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Entry and Deposit of Aluminum in the Brain

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Neurotoxicity of Aluminum

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1091))

Abstract

Aluminum, as a known neurotoxicant, contributes to cognitive dysfunction and may contribute to Alzheimer’s disease. The important reason is that aluminum can enter and be deposited in the brain. There have been three routes by which aluminum could enter the brain from systemic circulation or the site of absorption. Aluminum fluxes into brain across the blood-brain barrier (BBB), the choroid plexuses and the nasal cavity. Some factors, such as the increasing of the blood-brain barrier permeability, citric acid and parathyroid hormone (PTH), and vitamin D, can promote aluminum to enter the brain. But the redistribution of aluminum out of the brain is slow, so aluminum can be deposited in the brain for a long time.

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Authors and Affiliations

  1. Shanxi Medical University, Taiyuan, People’s Republic of China

    Linping Wang

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  1. Linping Wang
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Correspondence to Linping Wang .

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Editors and Affiliations

  1. Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China

    Qiao Niu

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Wang, L. (2018). Entry and Deposit of Aluminum in the Brain. In: Niu, Q. (eds) Neurotoxicity of Aluminum. Advances in Experimental Medicine and Biology, vol 1091. Springer, Singapore. https://doi.org/10.1007/978-981-13-1370-7_3

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