Skip to main content
SpringerLink
Log in

TRPC Channel Structure and Properties

  • Chapter
  • First Online:
Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

Abstract

TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+. The properties and the functional domains of TRPC channels have been identified by electrophysiological and biochemical methods. However, due to the large size, instability, and flexibility of their complexes, the structures of the members in TRPC family remain unrevealed. More efforts should be made on structure analysis and generating good tools, including specific antibodies, agonist, and antagonist.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Acharya JK, Jalink K, Hardy RW, Hartenstein V, Zuker CS (1997) InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron 18(6):881–887

    Article  CAS  PubMed  Google Scholar 

  2. Amiri H, Schultz G, Schaefer M (2003) FRET-based analysis of TRPC subunit stoichiometry. Cell Calcium 33(5–6):463–470

    Article  CAS  PubMed  Google Scholar 

  3. Anderson M, Kim EY, Hagmann H, Benzing T, Dryer SE (2013) Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol 305(3):C276–C289. doi:10.1152/ajpcell.00095.2013

    Article  CAS  PubMed  Google Scholar 

  4. Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavalie A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V (2013) Conserved gating elements in TRPC4 and TRPC5 channels. J Biol Chem 288(27):19471–19483. doi:10.1074/jbc.M113.478305

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E, Birnbaumer L (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem 272(47):29672–29680

    Article  CAS  PubMed  Google Scholar 

  6. Chang Q, Gyftogianni E, van de Graaf SF, Hoefs S, Weidema FA, Bindels RJ, Hoenderop JG (2004) Molecular determinants in TRPV5 channel assembly. J Biol Chem 279(52):54304–54311. doi:10.1074/jbc.M406222200

    Article  CAS  PubMed  Google Scholar 

  7. Clapham DE, Runnels LW, Strubing C (2001) The TRP ion channel family. Nat Rev Neurosci 2(6):387–396. doi:10.1038/35077544

    Article  CAS  PubMed  Google Scholar 

  8. Cordero-Morales JF, Gracheva EO, Julius D (2011) Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A 108(46):E1184–E1191. doi:10.1073/pnas.1114124108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Engelke M, Friedrich O, Budde P, Schafer C, Niemann U, Zitt C, Jungling E, Rocks O, Luckhoff A, Frey J (2002) Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta. FEBS Lett 523(1-3):193–199

    Article  CAS  PubMed  Google Scholar 

  10. Erler I, Al-Ansary DM, Wissenbach U, Wagner TF, Flockerzi V, Niemeyer BA (2006) Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281(50):38396–38404. doi:10.1074/jbc.M607756200

    Article  CAS  PubMed  Google Scholar 

  11. Erler I, Hirnet D, Wissenbach U, Flockerzi V, Niemeyer BA (2004) Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem 279(33):34456–34463. doi:10.1074/jbc.M404778200

    Article  CAS  PubMed  Google Scholar 

  12. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (2006) A mutation in orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441(7090):179–185. doi:10.1038/nature04702

    Article  CAS  PubMed  Google Scholar 

  13. Fujiwara Y, Minor DL Jr (2008) X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol 383(4):854–870. doi:10.1016/j.jmb.2008.08.059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Garcia-Sanz N, Fernandez-Carvajal A, Morenilla-Palao C, Planells-Cases R, Fajardo-Sanchez E, Fernandez-Ballester G, Ferrer-Montiel A (2004) Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci: Off J Soc Neurosci 24(23):5307–5314. doi:10.1523/JNEUROSCI.0202-04.2004

    Article  CAS  Google Scholar 

  15. Gaudet R (2007) Structural insights into the function of TRP channels. In: Liedtke WB, Heller S (eds) TRP ion channel function in sensory transduction and cellular signaling cascades, Frontiers in neuroscience. CRC Press, Boca Raton

    Google Scholar 

  16. Gaudet R (2008) TRP channels entering the structural era. J Physiol 586(15):3565–3575. doi:10.1113/jphysiol.2008.155812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Gillo B, Chorna I, Cohen H, Cook B, Manistersky I, Chorev M, Arnon A, Pollock JA, Selinger Z, Minke B (1996) Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry. Proc Natl Acad Sci U S A 93(24):14146–14151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Grisshammer R (2006) Understanding recombinant expression of membrane proteins. Curr Opin Biotechnol 17(4):337–340. doi:10.1016/j.copbio.2006.06.001

    Article  CAS  PubMed  Google Scholar 

  19. Harteneck C (2003) Proteins modulating TRP channel function. Cell Calcium 33(5–6):303–310

    Article  CAS  PubMed  Google Scholar 

  20. Harteneck C, Plant TD, Schultz G (2000) From worm to man: three subfamilies of TRP channels. Trends Neurosci 23(4):159–166

    Article  CAS  PubMed  Google Scholar 

  21. Hellmich UA, Gaudet R (2014) Structural biology of TRP channels. Handb Exp Pharmacol 223:963–990. doi:10.1007/978-3-319-05161-1_10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hellwig N, Albrecht N, Harteneck C, Schultz G, Schaefer M (2005) Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci 118(Pt 5):917–928. doi:10.1242/jcs.01675

    Article  CAS  PubMed  Google Scholar 

  23. Hilgemann DW, Feng S, Nasuhoglu C (2001) The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE: Sig Transduct Knowl Environ 2001(111):re19. doi:10.1126/stke.2001.111.re19

    CAS  Google Scholar 

  24. Hirschler-Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, Chen SJ, Cheung JY, Miller BA (2011) The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem 286(35):30636–30646. doi:10.1074/jbc.M111.238360

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Hoenderop JG, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJ (2003) Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J 22(4):776–785. doi:10.1093/emboj/cdg080

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397(6716):259–263. doi:10.1038/16711

    Article  CAS  PubMed  Google Scholar 

  27. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A 99(11):7461–7466. doi:10.1073/pnas.102596199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF (2006) STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol 8(9):1003–1010. doi:10.1038/ncb1454

    Article  CAS  PubMed  Google Scholar 

  29. Jahnel R, Dreger M, Gillen C, Bender O, Kurreck J, Hucho F (2001) Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line. Eur J Biochem/FEBS 268(21):5489–5496

    Article  CAS  Google Scholar 

  30. Jeon JP, Hong C, Park EJ, Jeon JH, Cho NH, Kim IG, Choe H, Muallem S, Kim HJ, So I (2012) Selective Galphai subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels. J Biol Chem 287(21):17029–17039. doi:10.1074/jbc.M111.326553

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Jin X, Touhey J, Gaudet R (2006) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem 281(35):25006–25010. doi:10.1074/jbc.C600153200

    Article  CAS  PubMed  Google Scholar 

  32. Jung S, Muhle A, Schaefer M, Strotmann R, Schultz G, Plant TD (2003) Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem 278(6):3562–3571. doi:10.1074/jbc.M211484200

    Article  CAS  PubMed  Google Scholar 

  33. Jungnickel MK, Marrero H, Birnbaumer L, Lemos JR, Florman HM (2001) Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol 3(5):499–502. doi:10.1038/35074570

    Article  CAS  PubMed  Google Scholar 

  34. Kamouchi M, Philipp S, Flockerzi V, Wissenbach U, Mamin A, Raeymaekers L, Eggermont J, Droogmans G, Nilius B (1999) Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells. J Physiol 518(Pt 2):345–358

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM (2001) Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem 276(30):28613–28619. doi:10.1074/jbc.M103272200

    Article  CAS  PubMed  Google Scholar 

  36. Kerstein PC, Jacques-Fricke BT, Rengifo J, Mogen BJ, Williams JC, Gottlieb PA, Sachs F, Gomez TM (2013) Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci: Off J Soc Neurosci 33(1):273–285. doi:10.1523/JNEUROSCI.2142-12.2013

    Article  CAS  Google Scholar 

  37. Kim H, Kim J, Jeon JP, Myeong J, Wie J, Hong C, Kim HJ, Jeon JH, So I (2012) The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels. Channels 6(5):333–343. doi:10.4161/chan.21198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S (1998) Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature 396(6710):478–482. doi:10.1038/24890

    Article  CAS  PubMed  Google Scholar 

  39. Kiselyov KI, Shin DM, Wang Y, Pessah IN, Allen PD, Muallem S (2000) Gating of store-operated channels by conformational coupling to ryanodine receptors. Mol Cell 6(2):421–431

    Article  CAS  PubMed  Google Scholar 

  40. Latorre R, Zaelzer C, Brauchi S (2009) Structure-functional intimacies of transient receptor potential channels. Q Rev Biophys 42(3):201–246. doi:10.1017/S0033583509990072

    Article  CAS  PubMed  Google Scholar 

  41. Lee KP, Choi S, Hong JH, Ahuja M, Graham S, Ma R, So I, Shin DM, Muallem S, Yuan JP (2014) Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1). J Biol Chem 289(10):6372–6382. doi:10.1074/jbc.M113.546556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Lepage PK, Boulay G (2007) Molecular determinants of TRP channel assembly. Biochem Soc Trans 35(Pt 1):81–83. doi:10.1042/BST0350081

    Article  CAS  PubMed  Google Scholar 

  43. Lepage PK, Lussier MP, Barajas-Martinez H, Bousquet SM, Blanchard AP, Francoeur N, Dumaine R, Boulay G (2006) Identification of two domains involved in the assembly of transient receptor potential canonical channels. J Biol Chem 281(41):30356–30364. doi:10.1074/jbc.M603930200

    Article  CAS  PubMed  Google Scholar 

  44. Lepage PK, Lussier MP, McDuff FO, Lavigne P, Boulay G (2009) The self-association of two N-terminal interaction domains plays an important role in the tetramerization of TRPC4. Cell Calcium 45(3):251–259. doi:10.1016/j.ceca.2008.11.002

    Article  CAS  PubMed  Google Scholar 

  45. Li M, Yu Y, Yang J (2011) Structural biology of TRP channels. Adv Exp Med Biol 704:1–23. doi:10.1007/978-94-007-0265-3_1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Liao M, Cao E, Julius D, Cheng Y (2013) Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504(7478):107–112. doi:10.1038/nature12822

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Liao Y, Erxleben C, Abramowitz J, Flockerzi V, Zhu MX, Armstrong DL, Birnbaumer L (2008) Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci U S A 105(8):2895–2900. doi:10.1073/pnas.0712288105

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong DL, Birnbaumer L (2007) Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci U S A 104(11):4682–4687. doi:10.1073/pnas.0611692104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Liao Y, Plummer NW, George MD, Abramowitz J, Zhu MX, Birnbaumer L (2009) A role for orai in TRPC-mediated Ca2+ entry suggests that a TRPC:orai complex may mediate store and receptor operated Ca2+ entry. Proc Natl Acad Sci U S A 106(9):3202–3206. doi:10.1073/pnas.0813346106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Liman ER, Corey DP, Dulac C (1999) TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci U S A 96(10):5791–5796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Lintschinger B, Balzer-Geldsetzer M, Baskaran T, Graier WF, Romanin C, Zhu MX, Groschner K (2000) Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J Biol Chem 275(36):27799–27805. doi:10.1074/jbc.M002705200

    CAS  PubMed  Google Scholar 

  52. Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54(6):905–918. doi:10.1016/j.neuron.2007.05.027

    Article  CAS  PubMed  Google Scholar 

  53. Liu X, Singh BB, Ambudkar IS (2003) TRPC1 is required for functional store-operated Ca2+ channels. Role of acidic amino acid residues in the S5-S6 region. J Biol Chem 278(13):11337–11343. doi:10.1074/jbc.M213271200

    Article  CAS  PubMed  Google Scholar 

  54. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40(3):551–561

    Article  CAS  PubMed  Google Scholar 

  55. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G (2005) MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem 280(19):19393–19400. doi:10.1074/jbc.M500391200

    Article  CAS  PubMed  Google Scholar 

  56. Lussier MP, Lepage PK, Bousquet SM, Boulay G (2008) RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Cell Calcium 43(5):432–443. doi:10.1016/j.ceca.2007.07.009

    Article  CAS  PubMed  Google Scholar 

  57. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 7(2):179–185. doi:10.1038/ncb1218

    Article  CAS  PubMed  Google Scholar 

  58. Mei ZZ, Mao HJ, Jiang LH (2006) Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Am J Physiol Cell Physiol 291(5):C1022–C1028. doi:10.1152/ajpcell.00606.2005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Mery L, Strauss B, Dufour JF, Krause KH, Hoth M (2002) The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. J Cell Sci 115(Pt 17):3497–3508

    CAS  PubMed  Google Scholar 

  60. Minke B, Parnas M (2006) Insights on TRP channels from in vivo studies in Drosophila. Annu Rev Physiol 68:649–684. doi:10.1146/annurev.physiol.68.040204.100939

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Mio K, Ogura T, Kiyonaka S, Hiroaki Y, Tanimura Y, Fujiyoshi Y, Mori Y, Sato C (2007) The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol 367(2):373–383. doi:10.1016/j.jmb.2006.12.043

    Article  CAS  PubMed  Google Scholar 

  62. Montell C (2001) Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE: Sig Transduct Knowl Environ 2001(90):re1. doi:10.1126/stke.2001.90.re1

    CAS  Google Scholar 

  63. Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY (2004) The ankyrin repeat as molecular architecture for protein recognition. Protein Sci: Publ Protein Soc 13(6):1435–1448. doi:10.1110/ps.03554604

    Article  CAS  Google Scholar 

  64. Nooren IM, Kaptein R, Sauer RT, Boelens R (1999) The tetramerization domain of the Mnt repressor consists of two right-handed coiled coils. Nat Struct Biol 6(8):755–759. doi:10.1038/11531

    Article  CAS  PubMed  Google Scholar 

  65. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274(39):27359–27370

    Article  CAS  PubMed  Google Scholar 

  66. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, Mori Y (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273(17):10279–10287

    Article  CAS  PubMed  Google Scholar 

  67. Owsianik G, Talavera K, Voets T, Nilius B (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68:685–717. doi:10.1146/annurev.physiol.68.040204.101406

    Article  CAS  PubMed  Google Scholar 

  68. Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (2015) Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature 525(7570):552. doi:10.1038/nature14871

    Article  CAS  PubMed  Google Scholar 

  69. Philipp S, Cavalie A, Freichel M, Wissenbach U, Zimmer S, Trost C, Marquart A, Murakami M, Flockerzi V (1996) A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J 15(22):6166–6171

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Putney JW Jr (2007) Multiple mechanisms of TRPC activation. In: Liedtke WB, Heller S (eds) TRP ion channel function in sensory transduction and cellular signaling cascades, Frontiers in neuroscience. CRC Press/Taylor & Francis, Boca Raton

    Google Scholar 

  71. Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN (2012) TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol 2(5):120068. doi:10.1098/rsob.120068

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  72. Raghu P, Colley NJ, Webel R, James T, Hasan G, Danin M, Selinger Z, Hardie RC (2000) Normal phototransduction in Drosophila photoreceptors lacking an InsP(3) receptor gene. Mol Cell Neurosci 15(5):429–445. doi:10.1006/mcne.2000.0846

    Article  CAS  PubMed  Google Scholar 

  73. Ramsey IS, Delling M, Clapham DE (2006) An introduction to TRP channels. Annu Rev Physiol 68:619–647. doi:10.1146/annurev.physiol.68.040204.100431

    Article  CAS  PubMed  Google Scholar 

  74. Ramsey IS, Moran MM, Chong JA, Clapham DE (2006) A voltage-gated proton-selective channel lacking the pore domain. Nature 440(7088):1213–1216. doi:10.1038/nature04700

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Rohacs T, Lopes CM, Michailidis I, Logothetis DE (2005) PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 8(5):626–634. doi:10.1038/nn1451

    Article  CAS  PubMed  Google Scholar 

  76. Saimi Y, Kung C (2002) Calmodulin as an ion channel subunit. Annu Rev Physiol 64:289–311. doi:10.1146/annurev.physiol.64.100301.111649

    Article  CAS  PubMed  Google Scholar 

  77. Schaefer M (2005) Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch - Eur J Physiol 451(1):35–42. doi:10.1007/s00424-005-1467-6

    Article  CAS  Google Scholar 

  78. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, Schultz G (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275(23):17517–17526

    Article  CAS  PubMed  Google Scholar 

  79. Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C (2008) The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels. Cell Calcium 43(3):260–269. doi:10.1016/j.ceca.2007.05.015

    Article  CAS  PubMed  Google Scholar 

  80. Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C (2012) Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx. J Biol Chem 287(42):35612–35620. doi:10.1074/jbc.M112.400952

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Schindl R, Romanin C (2007) Assembly domains in TRP channels. Biochem Soc Trans 35(Pt 1):84–85. doi:10.1042/BST0350084

    Article  CAS  PubMed  Google Scholar 

  82. Song X, Zhao Y, Narcisse L, Duffy H, Kress Y, Lee S, Brosnan CF (2005) Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture. Glia 49(3):418–429. doi:10.1002/glia.20128

    Article  PubMed  Google Scholar 

  83. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2003) Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 278(40):39014–39019. doi:10.1074/jbc.M306705200

    Article  PubMed  Google Scholar 

  84. Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y (2008) TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 121(Pt 14):2301–2307. doi:10.1242/jcs.026906

    Article  CAS  PubMed  Google Scholar 

  85. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX (2001) Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem 276(24):21303–21310. doi:10.1074/jbc.M102316200

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000) Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275(48):37559–37564. doi:10.1074/jbc.M006635200

    Article  CAS  PubMed  Google Scholar 

  87. Tsuruda PR, Julius D, Minor DL Jr (2006) Coiled coils direct assembly of a cold-activated TRP channel. Neuron 51(2):201–212. doi:10.1016/j.neuron.2006.06.023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Vannier B, Peyton M, Boulay G, Brown D, Qin N, Jiang M, Zhu X, Birnbaumer L (1999) Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc Natl Acad Sci U S A 96(5):2060–2064

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Venkatachalam K, Ma HT, Ford DL, Gill DL (2001) Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells. J Biol Chem 276(36):33980–33985. doi:10.1074/jbc.C100321200

    Article  CAS  PubMed  Google Scholar 

  90. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387–417. doi:10.1146/annurev.biochem.75.103004.142819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Venkatachalam K, Zheng F, Gill DL (2003) Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 278(31):29031–29040. doi:10.1074/jbc.M302751200

    Article  CAS  PubMed  Google Scholar 

  92. Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP (2006) CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312(5777):1220–1223. doi:10.1126/science.1127883

    Article  CAS  PubMed  Google Scholar 

  93. Villereal ML (2006) Mechanism and functional significance of TRPC channel multimerization. Semin Cell Dev Biol 17(6):618–629. doi:10.1016/j.semcdb.2006.10.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Voets T, Nilius B (2003) The pore of TRP channels: trivial or neglected? Cell Calcium 33(5-6):299–302

    Article  CAS  PubMed  Google Scholar 

  95. Wang J, Lu R, Yang J, Li H, He Z, Jing N, Wang X, Wang Y (2015) TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production. Nat Commun 6:8876. doi:10.1038/ncomms9876

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Woo JS, Lee KJ, Huang M, Cho CH, Lee EH (2014) Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca2+ levels in skeletal muscle. Biochem Biophys Res Commun 446(2):454–459. doi:10.1016/j.bbrc.2014.02.127

    Article  CAS  PubMed  Google Scholar 

  97. Xu XZ, Li HS, Guggino WB, Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89(7):1155–1164

    Article  CAS  PubMed  Google Scholar 

  98. Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S (2007) STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol 9(6):636–645. doi:10.1038/ncb1590

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Yuasa K, Matsuda T, Tsuji A (2011) Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. Cell Signal 23(7):1179–1187. doi:10.1016/j.cellsig.2011.03.005

    Article  CAS  PubMed  Google Scholar 

  100. Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, Worley PF, Muallem S (2008) STIM1 gates TRPC channels, but not orai1, by electrostatic interaction. Mol Cell 32(3):439–448. doi:10.1016/j.molcel.2008.09.020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD (2005) STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 437(7060):902–905. doi:10.1038/nature04147

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Gopfert MC, Jan LY, Jan YN (2015) Ankyrin repeats convey force to gate the NOMPC mechanotransduction channel. Cell 162(6):1391–1403. doi:10.1016/j.cell.2015.08.024

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85(5):661–671

    Article  CAS  PubMed  Google Scholar 

  104. Zitt C, Obukhov AG, Strubing C, Zobel A, Kalkbrenner F, Luckhoff A, Schultz G (1997) Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol 138(6):1333–1341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Luckhoff A, Schultz G (1996) Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron 16(6):1189–1196

    Article  CAS  PubMed  Google Scholar 

  106. Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY (2016) Cryo-electron microscopy structure of the TRPV2 ion channel. Nat Struct Mol Biol 23(2):180–186. doi:10.1038/nsmb.3159

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of California, San Francisco, CA, USA

    Shengjie Feng

Authors
  1. Shengjie Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shengjie Feng .

Editor information

Editors and Affiliations

  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Feng, S. (2017). TRPC Channel Structure and Properties. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_2

Download citation

Publish with us

Policies and ethics

Search

Navigation