubi S, Touloumet L et al (2015) Are folates, carotenoids and vitamin C affected by cooking? Four domestic procedures are compared on a large diversity of frozen vegetables. LWT Food Sci Technol 64:735–741

    CAS  Google Scholar 

  • Burri BJ, La Frano LR, Zhu C (2016) Absorption, metabolism, and functions of β-cryptoxanthin. Nutr Rev 74:69-82

    Google Scholar 

  • Butterworth RF (2009) Thiamine deficiency-related brain dysfunction in chronic liver failure. Metab Brain Dis 24:189–196

    CAS  PubMed  Google Scholar 

  • Butterworth RF, Giguère JF, Besnard AM (1986) Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-ketoglutarate dehydrogenase. Neurochem Res 11:567–577

    CAS  PubMed  Google Scholar 

  • Cachia O, Benna JE, Pedruzzi E et al (1998) alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation. J Biol Chem 273:32801–32805

    CAS  PubMed  Google Scholar 

  • Caffrey A, McNulty H, Irwin RE et al (2018) Maternal folate nutrition and offspring health: evidence and current controversies. Proc Nutr Soc 26:1–13

    Google Scholar 

  • Camarena V, Wang G (2016) The epigenetic role of vitamin C in health and disease. Cell Mol Life Sci 73:1645–1658

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cancela ML, Laizé V, Conceição N (2014) Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Arch Biochem Biophys 561:56–63

    CAS  PubMed  Google Scholar 

  • Cankurtaran M, Kav T, Yavuz B et al (2006) Serum vitamin-E levels and its relation to clinical features in nonalcoholic fatty liver disease with elevated ALT levels. Acta Gastroenterol Belg 69:5–11

    CAS  PubMed  Google Scholar 

  • Cardoso L d M, Montini TA, Pinheiro SS et al (2014) Effects of processing with dry heat and wet heat on the antioxidant profile of sorghum. Food Chem 152:210–217

    CAS  Google Scholar 

  • Caritá AC, Fonseca-Santos B, Shultz JD et al (2020) Vitamin C: one compound, several uses. Advances for delivery, efficiency and stability. Nanomedicine 24:102117

    PubMed  Google Scholar 

  • Carlier C, Coste J, Etchepare M et al (1993) A randomised controlled trial to test equivalence between retinyl palmitate and beta carotene for vitamin A deficiency. Brit Med J 307:1106–1110

    CAS  PubMed  PubMed Central  Google Scholar 

  • Carmel R (2019) Megaloblastic anemias: disorders of impaired DNA synthesis. In: Greer JP, Rodgers GM, Glader B, Arber DA, Means RT Jr, List AF, Appelbaum FR, Dispenzieri A, Fehniger TA (eds) Wintrobe’s hematology, 14th edn. Wolters Kluwer, Philadelphia.

    Google Scholar 

  • Carpenter KJ (2003a) A short history of nutritional science: part 2 (1885–1912). J Nutr 133:975–984

    CAS  PubMed  Google Scholar 

  • Carpenter KJ (2003b) A short history of nutritional science: part 3 (1912–1944). J Nutr 133:3023–3032

    CAS  PubMed  Google Scholar 

  • Carpenter KJ (2012) The discovery of vitamin C. Ann Nutr Metab 61:259–264

    CAS  PubMed  Google Scholar 

  • Carr A, Vissers M (2013) Synthetic or food-derived vitamin C – are they equally bioavailable? Nutrients 5:4284–4304

    CAS  PubMed  PubMed Central  Google Scholar 

  • Casteels M, Sniekers M, Fraccascia P et al (2007) The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids. Biochem Soc Trans 35:876–880

    CAS  PubMed  Google Scholar 

  • Castenmiller JJM, West CE (1998) Bioavailability and bioconversion of carotenoids. Annu Rev Nutr 18:19–38

    CAS  PubMed  Google Scholar 

  • Caudill MA, Cruz AC, Gregory JF III et al (1997) Folate status response to controlled folate intake in pregnant women. J Nutr 127:2363–2370

    CAS  PubMed  Google Scholar 

  • Centeno Tablante E, Pachón H et al (2019) Fortification of wheat and maize flour with folic acid for population health outcomes. Cochrane Database Syst Rev 7:CD012150

    PubMed  Google Scholar 

  • Chandler LA, Schwartz SJ (1987) HPLC Separation of cis-trans carotene isomers in fresh and processed fruits and vegetables. J Food Sci 52:669–672

    CAS  Google Scholar 

  • Chandler CJ, Wang TTY, Halsted CH (1986) Pteroylpolyglutamate hydrolase from human jejunal brush borders – purification and characterization. J Biol Chem 261:928–933

    CAS  PubMed  Google Scholar 

  • Chandrakumar A, Bhardwaj A, ‘t Jong GW (2018) Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol 30:153–162

    Google Scholar 

  • Chatterjee A, Abeydeera ND, Bale S et al (2011) Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature 478:542–548

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chauvet M (2018) Encyclopédie des plantes alimentaires. Belin/Humensis, Paris

    Google Scholar 

  • Chen Y, Jie W, Yan W et al (2012) Lysine-specific histone demethylase 1 (LSD1): a potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr 22:53–59

    CAS  PubMed  Google Scholar 

  • Chen HG, Sheng LT, Zhang YB et al (2019a) Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis. Eur J Nutr 58:2191–2205

    CAS  PubMed  Google Scholar 

  • Chen W, Zhao S, Wu L et al (2019b) Retinoids as an immunity-modulator in dermatology disorders. Arch Immun Ther Exp 67:355–365

    CAS  Google Scholar 

  • Chichili GR, Nohr D, Schäffer M et al (2005) β-Carotene conversion into vitamin A in Human Retinal Pigment Epithelial cells. Biochem Mol Biol 46:3562–3569

    Google Scholar 

  • Chuah AM, Lee Y-C, Yamaguchi T et al (2008) Effect of cooking on the antioxidant properties of coloured peppers. Food Chem 111:20–28

    CAS  Google Scholar 

  • Ciszak EM, Korotchkina G, Dominiak PM et al (2003) Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. J Biol Chem 278:21240–21246

    CAS  PubMed  Google Scholar 

  • Combs GF Jr, McClung JP (2017) The vitamins – fundamental aspects in nutrition and health. Elsevier/Academic, Amsterdam/Boston

    Google Scholar 

  • Coquille S, Roux C, Mehta A et al (2013) High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. J Struct Biol 184:438–444

    Google Scholar 

  • Corongiu FP, Poli G, Dianzani MU et al (1986) Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo. Chem Biol Interact 59:147–155

    CAS  PubMed  Google Scholar 

  • Crichton GE, Bryan J, Murphy KJ (2013) Dietary antioxidants, cognitive function and dementia – a systematic review. Plant Foods Hum Nutr 68:279–292

    CAS  PubMed  Google Scholar 

  • Curtis AJ, Bullen M, Piccenna L et al (2014) Vitamin E supplementation and mortality in healthy people: a meta-analysis of randomised controlled trials. Cardiovasc Drugs Ther 28:563–573

    CAS  PubMed  Google Scholar 

  • Czeizel AE, Dudás I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. New Engl J Med 327:1832–1835

    CAS  PubMed  Google Scholar 

  • Daba KT, Kifle D, Ababora JK (2019) Bilateral keratomalacia secondary to diet induced vitamin A deficiency in an Ethiopian young woman: a case report. Ethiop J Health Sci 29:295–297

    PubMed  PubMed Central  Google Scholar 

  • Dairi T (2009) An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains. J Antibiot 62:347–352

    CAS  Google Scholar 

  • Dam H (1946) The discovery of vitamin K, its biological functions and therapeutical application. Nobel Lecture. https://www.nobelprize.org/uploads/2018/06/dam-lecture.pdf

  • Damon M, Zhang NZ, Haytowitz DB et al (2005) Phylloquinone (vitamin K1) content of vegetables. J Food Compos Anal 18:751–758

    CAS  Google Scholar 

  • Davis RE, Icke GC, Thom J et al (1984) Intestinal absorption of thiamin in man compared with folate and pyridoxal and its subsequent urinary excretion. J Nutr Sci Vitaminol 30:475–482

    CAS  PubMed  Google Scholar 

  • Davis JL, Paris HL, Beals JW et al (2016) Liposomal-encapsulated ascorbic acid: influence on vitamin C bioavailability and capacity to protect against ischemia-reperfusion injury. Nutr Metab Insights 9:25–30

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dawson MI, Xia Z (2012) The retinoid X receptors and their ligands. Biochim Biophys Acta 1821:21–56

    CAS  PubMed  Google Scholar 

  • De Caterina R, Mundi S, Fusaro M (2020) Vitamin K antagonists and osteoporotic fractures: insights from comparisons with the NOACs. Eur Heart J 41:1109–1111

    PubMed  Google Scholar 

  • De la Fuente M, Hernanz A, Guayerbas N et al (2008) Vitamin E ingestion improves several immune functions in elderly men and women. Free Radic Res 42:272–280

    PubMed  Google Scholar 

  • de Pee S, West CE (1996) Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. Eur J Clin Nutr 50:S38–S53

    PubMed  Google Scholar 

  • Delchier N, Ringling C, Le Grandois J et al (2013) Effects of industrial processing on folate content in green vegetables. Food Chem 139:815–824

    CAS  PubMed  Google Scholar 

  • De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC et al (2015) Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev 12:CD007950

    Google Scholar 

  • Desmarchelier C, Tourniaire F, Prévéraud DP et al (2013) The distribution and relative hydrolysis of tocopheryl acetate in the different matrices coexisting in the lumen of the small intestine during digestion could explain its low bioavailability. Mol Nutr Food Res 57:1237–1245

    CAS  PubMed  Google Scholar 

  • Devnath GP, Kumaran S, Rajiv R et al (2017) Fatal folic acid toxicity in Humans. J Forensic Sci 62:1668–1670

    Article  PubMed  Google Scholar 

  • Dhar I, Svingen GFT, Ueland PM et al (2018) Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris. J Am Heart Assoc 7:e008824

    Article  PubMed  PubMed Central  Google Scholar 

  • Dhar I, Lysne V, Svingen GFT et al (2019) Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease. J Am Clin Nutr 109:1546–1554

    Article  Google Scholar 

  • Diegel CR, Hann S, Ayturk UM et al (2020) An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet 16:e1008361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DiNicolantonio JJ, Niazi AK, Lavie CJ et al (2013) Thiamine supplementation for the treatment of heart failure: a review of the literature. Congest Heart Fail 19:214–222

    Article  CAS  PubMed  Google Scholar 

  • DiNicolantonio JJ, Liu J, O’Keefe JH (2018) Thiamine and cardiovascular disease. Prog Cardiovasc Dis 61:27–32

    Article  PubMed  Google Scholar 

  • Diop Ndiaye N, Dhuique-Mayer C, Cisse M et al (2011) Identification and thermal degradation kinetics of chlorophyll pigments and ascorbic acid from ditax nectar (Detarium senegalense J.F. Gmel). J Agric Food Chem 59:12018–12027

    Article  CAS  PubMed  Google Scholar 

  • Domínguez-Perles R, Mena P, García-Viguera C, Moreno DA (2014) Brassica foods as a dietary source of vitamin C: a review. Crit Rev Food Sci Nutr 54:1076–1091

    Article  PubMed  CAS  Google Scholar 

  • Dörmann P (2007) Functional diversity of tocochromanols in plants. Planta 225:269–276

    Article  PubMed  CAS  Google Scholar 

  • Dowd P, Hershline R, Ham SW et al (1995) Vitamin K and energy transduction: a base strength amplification mechanism. Science 269:1684–1691

    Article  CAS  PubMed  Google Scholar 

  • Du J, Cullen JJ, Buettner GR (2012) Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta Rev Cancer 1826:443–457

    CAS  Google Scholar 

  • Dunn WA, Rettura G, Seifter E, Englard S (1984) Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase. Int J Biol Chem 259:10764–10770

    Google Scholar 

  • During A, Harrison EH (2007) Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res 48:2283–2294

    CAS  PubMed  Google Scholar 

  • During A, Dawson HD, Harrison EH (2005) Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr 135:2305–2312

    CAS  PubMed  Google Scholar 

  • Edge R, Truscott TG (1997) Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutrition 13:992–994

    CAS  PubMed  Google Scholar 

  • EFSA NDA Panel (2009a) Scientific Opinion on the substantiation of health claims related to vitamin A and cell differentiation (ID 14), function of the immune system (ID 14), maintenance of skin and mucous membranes (ID 15, 17), maintenance of vision (ID 16), maintenance of bone (ID 13, 17), maintenance of teeth (ID 13, 17), maintenance of hair (ID 17), maintenance of nails (ID 17), metabolism of iron (ID 206), and protection of DNA, proteins and lipids from oxidative damage (ID 209) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 7:1221

    Google Scholar 

  • EFSA NDA Panel (2009b) Scientific Opinion on substantiation of health claims related to thiamine and energy-yielding metabolism (ID 21, 24, 28), cardiac function (ID 20), function of the nervous system (ID 22, 27), maintenance of bone (ID 25), maintenance of teeth (ID 25), maintenance of hair (ID 25), maintenance of nails (ID 25), maintenance of skin (ID 25) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 7:1222

    Google Scholar 

  • EFSA NDA Panel (2009c) Scientific Opinion on the substantiation of health claims related to folate and blood formation (ID 79), homocysteine metabolism (ID 80), energyyielding metabolism (ID 90), function of the immune system (ID 91), function of blood vessels (ID 94, 175, 192), cell division (ID 193), and maternal tissue growth during pregnancy (ID 2882) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 7:1213

    Google Scholar 

  • EFSA NDA Panel (2009d) Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 7:1226

    Google Scholar 

  • EFSA NDA Panel (2009e) Scientific Opinion on the substantiation of health claims related to vitamin K and maintenance of bone (ID 123, 127, 128, and 2879), blood coagulation (ID 124 and 126), and function of the heart and blood vessels (ID 124, 125 and 2880) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 7:1228

    Google Scholar 

  • EFSA NDA Panel (2010a) Scientific Opinion on the substantiation of health claims related to vitamin A and cell differentiation (ID 14), function of the immune system (ID 14), maintenance of skin and mucous membranes (ID 15, 17), maintenance of vision (ID 16), maintenance of bone (ID 13, 17), maintenance of teeth (ID 13, 17), maintenance of hair (ID 17), maintenance of nails (ID 17), metabolism of iron (ID 206), and protection of DNA, proteins and lipids from oxidative damage (ID 209) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 8:1754

    Google Scholar 

  • EFSA NDA Panel (2010b) Scientific Opinion on the substantiation of health claims related to thiamin and reduction of tiredness and fatigue (ID 23) and contribution to normal psychological functions (ID 205) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 8:1755

    Google Scholar 

  • EFSA NDA Panel (2010c) Scientific Opinion on the substantiation of health claims related to folate and contribution to normal psychological functions (ID 81, 85, 86, 88), maintenance of normal vision (ID 83, 87), reduction of tiredness and fatigue (ID 84), cell division (ID 195, 2881) and contribution to normal amino acid synthesis (ID 195, 2881) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 8:1760

    Google Scholar 

  • EFSA NDA Panel (2010d) Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy-yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 8:1815

    Google Scholar 

  • EFSA NDA Panel (2010e) Scientific Opinion on the substantiation of health claims related to vitamin E and protection of DNA, proteins and lipids from oxidative damage (ID 160, 162, 1947), maintenance of the normal function of the immune system (ID 161, 163), maintenance of normal bone (ID 164), maintenance of normal teeth (ID 164), maintenance of normal hair (ID 164), maintenance of normal skin (ID 164), maintenance of normal nails (ID 164), maintenance of normal cardiac function (ID 166), maintenance of normal vision by protection of the lens of the eye (ID 167), contribution to normal cognitive function (ID 182, 183), regeneration of the reduced form of vitamin C (ID 203), maintenance of normal blood circulation (ID 216) and maintenance of normal a scalp (ID 2873) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 8:1816

    Google Scholar 

  • EFSA NDA Panel (2011) Scientific Opinion on the substantiation of health claims related to beta-carotene and protection of DNA, proteins and lipids from oxidative damage (ID 19, 197, 1262, 1460), protection of the skin from UV-induced (including photo-oxidative) damage (ID 178, 197, 1263, 1461, 1968, 2320) and maintenance of the normal function of the immune system (ID 200, 1462) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 9:2021

    Google Scholar 

  • EFSA NDA Panel (2013a) Scientific Opinion on the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J 11:3328

    Google Scholar 

  • EFSA NDA Panel (2013b) Scientific opinion on dietary reference values for vitamin C. EFSA J 11:3418

    Google Scholar 

  • EFSA NDA Panel (2014) Scientific opinion on dietary reference values for folate. EFSA J 12:3893

    Google Scholar 

  • EFSA NDA Panel (2015a) Scientific opinion on dietary reference values for vitamin A. EFSA J 13:4028

    Article  CAS  Google Scholar 

  • EFSA NDA Panel (2015b) Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J 13:4298

    Google Scholar 

  • EFSA NDA Panel (2015c) Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol. EFSA J 13:4149

    Google Scholar 

  • EFSA NDA Panel (2016) Scientific opinion on dietary reference values for thiamin. EFSA J 14:4653

    Google Scholar 

  • EFSA NDA Panel (2017a) Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J 15:e04685

    Google Scholar 

  • EFSA NDA Panel (2017b) Dietary reference values for vitamin K. EFSA J 15:4780

    Google Scholar 

  • EFSA SCF and NDA Panel (2006) Tolerable upper intake levels for vitamins and minerals. Available online: http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf. Retrieved 29 May 2020

  • Elalfy MS, Ebeid FSE, Ilagouza IA et al (2018) Negative impact of prolonged antibiotics or persistent diarrhea on vitamin K1 levels in 2-24 weeks aged Egyptian infants. Mediterr Hematol J Infect Dis 10(1):e2018010

    Article  Google Scholar 

  • Elmadfa I, Meyer AL (2019) The role of the status of selected micronutrients in shaping the immune function. Endocr Metab Immune Disord Drug Targets 19:1100–1115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Erkkilä AT, Lichtenstein AH, Dolnikowski GG et al (2004) Plasma transport of vitamin K in men using deuterium-labeled collard greens. Metabolism 53:215–221

    Article  PubMed  CAS  Google Scholar 

  • Eshak ES, Arafa AE (2018) Thiamine deficiency and cardiovascular disorders. Nutr Metab Cardiovasc Dis 28:965–972

    Article  CAS  PubMed  Google Scholar 

  • European Pharmacopoeia (2020) Phytomenadione, racemic. Edition 10.1, 01/2020:3011

    Google Scholar 

  • Evans HM, Bishop KS (1922) On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56:650–651

    Article  CAS  PubMed  Google Scholar 

  • Evans JR, Lawrenson JG (2017) Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev 7:CD000253

    PubMed  Google Scholar 

  • Fang X, Wei J, He X et al (2015) Landscape of dietary factors associated with risk of gastric cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer 51:2820–2832

    Article  PubMed  Google Scholar 

  • FAO (2001) Human energy requirements – report of a joint FAO/WHO/UNU expert consultation. FAO food and nutrition technical report series 1. FAO, Rome

    Google Scholar 

  • FAO/WHO (1967) Requirements of vitamin A, thiamine, riboflavine and niacin. Report of a Joint FAO/WHO Expert Group. WHO technical report series 362. World Health Organization, Geneva

    Google Scholar 

  • Farina N, Llewellyn D, Isaac MGEKN et al (2017) Vitamin E for Alzheimer’s dementia and mild cognitive impairment. Cochrane Database Syst Rev 4:CD002854

    PubMed  Google Scholar 

  • Fatihi A, Latimer S, Schmollinger S et al (2015) A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K1 in Synechocystis and Arabidopsis. Plant Cell 27:1730–1741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fenech M, Amaya I, Valpuesta V, Botella MA (2019) Vitamin C content in fruits: biosynthesis and regulation. Front Plant Sci 9. https://doi.org/10.3389/fpls.2018.02006

  • Fernholz E (1938) On the constitution of α-tocopherol. J Am Chem Soc 60:700–705

    Article  CAS  Google Scholar 

  • Fillion L, Henry CJK (1998) Nutrient losses and gains during frying: a review. Int J Food Sci Nutr 49:157–168

    Article  CAS  PubMed  Google Scholar 

  • Fiorini F, Braddick L, Hashim H et al (2018) Lesson of the month 1: massive spontaneous haematomas in an elderly man. Clin Med (Lond) 18:180–182. https://doi.org/10.7861/clinmedicine.18-2-180

    Article  Google Scholar 

  • Fritsche S, Wang X, Jung C (2017) Recent advances in our understanding of tocopherol biosynthesis in plants: an overview of key genes, functions, and breeding of vitamin E improved crops. Antioxidants 6:99

    Article  CAS  PubMed Central  Google Scholar 

  • Fritz H, Flower G, Weeks L et al (2014) Intravenous vitamin C and cancer: a systematic review. Integr Cancer Ther 13:280–300

    Article  CAS  PubMed  Google Scholar 

  • Fujiwara M, Matui K (1953) Anti-thiamine factors of the fern. J Biochem 40:427–434

    Article  CAS  Google Scholar 

  • Fujiwara M, Watanabe H, Matsui K (1954) Allithiamine a newly found derivative of vitamin B1. I. Discovery of allithiamine. J Biochem 41:29–39

    Article  CAS  Google Scholar 

  • Fulan H, Changxing J, Baina WY et al (2011) Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression. Cancer Causes Control 22:1383–1396

    Article  PubMed  Google Scholar 

  • Funk C (1924) Die vitamine. Springer, Berlin/Heidelberg

    Book  Google Scholar 

  • Furie B, Furie BC (1992) Molecular and cellular biology of blood coagulation. N Engl J Med 326:800–806

    Article  CAS  PubMed  Google Scholar 

  • Furie B, Bouchard BA, Furie BC (1999) Vitamin K-dependent biosynthesis of γ-carboxyglutamic acid. Blood 93:1798–1808

    Article  CAS  PubMed  Google Scholar 

  • Galli F, Azzi A, Birringer M et al (2017) Vitamin E: emerging aspects and new directions. Free Radic Biol Med 102:16–36

    Article  CAS  PubMed  Google Scholar 

  • Gangolf M, Czerniecki J, Radermecker M et al (2010) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 5:e13616. https://doi.org/10.1371/journal.pone.0013616

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ganrot PO, Nilehn JE (1968) Plasma prothrombin during treatment with dicumarol. II. Demonstration of an abnormal prothrombin fraction. Scand J Clin Lab Invest 22:23–28

    Article  CAS  PubMed  Google Scholar 

  • García P, Lorenzo P, de Lera AR (2020) Natural ligands of RXR receptors. Meth Enzymol 637:209–234

    Google Scholar 

  • Garcion C, Lohmann A, Lamodière E et al (2008) Characterization and biological function of the isochorismate synthase2 gene of Arabidopsis. Plant Physiol 147:1279–1287

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gardill SL, Suttie JW (1990) Vitamin K epoxide and quinone reductase activities. Evidence for reduction by a common enzyme. Biochem Pharmacol 40:1055–1061

    CAS  PubMed  Google Scholar 

  • Garland DL (1991) Ascorbic acid and the eye. Am J Clin Nutr 54:1198S–1202S

    CAS  PubMed  Google Scholar 

  • Gastaldi G, Casirola D, Patrini C et al (1988) Intestinal transport of thiamin and thiamin monophosphate in rat everted jejunal sacs: a comparative study using some potential inhibitors. Arch Int Physiol Biochim 96:223–230

    CAS  PubMed  Google Scholar 

  • Gibson GE, Hirsch JA, Fonzetti P et al (2016) Vitamin B1 (thiamine) and dementia. Ann NY Acad Sci 1367:21–30

    CAS  PubMed  Google Scholar 

  • Gillberg L, Ørskov AD, Liu M et al (2018) Vitamin C – a new player in regulation of the cancer epigenome. Semin Cancer Biol 51:59–67

    CAS  PubMed  Google Scholar 

  • Ginter E (1989) Ascorbic acid in cholesterol metabolism and in detoxification of xenobiotic substances: problem of optimum vitamin C intake. Nutrition 5:369–374

    CAS  PubMed  Google Scholar 

  • Goncalves A, Margier M, Roi S et al (2014a) Intestinal scavenger receptors are involved in vitamin K 1 absorption. J Biol Chem 289:30743–30752

    CAS  PubMed  PubMed Central  Google Scholar 

  • Goncalves A, Roi S, Nowicki M et al (2014b) Cluster-determinant 36 (CD36) impacts on vitamin E postprandial response. Mol Nutr Food Res 58:2297–2306

    CAS  PubMed  Google Scholar 

  • Gong X, Gutala R, Jaiswal AK (2008) Quinone oxidoreductases and vitamin K metabolism. Vit Horm 78:85–101

    CAS  Google Scholar 

  • Goyer A (2017) Thiamin biofortification of crops. Curr Opin Biotechnol 44:1–7

    Google Scholar 

  • Graat JM, Schouten EG, Kok FJ (2002) Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 288:715–721

    CAS  PubMed  Google Scholar 

  • Graham S, Zielezny M, Marshall J et al (1992) Diet in the epidemiology of postmenopausal breast cancer in the New York State Cohort. Am J Epidemiol 136:1327–1337

    CAS  PubMed  Google Scholar 

  • Graumlich JF, Ludden TM, Conry-Cantilena C et al (1997) Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion. Pharm Res 14:1133–1139

    CAS  PubMed  Google Scholar 

  • Green AS, Tang G, Lango J et al (2011) Domestic cats convert [2H8]-β-carotene to [2H4]-retinol following a single oral dose. J Anim Physiol Anim Nutr 96:681–692

    Google Scholar 

  • Gregory JF (2017) Vitamins. In: Damodaran S, Parkin KL (eds) Fennema’s food chemistry, 5th edn. CRC Press, Boca Raton, pp 543–626

    Google Scholar 

  • Gross J, Cho WK, Lezhneva L et al (2006) A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes. J Biol Chem 281:17189–17196

    CAS  PubMed  Google Scholar 

  • Guéant-Rodriguez RM, Guéant JL et al (2006) Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 83:701–707

    PubMed  Google Scholar 

  • Guggenheim MA, Ringel SP, Silverman A et al (1982) Progressive neuromuscular disease in children with chronic cholestasis and vitamin E deficiency: diagnosis and treatment with alpha tocopherol. J Pediatr 100:51–58

    CAS  PubMed  Google Scholar 

  • Gutzeit D, Baleanu G, Winterhalter P et al (2008) Vitamin C content in sea buckthorn berries (Hippophaë rhamnoides L. ssp. rhamnoides) and related products: a kinetic study on storage stability and the determination of processing effects. J Food Sci 73:C615–C620

    CAS  PubMed  Google Scholar 

  • Haider BA, Sharma R, Bhutta ZA (2017) Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev 2:CD006980

    PubMed  Google Scholar 

  • Halder M, Petsophonsakul P, Akbulut A et al (2019) Vitamin K: double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease. Int J Mol Sci 20:896

    CAS  PubMed Central  Google Scholar 

  • Halioua B, Paul C, Berbis P et al (2019) Efficacy and safety of oral alitretinoin as treatment for chronic hand eczema in France: a real-life open-label study. Eur J Dermatol 29:59–66

    CAS  PubMed  Google Scholar 

  • Hannon-Fletcher MP, Armstrong NC, Scott JM et al (2004) Determining bioavailability of food folates in a controlled intervention study. Am J Clin Nutr 80:911

    CAS  PubMed  Google Scholar 

  • Harada M, Kumemura H, Harada R et al (2005) Scleroderma and repeated spontaneous abortions treated with vitamin E – a case report. Kurume Med J 52:93–95

    PubMed  Google Scholar 

  • Harris HR, Orsini N, Wolk A (2014) Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer 50:1223–1231

    CAS  PubMed  Google Scholar 

  • Harris TA, Gattu S, Propheter DC et al (2019) Resistin-like molecule α provides vitamin-A-dependent antimicrobial protection in the skin. Cell Host Microbe 25:777–788

    CAS  PubMed  PubMed Central  Google Scholar 

  • Harrison EH (2019) Mechanisms of transport and delivery of vitamin A and carotenoids to the retinal pigment epithelium. Mol Nutr Food Res 63:1801046

    Google Scholar 

  • Haskell MJ (2012) The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion – evidence in humans. Am J Clin Nutr 96:1193S–1203S

    CAS  PubMed  Google Scholar 

  • Hasnain G, Roje S, Sa N et al (2016) Bacterial and plant HAD enzymes catalyze a missing phosphatase step in thiamin diphosphate biosynthesis. Biochem J 473:157–166

    CAS  PubMed  Google Scholar 

  • Heath ML, Sidbury R (2006) Cutaneous manifestations of nutritional deficiency. Curr Opin Pediatr 18:417–422

    PubMed  Google Scholar 

  • Hemilä H, Chalker E (2013) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 1:CD000980

    Google Scholar 

  • Hemilä H, Chalker E (2019) Vitamin C can shorten the length of stay in the ICU: a meta-analysis. Nutrients 11:708

    PubMed Central  Google Scholar 

  • Hemila H, Kaprio J (2011) Subgroup analysis of large trials can guide further research: a case study of vitamin E and pneumonia. Clin Epidemiol 3:51–59

    PubMed  PubMed Central  Google Scholar 

  • Hemilä H, Suonsyrjä T (2017) Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis. BMC Cardiovasc Disord 17:49

    PubMed  PubMed Central  Google Scholar 

  • Hemilä H, Virtamo J, Albanes D et al (2004) Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers. Chest 125:557–565

    PubMed  Google Scholar 

  • Hemilä H, Virtamo J, Albanes D, Kaprio J (2006) The effect of vitamin E on common cold incidence is modified by age, smoking and residential neighborhood. J Am Coll Nutr 25:332–339

    PubMed  Google Scholar 

  • Hennebelle T (2020) Troubles de l’hémostase. In: Boutefnouchet S, Girard C, Hennebelle T, Poupon E, Seguin E (eds) Pharmacognosie. Obtention et propriétés des substances actives médicamenteuses d’origine naturelle. Elsevier-Masson, Paris

    Google Scholar 

  • Hosomi A, Arita M, Sato Y et al (1997) Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409:105–108

    CAS  PubMed  Google Scholar 

  • Hoyumpa AM, Strickland R, Sheehan JJ et al (1982) Dual system of intestinal thiamine transport in humans. J Lab Clin Med 99:701–708

    CAS  PubMed  Google Scholar 

  • Hua Y-F, Wang G-Q, Jiang W et al (2016) Vitamin C intake and pancreatic cancer risk: a meta-analysis of published case-control and cohort studies. PLoS ONE 11:e0148816

    PubMed  PubMed Central  Google Scholar 

  • Imdad A, Ahmed Z, Bhutta ZA (2016) Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age. Cochrane Database Syst Rev 9:CD007480

    PubMed  Google Scholar 

  • Imdad A, Mayo-Wilson E, Herzer K et al (2017) Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 3:CD008524

    PubMed  Google Scholar 

  • Ingram BO, Turbyfill JL, Bledsoe PJ et al (2013) Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice. Biochem J 456:47–54

    CAS  PubMed  Google Scholar 

  • Institute of Medicine (U.S.) Panel on Micronutrients (2001) Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy Press, Washington, DC

    Google Scholar 

  • Institute of Medicine (US) (1998) Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Food and Nutrition Board. National Academy Press, Washington, DC, 591 pp

    Google Scholar 

  • Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000) Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academies Press, Washington, DC

    Google Scholar 

  • Isaac MGEKN, Quinn R, Tabet N (2008) Vitamin E for Alzheimer’s disease and mild cognitive impairment. Cochrane Database Syst Rev 4:CD002854

    Google Scholar 

  • Ishigami A (2010) Anti-aging research using SMP30/GNL knockout mice. Yakugaku Zasshi 130:25–28

    CAS  PubMed  Google Scholar 

  • Itagaki H, Hagino T (2019) Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report. BMC Gastroenterol 19(1):58. https://doi.org/10.1186/s12876-019-0978-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Iyen N, Grizotte-Lake M, Duncan K et al (2020) Epithelium intrinsic vitamin A signaling coordinates pathogen clearance in the gut via IL-18. PLoS Pathogens 16:e1008360

    Google Scholar 

  • Jacobs EJ (2002) Vitamin C and vitamin E supplement use and bladder cancer mortality in a large Cohort of US Men and Women. Am J Epidemiol 156:1002–1010

    PubMed  Google Scholar 

  • Jacobs C, Hutton B, Ng T et al (2015) Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist 20:210–223

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jagannath VA, Thaker V, Chang AB et al (2020) Vitamin K supplementation for cystic fibrosis. Cochrane Database Syst Rev 6:CD008482

    PubMed  Google Scholar 

  • Jägerstad M, Jastrebova J (2013) Occurrence, stability, and determination of formyl folates in foods. J Agric Food Chem 61:9758–9768

    PubMed  Google Scholar 

  • Jain A, Mehta R, Al-Ani M et al (2015) Determining the role of thiamine deficiency in systolic heart failure: a meta-analysis and systematic review. J Card Fail 21:1000–1007

    CAS  PubMed  Google Scholar 

  • Jansen BCP, Donath WF (1926) On the isolation of the anti-beri-beri vitamin. Proc R Acad Amsterdam 29:1390–1400

    Google Scholar 

  • Ji H-F, Sun Y, Shen L (2014) Effect of vitamin E supplementation on aminotransferase levels in patients with NAFLD, NASH, and CHC: results from a meta-analysis. Nutrition 30:986–991

    Article  CAS  PubMed  Google Scholar 

  • Jialal I, Devaraj S (1996) The role of oxidized low density lipoprotein in atherogenesis. J Nutr 126:1053S–1057S

    Article  CAS  PubMed  Google Scholar 

  • Jiang Q (2014) Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radic Biol Med 72:76-90

    Google Scholar 

  • Jones KS, Bluck LJC, Wang LY et al (2009) The effect of different meals on the absorption of stable isotope-labelled phylloquinone. Br J Nutr 102:1195–1202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Juhaimi FA, Ghafoor K, Babiker EE et al (2018) Influence of storage and roasting on the quality properties of kernel and oils of raw and roasted peanuts. J Oleo Sci 67:755–762

    Article  PubMed  CAS  Google Scholar 

  • Justi KC, Visentainer JV, Evelázio de Souza N et al (2000) Nutritional composition and vitamin C stability in stored camu-camu (Myrciaria dubia) pulp. Arch Latinoam Nutr 50:405–408

    CAS  PubMed  Google Scholar 

  • Kagan V, Witt E, Goldman R et al (1992) Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin. Free Radic Res Commun 16:51–64

    Article  CAS  PubMed  Google Scholar 

  • Kamatou GPP, Vermaak I, Viljoen AM (2011) An updated review of Adansonia digitata: a commercially important African tree. S Afr J Bot 77:908–919

    Article  Google Scholar 

  • Karrer P, Fritzsche H, Ringier BH, Salomon H (1938) Alpha-Tocopherol. Helv Chim Acta 21:520–525

    Article  CAS  Google Scholar 

  • Kayden HJ, Traber MG (1993) Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res 34:343–358

    CAS  PubMed  Google Scholar 

  • Kaylor JJ, Yuan Q, Cook J et al (2013) Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. Nat Chem Biol 9:30–36

    Article  CAS  PubMed  Google Scholar 

  • Kelly ME, Ramkumar S, Sun W et al (2018) The biochemical basis of vitamin a production from the asymmetric carotenoid β-cryptoxanthin. ACS Chem Biol 13:2121–2129

    CAS  PubMed  PubMed Central  Google Scholar 

  • Khachik F, Goli MB, Beecher GR et al (1992) Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables. J Agric Food Chem 40:390–398

    CAS  Google Scholar 

  • Kim J, Kim H, Roh H et al (2018) Causes of hyperhomocysteinemia and its pathological significance. Arch Pharm Res 41:372–383

    CAS  PubMed  Google Scholar 

  • Kim HJ, Lee SK, Baek J et al (2019) Use of alitretinoin in moderate to severe chronic hand eczema: a real-world experience in Korea. Dermatol Ther 32:e12980

    PubMed  Google Scholar 

  • Kimura M, Itokawa Y, Fujiwara M (1990) Cooking losses of thiamin in food and its nutritional significance. J Nutr Sci Vitaminol 36:S17–S24

    PubMed  Google Scholar 

  • Kirsh VA, Hayes RB, Mayne ST et al (2006) Supplemental and dietary vitamin E, β-carotene, and vitamin C intakes and prostate cancer risk. J Natl Cancer Inst 98:245–254

    CAS  PubMed  Google Scholar 

  • Klein EA, Thompson IM, Tangen CM et al (2011) Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 306:1549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Klimant E, Wright H, Rubin D et al (2018) Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach. Curr Oncol 25:139

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kohls D, Sulea T, Purisima EO et al (2000) The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme. Structure 8:35–46

    CAS  PubMed  Google Scholar 

  • Kolhekar AS, Mains RE, Eipper BA (1997) [5] Peptidylglycine α-amidating monooxygenase: an ascorbate-requiring enzyme. Meth Enzymol 279:35–43.

    Google Scholar 

  • Kolli SS, Pecone D, Pona A et al (2019) Topical retinoids in acne vulgaris: a systematic review. Am J Clin Dermatol 20:345–365

    Article  PubMed  Google Scholar 

  • Kothari P, Tate A, Adewumi A et al (2020) The risk for scurvy in children with neurodevelopmental disorders. Spec Care Dentist 40:251–259

    Article  PubMed  Google Scholar 

  • Krebs HA, Hems R, Tyler B (1976) The regulation of folate metabolism. Biochem J 158:341–353

    Google Scholar 

  • Krishna U, Kamath SJ, Namath MK (2016) Management of Bitot’s spots. Eye Magazine, pp 35–36

    Google Scholar 

  • Kruk J, Szymańska R, Cela J et al (2014) Plastochromanol-8: fifty years of research. Phytochemistry 108:9–16

    Article  CAS  PubMed  Google Scholar 

  • Kryscio RJ, Abner EL, Caban-Holt A et al (2017) Association of antioxidant supplement use and dementia in the prevention of Alzheimer’s disease by vitamin E and selenium trial (PREADViSE). JAMA Neurol 74:567–573

    Article  PubMed  PubMed Central  Google Scholar 

  • Lacombe J, Ferron M (2018) VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues. Nutrients 10(8):970

    Article  PubMed Central  CAS  Google Scholar 

  • Lai KL, Ng JY, Srinivasan S (2014) Xerophthalmia and keratomalacia secondary to diet-induced vitamin A deficiency in Scottish adults. Can J Ophtalmol 49:109–112

    Article  Google Scholar 

  • Lanska DJ (2010) Historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. Handbook Clin Neurol 95:435–444

    Google Scholar 

  • Lazzerini Ospri L, Prusky G, Hattar S (2017) Mood, the circadian system, and melanopsin retinal ganglion cells. Annu Rev Neurosci 40:539–556

    Article  CAS  PubMed  Google Scholar 

  • Lee I-M, Cook NR, Gaziano JM et al (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer: the women’s health study: a randomized controlled trial. JAMA 294:56

    Article  CAS  PubMed  Google Scholar 

  • Lee NK, Sowa H, Hinoi E et al (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456–469

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee S, Choi Y, Jeong HS et al (2018) Effect of different cooking methods on the content of vitamins and true retention in selected vegetables. Food Sci Biotechnol 27:333–342

    CAS  PubMed  Google Scholar 

  • Leichter J, Switzer V, Landymore A (1978) Effect of cooking on folate content of vegetables. Nutr Rep Int 18:475–479

    CAS  Google Scholar 

  • Lemos C, Faria A, Meireles M et al (2012) Thiamine is a substrate of organic cation transporters in Caco-2 cells. Eur J Pharmacol 682:37–42

    Article  CAS  PubMed  Google Scholar 

  • Leng Y, Zhou H, Meng F et al (2019) Association of vitamin E on the risk of ovarian cancer: a meta-analysis. Biosc Rep BSR20193311

    Google Scholar 

  • Leuenberger MG, Engeloch-Jarret C, Woggon WD (2001) The reaction mechanism of the enzyme-catalyzed central cleavage of β-carotene to retinal. Angew Chem Int Ed 40:2614–2617

    Article  Google Scholar 

  • Levine M, Conry-Cantilena C, Wang Y et al (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93:3704–3709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li F-J, Shen L, Ji H-F (2012) Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer’s disease: a meta-analysis. J Alzheimers Dis 31:253–258

    Article  CAS  PubMed  Google Scholar 

  • Lian JB, Friedman PA (1978) The Vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes. J Biol Chem 253:6623–6626

    CAS  PubMed  Google Scholar 

  • Lin Y, Dueker SR, Follett JR et al (2004) Quantitation of in vivo human folate metabolism. Am J Clin Nutr 80:680–691

    Article  CAS  PubMed  Google Scholar 

  • Lin J-H, Chen S-J, Liu H et al (2019) Vitamin E consumption and the risk of bladder cancer. Int J Vitam Nutr Res 89:168–175

    Article  CAS  PubMed  Google Scholar 

  • Linster CL, Van Schaftingen E (2007) Vitamin C: biosynthesis, recycling and degradation in mammals. FEBS J 274:1–22

    Article  CAS  PubMed  Google Scholar 

  • Liu CS, Glahn RP, Liu RH (2004) Assessment of carotenoid bioavailability of whole foods using a Caco-2 cell culture model coupled with an in vitro digestion. J Agric Food Chem 52:4330–4337

    Article  CAS  PubMed  Google Scholar 

  • Liu M, Alimov AP, Wang H et al (2014) Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. Neuroscience 267:102–113

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Liu Y, Liu S et al (2019) Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients. Burns Trauma 7:13. https://doi.org/10.1186/s41038-019-0150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lobo GP, Hessel S, Eichinger A et al (2010) ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production. FASEB J 24:1656–1666

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lombardo D, Guy O (1980) Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters. Biochim Biophys Acta Enzymol 611:147–155

    Article  CAS  Google Scholar 

  • Long Y, Fei H, Xu S, et al (2019) Association about dietary vitamin C intake on the risk of ovarian cancer: a meta-analysis. Biosci Rep BSR20192385

    Google Scholar 

  • Lonn E, Bosch J, Yusuf S et al (2005) Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 293:1338–1347

    Article  PubMed  Google Scholar 

  • Lotan Y, Goodman PJ, Youssef RF et al (2012) Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT. J Urol 187:2005–2010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ložnjak P, Striegel L, Díaz de la Garza RI et al (2020) Quantification of folate in food using deconjugase of plant origin combined with LC-MS/MS: a method comparison of a large and diverse sample set. Food Chem 305:125450

    Article  PubMed  CAS  Google Scholar 

  • Lu’o’ng K, Nguyễn LTH (2013) The beneficial role of thiamine in Parkinson disease. CNS Neurosci Ther 19:461–468

    Article  CAS  Google Scholar 

  • Łukawski M, Dałek P, Borowik T et al (2019) New oral liposomal vitamin C formulation: properties and bioavailability. J Liposome Res:1–8

    Google Scholar 

  • Lykkesfeldt J, Tveden-Nyborg P (2019) The pharmacokinetics of vitamin C. Nutrients 11:2412

    Article  CAS  PubMed Central  Google Scholar 

  • Maeda N, Hagihara H, Nakata Y et al (2000) Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci USA 97:841–846

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Major LL, Wolucka BA, Naismith JH (2005) Structure and function of GDP-mannose-3′,5′-epimerase: an enzyme which performs three chemical reactions at the same active site. J Am Chem Soc 127:18309–18320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mangel N, Fudge JB, Fitzpatrick TB et al (2017) Vitamin B1 diversity and characterization of biosynthesis genes in cassava. J Exp Bot 68:3351–3363

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manolagas SC (2020) Osteocalcin promotes bone mineralization but is not a hormone. PLoS Genet 16:e1008714. https://doi.org/10.1371/journal.pgen.1008714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manzetti S, Zhang J, van der Spoel D (2014) Thiamin function, metabolism, uptake and transport. Biochemistry 53:821–835

    Article  CAS  PubMed  Google Scholar 

  • Marik PE, Liggett A (2019) Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders. Crit Care 23:165

    Article  PubMed  PubMed Central  Google Scholar 

  • Marlétaz F, Holland LZ, Laudet V et al (2006) Retinoic acid signaling and the evolution of chordates. Int J Biol Sci 2:38–47

    Article  PubMed  PubMed Central  Google Scholar 

  • Martí-Carvajal AJ, Solà I, Lathyris D et al (2017) Homocysteine-lowering interventions (B-complex vitamin therapy) for preventing cardiovascular events. Cochrane Database Syst Rev 8:CD006612

    PubMed  Google Scholar 

  • Mathias PM, Harries JT, Peters TJ et al (1981) Studies on the in vivo absorption of micellar solutions of tocopherol and tocopheryl acetate in the rat: demonstration and partial characterization of a mucosal esterase localized to the endoplasmic reticulum of the enterocyte. J Lipid Res 22:829–837

    CAS  PubMed  Google Scholar 

  • Matsumoto A, Mizukami H, Mizuno S et al (2007) β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem Pharmacol 74:256–264

    Article  CAS  PubMed  Google Scholar 

  • McBurney A, Shearer MJ, Barkhan P (1980) Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone) in man. Biochem Med 24:250–267

    Article  CAS  PubMed  Google Scholar 

  • McCoy RM, Utturkar SM, Crook JW et al (2018) The origin and biosynthesis of the naphthalenoid moiety of juglone in black walnut. Hort Res 5:67

    Google Scholar 

  • McGrane MM (2007) Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. J Nutr Biochem 18:497–508

    CAS  PubMed  Google Scholar 

  • McKenzie RE, Aldridge M, Paquin J (1980) The bifunctional enzyme formiminotransferase-cyclodeaminase is a tetramer of dimers. J Biol Chem 255:9474–9478

    Google Scholar 

  • McKillop DJ, McNulty H, Scott JM et al (2006) The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Am J Clin Nutr 84:167–173

    CAS  PubMed  Google Scholar 

  • McNulty H, Pentieva K (2009) Folate bioavailability. In: Bailey LB (ed) Folate in health and disease, 2nd edn. CRC Press, Boca Raton

    Google Scholar 

  • McPartlin J, Halligan A, Scott JM et al (1993) Accelerated folate breakdown in pregnancy. Lancet 341:148–149

    CAS  PubMed  Google Scholar 

  • Megarity CF, Gill JRE, Caraher MC et al (2014) The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties. FEBS Lett 588:1666–1672

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mène-Saffrané L, DellaPenna D (2010) Biosynthesis, regulation and functions of tocochromanols in plants. Plant Physiol Biochem 48:301–309

    PubMed  Google Scholar 

  • Menter A, Gelfand JM, Connor C et al (2020) Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. J Am Acad Dermatol 82:1445–1486

    CAS  PubMed  Google Scholar 

  • Menniti FS, Knoth J, Diliberto EJ (1986) Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration. J Biol Chem 261:16901–16908

    Google Scholar 

  • Meydani SN, Meydani M, Blumberg JB et al (1997) Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 277:1380–1386

    CAS  PubMed  Google Scholar 

  • Meydani SN, Meydani M, Blumberg JB et al (1998) Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults. Am J Clin Nutr 68:311–318

    CAS  PubMed  Google Scholar 

  • Meydani SN, Leka LS, Fine BC et al (2004) Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA 292:828

    CAS  PubMed  PubMed Central  Google Scholar 

  • Meyer Berger J, Singh P, Khrimian P et al (2019) Mediation of the acute stress response by the skeleton. Cell Metab 30:890–902

    Google Scholar 

  • Michalik L, Auwerx J, Berger JP et al (2006) International union of pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 58:726–741

    CAS  PubMed  Google Scholar 

  • Michelazzo FB, Oliveira JM, Stefanello J et al (2013) The influence of vitamin A supplementation on iron status. Nutrients 5:4399–4413

    PubMed  PubMed Central  Google Scholar 

  • Miller ER, Pastor-Barriuso R, Dalal D et al (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142:37–46

    CAS  PubMed  Google Scholar 

  • Miraglia N, Agostinetto M, Bianchi D et al (2016) Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol 68:99–105

    PubMed  Google Scholar 

  • Mittschke L, Parthier C, Schröder-Tittmann K et al (2010) The crystal structure of human transketolase and new insights into its mode of action. J Biol Chem 285:31559–31570

    Google Scholar 

  • Mizushima Y, Harauchi T, Yoshizaki T et al (1984) A rat mutant unable to synthesize vitamin C. Experientia 40:359–361

    CAS  PubMed  Google Scholar 

  • Mohan S, Kapoor A, Singgih A et al (2005) Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. J Bone Miner Res 20:1597–1610

    CAS  PubMed  Google Scholar 

  • Moore T (1930) LXXIX. Vitamin A and carotene. V. The absence of the liver oil vitamin A from carotene. VI. The conversion of carotene to vitamin A in vivo. Biochem J 24:692–702

    CAS  PubMed  PubMed Central  Google Scholar 

  • Moran GR (2005) 4-Hydroxyphenylpyruvate dioxygenase. Arch Biochem Biophys 433:117–128

    Google Scholar 

  • Mori S (1922) The changes in the para-ocular glands which follow the administration of diets low in fat-soluble A; with notes of the effect of the same diets on the salivary glands and the mucosa of the larynx and trachea. Bull Johns Hopkins Hosp 33:357–359

    CAS  Google Scholar 

  • Moriishi T, Ozasa R, Ishimoto T et al (2020) Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLoS Genet 16:e1008586

    CAS  PubMed  PubMed Central  Google Scholar 

  • Moriwaki H, Blaner WS, Piantedosi R et al (1988) Effects of dietary retinoid and triglyceride on the lipid-composition of rat-liver stellate cells and stellate cell lipid droplets. J Lipid Res 29:1523–1534

    CAS  PubMed  Google Scholar 

  • Moser MA, Chun OK (2016) Vitamin C and heart health: a review based on findings from epidemiologic studies. Int J Mol Sci 17:1328

    PubMed Central  Google Scholar 

  • Mouillon JM, Ravanel S, Douce R et al (2002) Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities. Biochem J 363:313–319

    CAS  PubMed  PubMed Central  Google Scholar 

  • MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338:131–137

    Google Scholar 

  • Mulligan JD, Flowers MT, Tebon A et al (2003) ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens. J Biol Chem 278:13356–13366

    CAS  PubMed  Google Scholar 

  • Muñoz P, Munné-Bosch S (2019) Vitamin E in plants: biosynthesis, transport, and function. Trends Plant Sci 24:1040–1051

    PubMed  Google Scholar 

  • Murphy RT, Foley JB, Tome M-T et al (2004) Vitamin E modulation of C-reactive protein in smokers with acute coronary syndromes. Free Rad Biol Med 36:959–965

    CAS  PubMed  Google Scholar 

  • Mustacich DJ, Leonard SW, Patel NK et al (2010) α-tocopherol β-oxidation localized to rat liver mitochondria. Free Radic Biol Med 48:73–81

    CAS  PubMed  Google Scholar 

  • Nabokina SM, Said HM (2012) A high-affinity and specific carrier-mediated mechanism for uptake of thiamine pyrophosphate by human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 303:G389–G395

    PubMed  PubMed Central  Google Scholar 

  • Nagy K, Ramos L, Courtet-Compondu M-C et al (2013) Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions. Eur J Clin Nutr 67:202–206

    CAS  PubMed  Google Scholar 

  • Nakagawa M, Tazawa Y, Kobayashi Y et al (1984) Familial intrahepatic cholestasis associated with progressive neuromuscular disease and vitamin E deficiency. J Pediatr Gastroenterol Nutr 3:385–389

    CAS  PubMed  Google Scholar 

  • Ncube TN, Greiner T, Malaba LC et al (2001) Supplementing lactating women with pureed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr 131:1497–1502

    CAS  PubMed  Google Scholar 

  • Nelsestuen GL, Suttie JW (1972) Mode of action of vitamin K. Calcium binding properties of bovine prothrombin. Biochemistry 11:4961–4964

    CAS  PubMed  Google Scholar 

  • Ngo B, Van Riper JM, Cantley LC, Yun J (2019) Targeting cancer vulnerabilities with high-dose vitamin C. Nat Rev Cancer 19:271–282

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nhieu J, Lin YL, Wei LN (2020) Noncanonical retinoic acid signaling. Meth Enzymol 637:261-281

    Google Scholar 

  • Niki E (2014) Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic Biol Med 66:3–12

    CAS  PubMed  Google Scholar 

  • Nursal B, Yücecan S (2000) Vitamin C losses in some frozen vegetables due to various cooking methods. Nahrung 44:451–453. https://doi.org/10.1002/1521-3803(20001201)44:6<451::AID-FOOD451>3.0.CO;2-5

    Article  CAS  PubMed  Google Scholar 

  • O’Brien JT, Holmes C, Jones M et al (2017) Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol 31:147–168

    PubMed  Google Scholar 

  • O’Byrne SM, Wongsiriroj N, Libien J et al (2005) Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem 280:35647–35657

    PubMed  Google Scholar 

  • O’Neil CA, Schwartz SJ (1995) Photoisomerization of .beta.-Carotene by Photosensitization with Chlorophyll Derivatives as Sensitizers. J Agr Food Chem 43(3):631-635

    Google Scholar 

  • Olson JM, Goyal A (2020) Vitamin A toxicity. StatPearls Publishing, StatPearls. Retrieved 29 May 2020, https://www.ncbi.nlm.nih.gov/books/NBK430685/)

  • Pacana T, Sanyal AJ (2012) Vitamin E and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metabol Care 15:641–648

    CAS  Google Scholar 

  • Paciolla C, Fortunato S, Dipierro N et al (2019) Vitamin C in plants: from functions to biofortification. Antioxidants 8:519

    CAS  PubMed Central  Google Scholar 

  • Padayatty SJ, Levine M (2016) Vitamin C: the known and the unknown and Goldilocks. Oral Dis 22:463–493

    CAS  PubMed  PubMed Central  Google Scholar 

  • Padayatty SJ, Sun H, Wang Y et al (2004) Vitamin C pharmacokinetics: implications for oral and intravenous Use. Ann Intern Med 140:533

    CAS  PubMed  Google Scholar 

  • Pae M, Wu D (2017) Nutritional modulation of age-related changes in the immune system and risk of infection. Nutr Res 41:14–35

    CAS  PubMed  Google Scholar 

  • Parrow NL, Leshin JA, Levine M (2013) Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antioxid Redox Signal 19:2141–2156

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pastore EJ, Friedkin M (1962) The enzymatic synthesis of thymidylate II. Transfer of tritium from tetrahydrofolate to the methyl group of thymidylate. J Biol Chem 237:3802–3810

    CAS  PubMed  Google Scholar 

  • Patel KR, Sobczyńska-Malefora A (2017) The adverse effects of an excessive folate intake. Eur J Clin Nutr 71:159–163

    CAS  PubMed  Google Scholar 

  • Pawson BA (1982) History of retinoids. J Am Acad Dermatol 6:577–582

    CAS  PubMed  Google Scholar 

  • Pédeboscq S, Rey C, Petit M et al (2012) Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. PLoS One 7:e36811

    PubMed  PubMed Central  Google Scholar 

  • Pepperberg DR, Okajima TL, Wiggert B et al (1993) Interphotoreceptor retinoid-binding protein (IRBP). Molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol 7:61–85

    CAS  PubMed  Google Scholar 

  • Peterson JW, Muzzey KL, Haytowitz D et al (2002) Phylloquinone (vitamin K1) and dihydrophylloquinone content of fats and oils. J Am Oil Chem Soc 79:641–646

    CAS  Google Scholar 

  • Pesek CA, Warthesen JJ, Taoukis PS (1990) A kinetic model for equilibration of isomeric ß-carotenes. J Agric Food Chem 38:41–45

    Google Scholar 

  • Pfeiffer CM, Fazili Z, Zhang M (2009) Folate analytical methodology. In: Bailey LB (ed) Folate in health and disease, 2nd edn. CRC Press, Boca Raton, pp 517–574

    Google Scholar 

  • Piironen V, Varo P, Koivistoinen P (1987) Stability of tocopherols and tocotrienols in food preparation procedures. J Food Compos Anal 1:53–58

    Article  CAS  Google Scholar 

  • Podszun M, Frank J (2014) Vitamin E–drug interactions: molecular basis and clinical relevance. Nutr Res Rev 27:215–231

    Article  CAS  PubMed  Google Scholar 

  • Prakash S (2018) Gastrointestinal beriberi: a forme fruste of Wernicke’s encephalopathy? BMJ Case Rep. https://doi.org/10.1136/bcr-2018-224841

  • Preusch PC, Smalley DM (1990) Vitamin K, 2,3-epoxide and quinone reduction: mechanism and inhibition. Free Radic Res Commun 8:401–415

    Article  CAS  PubMed  Google Scholar 

  • Price PA, Otsuka AA, Poser JW et al (1976) Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci USA 73:1447–1451

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prigge ST, Kolhekar AS, Eipper BA et al (1999) Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. Nat Struct Biol 6:976–983

    Article  CAS  PubMed  Google Scholar 

  • Prigge ST, Mains RE, Eipper BA, Amzel LM (2000) New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. Cell Mol Life Sci 57:1236–1259

    Article  CAS  PubMed  Google Scholar 

  • Pullar JM, Carr AC, Vissers MCM (2017) The roles of vitamin C in skin health. Nutrients 9:866

    Article  PubMed Central  CAS  Google Scholar 

  • Putzu A, Daems A-M, Lopez-Delgado JC et al (2019) The effect of vitamin C on clinical outcome in critically Ill patients: a systematic review with meta-analysis of randomized controlled trials. Crit Care Med 47:774–783

    Article  PubMed  Google Scholar 

  • Ram J, Jinagal J (2018) Bitot’s spots. New Engl J Med 379:869

    Article  PubMed  Google Scholar 

  • Ravanel S, Cherest H, Jabrin S et al (2001) Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Proc Natl Acad Sci USA 98:15360–15365

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rebouche CJ (1991a) Ascorbic acid and carnitine biosynthesis. Am J Clin Nutr 54(6):1147S–1152S

    Google Scholar 

  • Rebouche CJ (1991b) Quantitative estimation of absorption and degradation of a carnitine supplement by human adults. Metabolism 40(12):1305–1310

    Google Scholar 

  • Rebouche CJ (1995) The ability of guinea pigs to synthesize carnitine at a normal rate from epsilon-N-trimethyllysine or gamma-butyrobetaine in vivo is not compromised by experimental vitamin C deficiency. Metab Clin Exp 44:624–629

    Google Scholar 

  • Reboul E (2013) Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins. Nutrients 5:3563–3581

    PubMed  PubMed Central  Google Scholar 

  • Reboul E (2017) Vitamin E bioavailability: mechanisms of intestinal absorption in the spotlight. Antioxidants 6:95

    PubMed Central  Google Scholar 

  • Reboul E (2019a) Mechanisms of carotenoid intestinal absorption: where do we stand? Nutrients 11:838. https://doi.org/10.3390/nu11040838

    Article  CAS  PubMed Central  Google Scholar 

  • Reboul E (2019b) Vitamin E intestinal absorption: regulation of membrane transport across the enterocyte: vitamin E membrane transport in the enterocyte. IUBMB Life 71:416–423

    CAS  PubMed  Google Scholar 

  • Reumann S (2013) Biosynthesis of Vitamin K1 (Phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways. In: del Rio LA (ed) Peroxisomes and their key role in cellular signaling and metabolism, Subcellular biochemistry, vol 69. Springer, Dordrecht, pp 213–229

    Google Scholar 

  • Rigotti A (2007) Absorption, transport, and tissue delivery of vitamin E. Mol Asp Med 28:423–436

    Article  CAS  Google Scholar 

  • Rindi G, Ricci V, Gastaldi G et al (1995) Intestinal alkaline phosphatase can transphosphorylate thiamin to thiamin monophosphate during intestinal transport in the rat. Arch Physiol Biochem 103:33–38

    CAS  PubMed  Google Scholar 

  • Rishavy MA, Hallgren KW, Yakubenko AV et al (2006) Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation. Biochemistry 45:13239–13248

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Amaya DB, Tavares CA (1992) Importance of cis-isomer separation in determining provitamin A in tomato and tomato products. Food Chem 45:297–302

    Article  CAS  Google Scholar 

  • Roecklein KA, Rohan KJ, Duncan WC et al (2009) A missense variant (P10L) of the melanopsin (Opn4) gene is associated with seasonal affective disorder. J Affect Disord 114:279–285

    Article  CAS  PubMed  Google Scholar 

  • Roecklein KA, Wong PM, Franzen PL et al (2012) Melanopsin gene variations interact with season to predict sleep onset and chronotype. Chronobiol Int 29:1036–1047

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roje S (2007) Vitamin B biosynthesis in plants. Phytochemistry 68:1904–1921

    Article  CAS  PubMed  Google Scholar 

  • Rühl R, Krzyżosiak A, Niewiadomska-Cimicka A et al (2015) 9-cis-13,14-dihydroretinoic acid is an endogenous retinoid acting as RXR ligand in mice. PLoS Genet 11(6):e1005213. https://doi.org/10.1371/journal.pgen.1005213

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rutjes AW, Denton DA, Di Nisio M et al (2018) Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Cochrane Database Syst Rev 12:CD011906

    PubMed  Google Scholar 

  • Saari J (2012) Vitamin A metabolism in rod and cone visual cycles. Annu Rev Nutr 32:125–145

    Article  CAS  PubMed  Google Scholar 

  • Saboori S, Shab-Bidar S, Speakman JR et al (2015) Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials. Eur J Clin Nutr 69:867–873

    Article  CAS  PubMed  Google Scholar 

  • Sahr T, Ravanel S, Basset G et al (2006) Folate biosynthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase. Biochem J 396:157–162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Said A, Akhter A (2017) Meta-analysis of randomized controlled trials of pharmacologic agents in non-alcoholic steatohepatitis. Ann Hepatol 16:538–547

    Article  CAS  PubMed  Google Scholar 

  • Said H, Balamurugan K, Subramanian VS et al (2004) Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol 286:G491–G498

    Article  CAS  PubMed  Google Scholar 

  • Sanyal AJ, Chalasani N, Kowdley KV et al (2010) Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 362:1675–1685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sato S, Kefalov VJ (2016) Cis retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration. J Physiol 594:6753–6765

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sato K, Gosho M, Yamamoto T et al (2015) Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Nutrition 31:923–930

    Article  CAS  PubMed  Google Scholar 

  • Sauberlich HE (1967) Biochemical alterations in thiamine deficiency – their interpretation. Am J Clin Nutr 20:528–542

    Article  CAS  PubMed  Google Scholar 

  • Scaglione F, Panzavolta G (2014) Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica 44:480–488

    Article  CAS  PubMed  Google Scholar 

  • Schaller K, Höller H (1975) Thiamine absorption in the rat. II. Intestinal alkaline phosphatase activity and thiamine absorption from rat small intestine in-vitro and in-vivo. Int J Vitam Nutr Res 45:30–38

    CAS  PubMed  Google Scholar 

  • Schmölz L (2016) Complexity of vitamin E metabolism. World J Biol Chem 7:14–43

    Article  PubMed  PubMed Central  Google Scholar 

  • Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49:7–30

    Article  CAS  PubMed  Google Scholar 

  • Schug T, Berry DC, Shaw NS et al (2007) Dual transcriptional activities underlie opposing effects of retinoic acid on cell survival. Cell 129:723–733

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schwab S, Zierer A, Schneider A et al (2015) Vitamin E supplementation is associated with lower levels of C-reactive protein only in higher dosages and combined with other antioxidants: the cooperative health research in the region of Augsburg (KORA) F4 study. Br J Nutr 113:1782–1791

    Article  CAS  PubMed  Google Scholar 

  • Scientific Committee for Food (SCF) (1993) Nutrient and energy intakes for the European Community. Reports of the Scientific Committee for Food, 31st Series. SCF, Luxembourg

    Google Scholar 

  • Sears AE, Palczewski K (2016) Lecithin:retinol acyltransferase: a key enzyme involved in the retinoid (visual) cycle. Biochemistry 55:3083–3091

    Article  CAS  Google Scholar 

  • Shafizadeh TB, Halsted CH (2007) γ-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine. J Nutr 137:1149–1153

    Article  CAS  PubMed  Google Scholar 

  • Shea MK, Barger K, Booth SL et al (2020) Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts. Am J Clin Nutr 111:1170–1177

    Article  PubMed  PubMed Central  Google Scholar 

  • Shearer MJ, Newman P (2014) Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis. J Lipid Res 55:345–362

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shearer MJ, McBurney A, Barkhan P (1974) Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man. Vitam Horm 32:513–542

    Article  CAS  PubMed  Google Scholar 

  • Shearer MJ, Fu X, Booth SL (2012) Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr 3:182–195

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shen C, Huang Y, Yi S et al (2015) Association of Vitamin E intake with reduced risk of kidney cancer: a meta-analysis of observational studies. Med Sci Monit 21:3420–3426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shi R, Li Z-H, Chen D et al (2018) Sole and combined vitamin C supplementation can prevent postoperative atrial fibrillation after cardiac surgery: a systematic review and meta-analysis of randomized controlled trials. Clin Cardiol 41:871–878

    PubMed  PubMed Central  Google Scholar 

  • Shimada H, Ohno R, Shibata M et al (2005) Inactivation and deficiency of core proteins of photosystems I and II caused by genetical phylloquinone and plastoquinone deficiency but retained lamellar structure in a T-DNA. Plant J 41:627–637

    CAS  PubMed  Google Scholar 

  • Shohag MJI, Yang Q, Wei Y et al (2017) A rapid method for sensitive profiling of folates from plant leaf by ultra-performance liquid chromatography coupled to tandem quadrupole mass spectrometer. J Chromatogr B 1040:169–179

    CAS  Google Scholar 

  • Silverman RB, Nandi DL (1988) Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide. Biochem Biophys Res Commun 155:1248–1254

    CAS  PubMed  Google Scholar 

  • Simon A, Hellman U, Wernstedt C et al (1995) The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. J Biol Chem 270:1107–1112

    CAS  PubMed  Google Scholar 

  • Singh U, Jialal I (2004) Anti-inflammatory effects of α-tocopherol. Ann NY Acad Sci 1031:195–203

    CAS  PubMed  Google Scholar 

  • Słupski J, Lisiewska Z (2013) Tocopherol retention and vitamin E activity in frozen and canned immature seeds of five cultivars of common bean: tocopherol in immature seeds of common bean. J Sci Food Agric 93:1326–1330

    PubMed  Google Scholar 

  • Smirnoff N (2018) Ascorbic acid metabolism and functions: a comparison of plants and mammals. Free Radic Biol Med 122:116–129

    CAS  PubMed  PubMed Central  Google Scholar 

  • Smirnoff N, Wheeler GL (2000) Ascorbic acid in plants: biosynthesis and function. Crit Rev Biochem Mol Biol 35:291–314

    CAS  PubMed  Google Scholar 

  • Sokol RJ, Guggenheim MA, Heubi JE et al (1985) Frequency and clinical progression of the vitamin E deficiency neurologic disorder in children with prolonged neonatal cholestasis. Am J Dis Child 139:1211–1215

    CAS  PubMed  Google Scholar 

  • Sommer A (1998) Xerophtalmia and vitamin A status. Prog Retin Eye Res 17:9–31

    CAS  PubMed  Google Scholar 

  • Son Y-S, Ullah HMA, Elfadl AK et al (2018) Preventive effects of vitamin C on diethylnitrosamine-induced hepatotoxicity in Smp30 knockout mice. In Vivo 32:93–99

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stenflo J, Fernlund P, Egan W et al (1974) Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc Nat Acad Sci USA 71:2730–2733

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stites TE, Bailey LB, Scott KC et al (1997) Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am J Clin Nutr 65:53–60

    CAS  PubMed  Google Scholar 

  • Sun T, Yuan H, Cao H et al (2018) Carotenoid metabolism in plants: the role of plastids. Mol Plant 11:58–74

    PubMed  Google Scholar 

  • Takada T, Yamanashi Y, Konishi K et al (2015) NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Sci Transl Med 7:275ra23

    CAS  PubMed  Google Scholar 

  • Tallaksen CME, Sande A, Bøhmer T et al (1993) Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Eur J Clin Pharmacol 44:73–78

    CAS  PubMed  Google Scholar 

  • Tarento TDC, McClure DD, Vasilijevski E et al (2018) Microalgae as a source of vitamin K1. Algal Res 36:77–87

    Google Scholar 

  • Tarento TDC, McClure DD, Talbot AM et al (2019) A potential biotechnological process for the sustainable production of vitamin K1. Crit Rev Biotechnol 39:1–19

    CAS  PubMed  Google Scholar 

  • Tarwadi K, Agte V (2007) Antioxidant and micronutrient potential of common fruits available in the Indian subcontinent. Int J Food Sci Nutr 58:341–349

    CAS  PubMed  Google Scholar 

  • Tasinato A, Boscoboinik D, Bartoli GM et al (1995) d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci USA 92:12190–12194

    CAS  PubMed  PubMed Central  Google Scholar 

  • Taylor HR, Tikellis G, Robman LD et al (2002) Vitamin E supplementation and macular degeneration: randomised controlled trial. BMJ 325:11

    CAS  PubMed  PubMed Central  Google Scholar 

  • Terasawa Y, Ladha Z, Leonard SW et al (2000) Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci USA 97:13830–13834

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tomasulo PA, Kater RMH, Iber FL (1968) Impairment of thiamine absorption in alcoholism. Am J Clin Nutr 21:1340–1344

    Google Scholar 

  • Traber MG, Atkinson J (2007) Vitamin E, antioxidant and nothing more. Free Radic Biol Med 43:4–15

    CAS  PubMed  PubMed Central  Google Scholar 

  • Traber MG, Stevens JF (2011) Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med 51:1000–1013

    CAS  PubMed  PubMed Central  Google Scholar 

  • Travica N, Ried K, Sali A et al (2017) Vitamin C status and cognitive function: a systematic review. Nutrients 9:960

    PubMed Central  Google Scholar 

  • Tri Hoang M, Yau KW (2010) Intrinsically photosensitive retinal ganglion cells. Physiol Rev 90:1547–1581

    Google Scholar 

  • Tsou P, Wu C-J (2019) Serum vitamin E levels of adults with nonalcoholic fatty liver disease: an inverse relationship with all-cause mortality in non-diabetic but not in pre-diabetic or diabetic subjects. J Clin Med 8:1057

    CAS  PubMed Central  Google Scholar 

  • Turley SD, West CE, Horton BJ (1976) The role of ascorbic acid in the regulation of cholesterol metabolism and in the pathogenesis of artherosclerosis. Atherosclerosis 24:1–18

    CAS  PubMed  Google Scholar 

  • Ueda S, Yasunari K (2006) What we learnt from randomized clinical trials and cohort studies of antioxidant vitamin? Focus on vitamin E and cardiovascular disease. Curr Pharm Biotechnol 7:69–72

    CAS  PubMed  Google Scholar 

  • Ulatowski L, Parker R, Warrier G et al (2014) Vitamin E is essential for Purkinje neuron integrity. Neuroscience 260:120–129

    CAS  PubMed  Google Scholar 

  • Urbanski U, Frank J, Neumann NJ (2016) Erythropoetische protoporphyrie. Klinik, diagnostik und neue therapeutische möglichkeiten. Der Hautarzt 67:211–215

    CAS  PubMed  Google Scholar 

  • Urueña-Palacio S, Ferreyro BL, Fernández-Otero LG et al (2018) Adult scurvy associated with psychiatric disorders and breast feeding. BMJ Case Rep 2018:bcr2017223686

    PubMed Central  Google Scholar 

  • USDA (2020) Food data central. https://fdc.nal.usda.gov/. Updated 2019, consulted 1 May 2020

  • Valpuesta V, Botella MA (2004) Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant. Trends Plant Sci 9:573–577

    Google Scholar 

  • van Bennekum A, Werder M, Thuahnai ST et al (2005) Class B scavenger receptor-mediated intestinal absorption of dietary β-carotene and cholesterol. Biochemistry 44:4517–4525

    PubMed  Google Scholar 

  • Vandenbroucke JP (2013) Adolphe Vorderman’s 1897 study on beriberi: an example of scrupulous efforts to avoid bias. J R Soc Med 106:108–111

    PubMed  PubMed Central  Google Scholar 

  • Ventura A, Mafe MC, Bourguet M et al (2013) Encefalopatía de Wernicke secundaria a hipertiroidismo e ingesta de productos ricos en tiaminasas. Neurologia 28:257–259

    CAS  PubMed  Google Scholar 

  • Verlinde PHCJ, Oey I, Lemmens L et al (2010) Influence of reducing carbohydrates on (6S)-5-methyltetrahydrofolic acid degradation during thermal treatments. J Agric Food Chem 58:6190–6199

    CAS  PubMed  Google Scholar 

  • Vervoort L, Grauwet T, Njoroge DM et al (2013) Comparing thermal and high pressure processing of carrots at different processing intensities by headspace fingerprinting. Innov Food Sci Emerg Technol 18:31–42

    CAS  Google Scholar 

  • Vidal (2013) Ascorbic acid. https://www.vidal.fr/substances/26/acide_ascorbique/. Updated 16 Jan 2013, consulted 1 May 2020

  • Vidal (2016) Alpha-tocopherol. https://www.vidal.fr/substances/245/alpha_tocopherol/. Updated 16 Jan 2013, consulted 1 May 2020

  • Vijayaraghavan K, Sarma KV, Rao NP et al (1984) Impact of massive doses of vitamin A on incidence of nutritional blindness. Lancet 2:149–151

    CAS  PubMed  Google Scholar 

  • Vissers MCM, Das AB (2018) Potential mechanisms of action for vitamin C in cancer: reviewing the evidence. Front Physiol 9:809

    PubMed  PubMed Central  Google Scholar 

  • vom Dorp K, Hölzl G, Plohmann C et al (2015) Remobilization of phytol from chlorophyll degradation is essential for tocopherol synthesis and growth of arabidopsis. Plant Cell tpc.15.00395. https://doi.org/10.1105/tpc.15.00395

  • Vorilhon P, Arpajou B, Vaillant Roussel H et al (2019) Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. Eur J Clin Pharmacol 75:303–311

    CAS  PubMed  Google Scholar 

  • Vuong LT, Dueker SR, Murphy SP (2002) Plasma beta-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit momordica cochinchinensis (gac). Am J Clin Nutr 75:872–879

    CAS  Google Scholar 

  • Wadhwani M, Singh R (2020) Bilateral keratomalacia leading to blindness secondary to diet-induced vitamin A deficiency in infants. J Pediatr Ophtalmol Strabismus 57:e12–e14

    Google Scholar 

  • Wahba AJ, Friedkin M (1961) Direct spectrophotometric evidence for the oxidation of tetrahydrofolate during the enzymatic synthesis of thymidylate. J Biol Chem 236:PC11–PC12

    CAS  PubMed  Google Scholar 

  • Wallin R, Wajih N, Hutson SM (2008) VKORC1: a Warfarin-sensitive enzyme in vitamin K metabolism and biosynthesis of vitamin K-dependent blood coagulation factors. Vitam Horm 78:227–246

    CAS  PubMed  Google Scholar 

  • Wang JS, Kefalov VJ (2009) An alternative pathway mediates the mouse and human cone visual cycle. Curr Biol 19:1665–1669

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang TTY, Chandler CJ, Halsted CH (1986) Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. J Biol Chem 261:13551–13555

    CAS  PubMed  Google Scholar 

  • Wang Y-Y, Wang X-L, Yu Z-J (2014) Vitamin C and E intake and risk of bladder cancer: a meta-analysis of observational studies. Int J Clin Exp Med 7:4154–4164

    PubMed  PubMed Central  Google Scholar 

  • Watkins J, Pogson BJ (2020) Prospects for carotenoid biofortification targeting retention and catabolism. Trends Plant Sci 25:501–512

    CAS  PubMed  Google Scholar 

  • Wheeler GL, Jones MA, Smirnoff N (1998) The biosynthetic pathway of vitamin C in higher plants. Nature 393:365

    CAS  PubMed  Google Scholar 

  • Whitfield KC, Bourassa MW, Adamolekum B et al (2018) Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann NY Acad Sci 1430:3–43

    Google Scholar 

  • WHO (2017) Diarrhoeal disease fact sheet https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease. Retrieved 22 May 2020

  • Williams RR, Waterman RE, Gurin S (1930) The Jansen and Donath procedure for the isolation of antimeuritic vitamin. J Biol Chem 87:559–579

    CAS  Google Scholar 

  • Wills L (1933) A note on the use of marmite in tropical macrocytic anaemia, including pernicious anaemia of pregnancy. Ind Med Gaz 68:133–134

    PubMed  PubMed Central  Google Scholar 

  • Wilson MK, Baguley BC, Wall C et al (2014) Review of high-dose intravenous vitamin C as an anticancer agent. Asia Pac J Clin Oncol 10:22–37

    PubMed  Google Scholar 

  • Wolbach SB, Howe PR (1925) Tissue changes following deprivation of fat-soluble A vitamin. J Exp Med 42:753–777

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wolf G (2005) Function of the protein RPE65 in the visual cycle. Nutr Rev 63:97–100

    PubMed  Google Scholar 

  • Wongsiriroj N, Piantedosi R, Palczewski K et al (2008) The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem 283:13510–13519

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wood B, Gijsbers A, Goode A et al (1980) A study of partial thiamin restriction in human volunteers. Am J Clin Nutr 33:848–861

    CAS  PubMed  Google Scholar 

  • Wu D, Meydani SN (2014) Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocr Metab Immune Disord Drug Targets 14:283–289

    CAS  PubMed  Google Scholar 

  • Wu K, Willett WC, Chan JM et al (2002) A prospective study on supplemental vitamin E intake and risk of colon cancer in women and men. Cancer Epidemiol Biomarkers Prev 11:1298–1304

    CAS  PubMed  Google Scholar 

  • Yamanashi Y, Takada T, Kurauchi R et al (2017) Transporters for the intestinal absorption of cholesterol, vitamin E, and vitamin K. J Atheroscler Thromb 24:347–359

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yan AC, Jen MV (2012) Skin Signs of Pediatric Nutritional Disorders. Curr Probl Pediatr Adolesc Health Care 42:212–217

    PubMed  Google Scholar 

  • Yang W, Cahoon RE, Hunter SC et al (2011) Vitamin E biosynthesis: functional characterization of the monocot homogentisate geranylgeranyl transferase: Vitamin E biosynthesis: monocot HGGT. Plant J 65:206–217

    CAS  PubMed  Google Scholar 

  • Yokota T, Igarashi K, Uchihara T et al (2001) Delayed-onset ataxia in mice lacking -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci USA 98:15185–15190

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yoshida M, Hishiyama T, Ogawara M et al (2012) A novel method for determining vitamin B1 in a wide variety of foodstuffs with or without polyphenols. Food Chem 135:2387–2392

    CAS  PubMed  Google Scholar 

  • Yossa Nzeuwa IB, Guo B, Zhang T et al (2019) Comparative metabolic profiling of lycium fruits (Lycium barbarum and Lycium chinense) from different areas in China and from Nepal. J Food Qual 2019:1–6

    Google Scholar 

  • Zechmeister L (1949) Stereoisomeric provitamin A. Vitam Horm 7:57–81

    Article  CAS  Google Scholar 

  • Zhao R, Gao F, Goldman D (2002) Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol 282:C1512–C1517

    Article  CAS  PubMed  Google Scholar 

  • Zhao R, Matherly LH, Goldman ID (2009) Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 11:e4. https://doi.org/10.1017/S1462399409000969

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhao C, Liu Y, Lai S et al (2019) Effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals. Trends Food Sci Technol 85:55–66

    Article  CAS  Google Scholar 

  • Zingg J-M (2007) Modulation of signal transduction by vitamin E. Mol Asp Med 28:481–506

    Article  CAS  Google Scholar 

  • Zingg J-M (2015) Vitamin E: a role in signal transduction. Annu Rev Nutr 35:135–173

    Article  CAS  PubMed  Google Scholar 

  • Zingg J-M (2019) Vitamin E: regulatory role on signal transduction. IUBMB Life 71:456–478

    Article  CAS  PubMed  Google Scholar 

  • Zou Y, Duan H, Li L, Chen X et al (2019) Quantification of polyglutamyl 5-methyltetrahydrofolate, monoglutamyl folate vitamers, and total folates in different berries and berry juice by UHPLC–MS/MS. Food Chem 276:1–8

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by European Union, French State, and the Region of Hauts-de-France (CPER/FEDER Alibiotech).

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Rivière, C., Hennebelle, T. (2020). Plant Kingdom as Source of Vitamins. In: Xiao, J., Sarker, S.D., Asakawa, Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. https://doi.org/10.1007/978-981-13-1745-3_27-1

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