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Immunoliposome-Mediated Delivery of Chemotherapeutics

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From Clone to Clinic

Part of the book series: Developments in Biotherapy ((DIBI,volume 1))

Abstract

One of the tools presently under investigation to achieve site specific drug delivery is the combination of drug-containing liposomes and antibodies (so-called immunoliposomes). The potentials and limitations of this form of targeted chemotherapy are discussed, followed by an example of the use of drug-loaded immunoliposomes in the intracavitary therapy of ovarian carcinoma.

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References

  • Allen, T.M., Hansen, C. and Rutledge, J. (1989). Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta 981: 27–35.

    CAS  Google Scholar 

  • Aragnol, D. and Leserman, L.D. (1986). Immune clearance of liposomes inhibited by an anti-Fc receptor antibody in vivo. Proc. Natl. Acad. Sci. USA 83: 2699–2703.

    Article  PubMed  CAS  Google Scholar 

  • Bast Jr., R.C. and Knapp, R.C. (1987). The emerging role of monoclonal antibodies in the clinical management of epithelial ovarian carcinoma. Important Adv. Oncol. 39–53.

    Google Scholar 

  • Blok, M.C., van der Neut-Kok, E.C.M., van Deenen, L.L.M. and de Gier, J. (1975). The effect of chain length and liquid phase transition on the selective permeability of liposomes. Biochim. Biophys. Acta 406: 187–196.

    CAS  Google Scholar 

  • Bodor, N. and Brewster, M.E. (1986). Problems of delivery of drugs to the brain. In: Methods of Drug Delivery. (G.M. Ihler, ed.), Pergamon Press, Oxford, pp. 153–202.

    Google Scholar 

  • Boerman, O., Makldnk, W., Massuger, L., Thomas, C., Kenemans, P., Hanselaar, T. and Poels, L. (1989). Monoclonal antibodies against ovarian carcinoma-associated antigens, raised by immunization with cyst fluid. Anticancer Res. 9: 551–558.

    PubMed  CAS  Google Scholar 

  • Collins, D. and Huang, L. (1987). Cytotoxicity of diphtheria toxin A fragment to toxin-resistant murine cells delivered by pH-sensitive immunoliposomes. Cancer Res. 47: 735–739.

    PubMed  CAS  Google Scholar 

  • Connor, J., Yatvin, M.B. and Huang, L. (1984). pH-sensitive liposomes: Acid-induced liposome fusion. Proc. Natl. Acad. Sci. USA 81: 1715–1718.

    Article  PubMed  CAS  Google Scholar 

  • Connor J., Sullivan, S. and Huang, L. (1985). Monoclonal antibody and liposomes. Pharmacol. Ther. 28: 341–365.

    Article  PubMed  CAS  Google Scholar 

  • Durrant, L.G., Robins, R.A., Armitage, N.C., Brown, A., Baldwin, R.W. and Hardcastle, J.D. (1986). Association of antigen expression and DNA ploidy in human colorectal tumors. Cancer Res. 46: 3542–3549.

    Google Scholar 

  • Forssen, E.A. and TökĂ©s, Z.A. (1983). Attenuation of dermal toxicity of doxorubicin by liposome encapsulation. Cancer Treat. Rep. 67: 481–484.

    CAS  Google Scholar 

  • Gabizon, A. and Papahadjopoulos, D. (1988). Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA 85: 6949–6953.

    Article  PubMed  CAS  Google Scholar 

  • Gitman, A.G. and Loyter, A. (1984). Construction of fusogenic vesicles bearing specific monoclonal antibodies. J. Biol. Chem. 259: 9813–9820.

    PubMed  CAS  Google Scholar 

  • Greiner, J.W., Horan Hand, P., Colcher, D., Weeks, M., Thor, A., Noguchi, P., Petska, S. and Schlom, J. (1987). Modulation of human tumour antigen expression. J. Lab. Clin. Med. 109: 244261.

    Google Scholar 

  • Hakomori, S. and Kannagi, R. (1983). Glycosphingolipids as tumor-associated and differentiation markers. J. Natl. Cancer Inst. 71: 231–251.

    PubMed  CAS  Google Scholar 

  • Heath, T.D. (1988). Liposome dependent drugs. In: Liposomes as Drug Carriers. Recent Trends and Progress. G. Gregoriadis (Ed.), John Wiley & Sons, Chichester, pp. 709–718.

    Google Scholar 

  • Heath, T.D., Fraley, R.T., Bentz, J., Voss Jr., E.W., Herron, J.N. and Papahadjopoulos, D. (1984). Antibody-directed liposomes. Determination of affinity constants for soluble and liposome-bound antifluorescein. Biochim. Biophys. Acta 770: 148–158.

    CAS  Google Scholar 

  • Ho, R.J.Y., Rouse, B.T. and Huang, L. (1986). Target-sensitive immunoliposomes: preparation and characterization. Biochemistry 25: 5500–5506.

    Article  PubMed  CAS  Google Scholar 

  • Kirby, C.J., Clarke, J. and Gregoriadis, G. (1980). Cholesterol content of small unilamellar liposomes controls phospholipid loss to high density lipoproteins in the presence of serum. FEBS Lett. 111: 324–328.

    Article  PubMed  CAS  Google Scholar 

  • Markman, M. (1986). Intraperitoneal antineoplastic agents for tumors principally confined to the peritoneal cavity. Cancer Treat. Rep. 13: 219–242.

    Article  CAS  Google Scholar 

  • Martin, F.J. and Papahadjopoulos, D. (1982). Irreversible coupling of immunoglobulin fragments to preformed vesicles. J. Biol. Chem. 257: 286–288.

    PubMed  CAS  Google Scholar 

  • Moseley, K.R., Battaile, A., Knapp, R.C. and Haisma, HJ. (1988). Localization of radiolabelled F(ab’)2 fragments of monoclonal antibodies in nude mice bearing intraperitoneally growing human ovarian cancer xenografts. Int. J. Cancer 42: 368–372.

    Article  PubMed  CAS  Google Scholar 

  • Nässander, U.K., Storm, G., Peeters, P.A.M. and Crommelin, D.J.A. (1990). Liposomes. In: Biodegradable Polymers as Drug Delivery Systems. (Langer, R. and Chasin, M. eds.), Marcel Dekker, Inc., in press.

    Google Scholar 

  • Nayar, R., Fidler, I.J. and Schroit, A.J. (1988). Potential application of pH-sensitive liposomes as drug delivery systems. In: Liposomes as Drug Carriers. (G. Gregoriadis, ed.), John Wiley and Sons Ltd, pp. 771–782.

    Google Scholar 

  • Ohkuma, S. and Poole, B. (1978). Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. USA 75:3327–3331

    Article  PubMed  CAS  Google Scholar 

  • Peeters, P.A.M., Storm, G. and Crommelin, D.J.A. (1987). Immunoliposomes in vivo: state of the art. Adv. Drug Del. Rev. 1: 249–266.

    Google Scholar 

  • Poels, L.G., Peters, D., van Megen, Y., Vooijs, G.P., Verheyen, R.N.M., Willemen, A., van Niekerk, C.C., Jap, P.H.K., Mungyer, G. and Kenemans, P. (1986). Monoclonal antibody against human ovarian tumor-associated antigens. J. Natl. Cancer Inst. 76: 781–791.

    PubMed  CAS  Google Scholar 

  • Poste, G., Bucane, C., Raz, A., Bugelski, P., Kirsh, R. and Fidler, I.J. (1982). Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res. 42: 1412–1422.

    PubMed  CAS  Google Scholar 

  • Poste, G. (1983). Liposome targeting in vivo: problems and opportunities. Biol. Cell. 47: 19–38.

    CAS  Google Scholar 

  • Scatchard, G. (1949). The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51: 660–672.

    Article  CAS  Google Scholar 

  • Scherphof, G.L., Roerdink, F., Dijkstra, J., Ellens, H., Zanger de, R. and Wisse, E. (1983). Uptake of liposomes by rat and mouse hepatocytes and Kupffer cells. Biol. Cell. 47: 47–58.

    Google Scholar 

  • Scherphof, G.L. (1986). Liposomes in biology and medicine. In: Lipids and Membranes: Past, Present and Future. (J.A.F. Op den Kamp, B. Roelofsen and K.W.A. Wirtz, eds.), Elsevier, Amsterdam, pp. 113–136.

    Google Scholar 

  • Senior, J.H. (1987). Fate and behavior of liposomes in vivo: A review of controlling factors. CRC Critical Reviews in Therapeutic Drug Carrier Systems 3: 123–193.

    PubMed  CAS  Google Scholar 

  • Storm, G., Oussoren, C. and Peeters, P.A.M. (1990). Safety of liposome administration. In: Membrane Lipid Oxidation. Vol. 3 (C. Vigo-Pelfrey, ed.), C.R.C. Press, Boca Raton, Florida. In press.

    Google Scholar 

  • Sullivan, S.M., Connor, J. and Huang, L. (1986). Immunoliposomes: Preparation, properties, and applications. Med. Res. Rev. 6: 171–195.

    CAS  Google Scholar 

  • Tagliabue, E., Menard, S., Della Torre, G., Barbanti, P., Mariani-Costantini, R., Porro, G. and Colnaghi, M.I. (1985). Generation of monoclonal antibodies reacting with human epithelial ovarian cancer. Cancer Res., 45: 379–385.

    PubMed  CAS  Google Scholar 

  • Thigpen, J.T., Vance, R.B. and Lambuth, B.W. (1988). Ovarian carcinoma: the role of chemotherapy. Sem. Oncol. 15: 16–23.

    CAS  Google Scholar 

  • Toonen, P.A.H.M. and Crommelin, D.J.A. (1983). Immunoglobulins as targeting agents for liposome-encapsulated drugs. Pharm. Weekbl. Sci. Ed. 5: 269–280.

    Article  CAS  Google Scholar 

  • Torchilin, V.P. (1985). Liposomes as targetable drug carriers. CRC Critical Reviews in Therapeutic Drug Carrier Systems 2: 65–115.

    PubMed  CAS  Google Scholar 

  • Tycko, B. and Maxfield, F.R. (1982). Rapid acidification of endocytic vesicles containing a macroglobulin. Cell 28: 643–648.

    Article  PubMed  CAS  Google Scholar 

  • Wright, S. and Huang, L. (1989). Antibody-directed liposomes as drug-delivery vehicles. Adv. Drug Del. Rev. 3: 343–389.

    Google Scholar 

  • Yatvin, M.B., Weinstein, J.N., Dennis, W.H. and Blumenthal, R. (1978). Design of liposomes for enhanced local release of drugs by hyperthermia. Science 202:1290–1293.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. U. K. Nässander
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  2. G. Storm
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  3. P. A. Steerenberg
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  4. W. H. De Jong
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  5. G. de Groot
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  6. L. G. Poels
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  7. Q. G. C. M. van Hoesel
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  8. D. J. A. Crommelin
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Editor information

Editors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutics, University of Utrecht, Croesestraat 79, Utrecht, 3522 AD, The Netherlands

    D. J. A. Crommelin (Professor of Pharmacology) (Professor of Pharmacology)

  2. TNO Primate Center, Rijswijk, P.O.Box 5815, 2280 HV, The Netherlands

    H. Schellekens (Senior Research Fellow) (Senior Research Fellow)

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© 1990 Springer Science+Business Media Dordrecht

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Nässander, U.K. et al. (1990). Immunoliposome-Mediated Delivery of Chemotherapeutics. In: Crommelin, D.J.A., Schellekens, H. (eds) From Clone to Clinic. Developments in Biotherapy, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3780-5_44

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  • DOI: https://doi.org/10.1007/978-94-011-3780-5_44

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5683-0

  • Online ISBN: 978-94-011-3780-5

  • eBook Packages: Springer Book Archive

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