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TRPC Channels in Health and Disease

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Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

Abstract

This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung. The chapter highlights on cellular functions and signaling pathways mediated by TRPC channels. It also summarizes several inherited diseases in humans that are related to or caused by TRPC channel mutations and malfunction. A better understanding of TRPC channels functions and the importance of TRPC channels in health and disease should lead to new insights and discovery of new therapeutic approaches for intractable disease.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA

    Yilin Tai

  2. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, 100039, China

    Shenglian Yang, Yong Liu & Wei Shao

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  1. Yilin Tai
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  2. Shenglian Yang
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  3. Yong Liu
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  4. Wei Shao
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Correspondence to Yilin Tai or Shenglian Yang .

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  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

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Tai, Y., Yang, S., Liu, Y., Shao, W. (2017). TRPC Channels in Health and Disease. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_4

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