Abstract
Endophytes are a range of microorganisms which inhabit the plant tissues, establishing an association with their hosts during a period for nearly or all their life without causing any apparent damage. It is known that some of these microorganisms have the potential to produce a diverse range of molecules that may be a reservoir of pharmaceutical drugs with anticancer activity. Cancer is a major trouble public health in all countries of the world, and this disease has higher mortality rate. Cancer is a name given to a complex disease, which is distinguished by the development and expansion of untypical cells and can lead to death. Nowadays the multidrug resistance (MDR) in cancer chemotherapy, remains a challenge to human and animal health around the world, which in several cases makes treatment inefficient. As a result, an increased number of strategies have been encouraged in search of MDR modulators (drugs that overcome MDR capacity) from various natural resources including endophyte-derived compounds. Thus, the aim of this chapter is to present the current status of several strategies adopted to promote the identification of some of these bioactive endophyte-derived compounds such as flavonoids, coumarins, polysaccharides, and β-glucans and to demonstrate their pharmaceutical potential as MDR modulators.
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Filho, J.A.C. (2018). Endophytic Microbes as a Novel Source for Producing Anticancer Compounds as Multidrug Resistance Modulators. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Natural Products and Biotechnological Implements. Springer, Singapore. https://doi.org/10.1007/978-981-10-8064-7_15
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